Production of sFas, sFasL, TRAIL by placental tissue during normal pregnancies and those complicated by gestosis



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Abstract

Surface molecules secretory variants can appear in different biological liquids because of various physiological and pathological processes. The aim of this investigation was comparison of sFas, sFasL, TRAIL serum concentrations and their placental production for different development terms in normal pregnancies and those complicated by gestosis. We observed that sFas concentrations in collected after placental tissue incubation supernatants in 3th trimester placentas and 1th trimester one were equal. Secretion of sFasL was decreased and secretion ofTRAIL was increased in terminal gestation age in comparison with early pregnancy. sFas placental tissue secretion was increased and sFasL secretion was lightly increased in complicated by gestosis pregnancies in comparison with normal one. TRAIL placental tissue secretion was equal in normal pregnancies and those complicated by gestosis. Serum sFas and sFasL were detected in neither normal pregnancies group, nor in those complicated by gestosis. Variation of sFas, sFasL and TRAIL placental tissue secretion during normal placental development reflects placental structures formation and stabilization. Compensatory protection mechanisms against abundant angiogenic and apoptotic stimulus and maternal lymphocytes cytotoxic affects are initiated in placental tissue during gestosis.

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Copyright (c) 2010 Stepanova O.I., Lesnichija M.V., Klukina M.A., Arzhanova O.N., Selkov S.A., Sokolov D.I.

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