Regulation of the blood circulation by selective inhibitors of nitric oxide synthesis in experimental haemorrhagic shock



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Abstract

The results in volume-controlled haemorrhagic shock in rats demonstrated that selective inhibitors of nitric oxide synthases (derivates of the lysine, ornithine, guanidine, S-methylisothiourea) considerably enhanced the efficiency of infusion therapy. All these selective inhibitors induced improvement of cardiac work (increased stroke volume, cardiac output, left ventrical work). The more visible effect was revealed using N-5-(iminoethyl)-L-ornithine and aminoguanidine.These agents have demonstrated the most pronounced correction of the cardiovascular system indexes and 100% survival of animals.

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