The enzymes of the purine metabolism in the differentiation of gout arthritis and osteoarthrosis



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The activity of Adenosin Deaminase (ADA), Adenosin Monophosphate Deaminase (AMPDA), Adenin Deaminase (AD), Guanin Deaminase (GDA), Guanosin Deaminase (GSDA), Guanosin phosphorylase (GP) and Purin Nucleosid Phosphorylase (PNP) were studies in lysates of erythrocytes, lymphocytes and plasma of the blood of 52 patients with osteoarthrosis (OA), 32 patients with gout arthritis (GA) and 30 healthy people. While analyzing the enzyme indices in the lysates of erythrocytes, lymphocytes and in plasma of the blood of healthy people we didn't find out their dependence on the age and sex. The change of the activity of the enzymes depended on the clinical peculiarities of the diseases and were most of all vivid at the development of synovitis in the patients with OA and with the cronical stage of GA.The results of the comparative studies of the activity of the enzymes of Purine metabolism in the three biological media revealed the essential enzyme differences in the blood of the patients with OA and GA.The indices of the activity of AD in plasma, GDA in the erythrocytes and GP in the lymphocytes were the most evident in the differentiation of OA and GA.They are recommended to use in the clinical practice.

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References

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Copyright (c) 2010 Zborovsky A.B., Bedina S.A., Martemjanov V.F., Mozgovaya E.E., Kukushcina E.V., Stazharov M.Y., Gerusov Y.I., Evdocimova E.V.

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