Clinical and electrophysiological heterogeneity of essential tremor

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Abstract

This study aimed to identify clinical and electrophysiological signs that determine the phenotypic heterogeneity of essential tremor using a cluster analysis. Seventy-five patients with essential tremor were examined. To identify the heterogeneity of the disease, a cluster analysis was applied (k-means method). Clustering was performed according to clinical and electromyographic parameters. The heterogeneity of essential tremor is justified by amplitude characteristics, topography of tremor, duration disease, and severity of impaired of daily activity. Detecting heterogeneity in essential tremor can broaden understanding of pathogenesis disease and justify heterogeneity of the pharmacological response in patients with essential tremor.

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About the authors

Zamira M. Muruzheva

Institute of Experimental Medicine

Author for correspondence.
Email: zamira.muruzheva@mail.ru

Research Worker, Pavlov Department of Physiology

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Aleksey A. Ezhov

Peter the Great Saint Petersburg Polytechnic University

Email: a.a.ezhow@gmail.com

student of the Department of Biophysics

Russian Federation, 29, Polytechnitcheskaya street, St.-Petersburg, 195251

Marina N. Karpenko

Institute of Experimental Medicine; Peter the Great Saint Petersburg Polytechnic University

Email: mnkarpenko@mail.ru

PhD in Biology, Associate Professor, Senior research scientist, Pavlov Department of Physiology; Associate Professor of the Department of Biophysics

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376; 29, Polytechnitcheskaya street, St.-Petersburg, 195251

Marina A. Fominceva

Institute of Experimental Medicine

Email: marina.fominceva@inbox.ru

Functional diagnostics specialist

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Victor M. Klimenko

Institute of Experimental Medicine

Email: klimenko_victor@mail.ru

MD, PhD, Professor, Head of the Pavlov Department of Physiology

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Igor D. Stolyarov

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences

Email: sid@ihb.spb.ru

MD, PhD, Professor, Head of the Laboratory of Neuroimmunology

Russian Federation, 197376, Saint-Petersburg, Ac. Pavlova street, 9

References

  1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25(5):534-541. https://doi.org/10.1002/mds.22838.
  2. Benito-Leon J, Bermejo-Pareja F, Morales JM, et al. Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord. 2003;18(4):389-394. https://doi.org/10.1002/mds.10376.
  3. Louis ED, Ottman R. How familial is familial tremor? The genetic epidemiology of essential tremor. Neurology. 1996;46(5):1200-1205. https://doi.org/10.1212/WNL.46.5.1200.
  4. Benito-Leon J, Bermejo-Pareja F, Louis ED, Neurological Disorders in Central Spain Study G. Incidence of essential tremor in three elderly populations of central Spain. Neurology. 2005;64(10):1721-1725. https://doi.org/10.1212/01.WNL.0000161852.70374.01.
  5. Муружева З.М., Карпенко М.Н., Клименко В.М. Гетерогенность фармакологического ответа как основа выделения подтипов эссенциального тремора // Обзоры по клинической фармакологии и лекарственной терапии. - 2018. - Т. 16. - № 1. - С. 54-59. [Muruzheva ZM, Karpenko MN, Klimenko VM. The heterogeneity of drug response as the basis of identification of essential tremor subtypes. Obzory po klinicheskoi farmakologii i lekarstvennoi terapii. 2018;16(1):54-59. (In Russ.)]
  6. Захаров Д.В., Ярыгина Ю.В., Михайлов В.А., и др. Исследование эффективности лечения эссенциального тремора с использованием треморографии // Альманах клинической медицины. - 2016. - Т. 44. - № 3. - С. 336-344. [Zakharov DV, Yarygina YV, Mikhaylov VA, et al. A study of efficacy of treatment for essential tremor using tremorography. Almanac of clinical medicine. 2016;44(3):336-344. (In Russ.)]
  7. Deuschl G, Lucking CH, Schenck E. Essential tremor: electrophysiological and pharmacological evidence for a subdivision. J Neurol Neurosurg Psychiatry. 1987;50(11):1435-1441. http://dx.doi.org/10.1136/jnnp.50.11.1435.
  8. Akbostanci MC, Ulkatan S, Yigit A, et al. Difference of disability between electrophysiologic subgroups of essential tremor. Can J Neurol Sci. 2000;27(1)60-64. https://doi.org/10.1017/S0317167100051994.
  9. Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord. 1998;13 Suppl 3:2-23. https://doi.org/10.1002/mds.870131303.
  10. Fahn S, Tolosa E, Marín C. Clinical rating Scale for Tremor. In: Parkinson’s Disease and Movement Disorders. Ed. by J. Jankovik, E. Tolosa. Münich: Urban & Schwarzenberg; 1988. P. 225-234.
  11. Stacy MA, Elble RJ, Ondo WG, et al. Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor. Mov Disord. 2007;22(6):833-838. https://doi.org/10.1002/mds.21412.
  12. Bain PG, Findley LJ, Atchison P, et al. Assessing tremor severity. J Neurol Neurosurg Psychiatry. 1993;56(8):868-873. http://dx.doi.org/10.1136/jnnp.56.8.868.
  13. Koster B, Deuschl G, Lauk M, et al. Essential tremor and cerebellar dysfunction: abnormal ballistic movements. J Neurol Neurosurg Psychiatry. 2002;73(4):400-405. http://dx.doi.org/10.1136/jnnp.73.4.400.
  14. Louis ED, Hernandez N, Michalec M. Prevalence and correlates of rest tremor in essential tremor: cross-sectional survey of 831 patients across four distinct cohorts. Eur J Neurol. 2015;22(6):927-932. https://doi.org/10.1111/ene.12683.
  15. Filip P, Lungu OV, Manto MU, Bares M. Linking Essential Tremor to the Cerebellum: Physiological Evidence. Cerebellum. 2016;15(6):774-780. https://doi.org/10.1007/s12311-015-0740-2.
  16. Benito-Leon J, Labiano-Fontcuberta A. Linking Essential Tremor to the Cerebellum: Clinical Evidence. Cerebellum. 2016;15(3):253-262. https://doi.org/10.1007/s12311-015-0741-1.
  17. Avanzino L, Bove M, Tacchino A, et al. Cerebellar involvement in timing accuracy of rhythmic finger movements in essential tremor. Eur J Neurosci. 2009;30(10):1971-1979. https://doi.org/10.1111/j.1460-9568.2009.06984.x.
  18. Cohen O, Pullman S, Jurewicz E, et al. Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics. Arch Neurol. 2003;60(3):405-410. https://doi.org/10.1001/archneur.60.3.405.
  19. Bermejo-Pareja F, Puertas-Martin V. Cognitive features of essential tremor: a review of the clinical aspects and possible mechanistic underpinnings. Tremor Other Hyperkinet Mov (N Y). 2012;2. https://doi.org/10.7916/D89W0D7W.
  20. Frisina PG, Tse W, Halbig TD, Libow LS. The pattern of cognitive-functional decline in elderly essential tremor patients: an exploratory-comparative study with Parkinson’s and Alzheimer’s disease patients. J Am Med Dir Assoc. 2009;10(4):238-242. https://doi.org/10.1016/j.jamda.2008.10.013.
  21. Bermejo-Pareja F. Essential tremor - a neurodegenerative disorder associated with cognitive defects? Nat Rev Neurol. 2011;7(5):273-282. https://doi.org/10.1038/nrneurol.2011.44.
  22. Louis ED, Huey ED, Gerbin M, Viner AS. Depressive traits in essential tremor: impact on disability, quality of life, and medication adherence. Eur J Neurol. 2012;19(10):1349-1354. https://doi.org/10.1111/j.1468-1331.2012.03774.x.
  23. Sengul Y, Sengul HS, Yucekaya SK, et al. Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor. Acta Neurol Belg. 2015;115(3):281-287. https://doi.org/10.1007/s13760-014-0396-6.
  24. Lee SM, Kim M, Lee HM, et al. Nonmotor symptoms in essential tremor: Comparison with Parkinson’s disease and normal control. J Neurol Sci. 2015;349(1-2):168-173. https://doi.org/10.1016/j.jns.2015.01.012.
  25. Louis ED. The Roles of Age and Aging in Essential Tremor: An Epidemiological Perspective. Neuroepidemiology. 2019;52(1-2):111-118. https://doi.org/10.1159/000492831.
  26. Louis ED. “Essential tremor” or “the essential tremors”: Is this one disease or a family of diseases? Neuroepidemiology. 2014;42(2):81-89.
  27. Huey ED, Cosentino S, Chapman S, et al. Self-report depressive symptoms are dissociated from tremor severity in essential tremor. Parkinsonism Relat Disord. 2018;50:87-93. https://doi.org/10.1016/ j.parkreldis.2018.02.031.
  28. Calzetti S, Baratti M, Gresty M, Findley L. Frequency/amplitude characteristics of postural tremor of the hands in a population of patients with bilateral essential tremor: implications for the classification and mechanism of essential tremor. J Neurol Neurosurg Psychiatry. 1987;50(5):561-567. http://dx.doi.org/10.1136/jnnp.50.5.561.
  29. Koguchi Y, Nakajima M, Kawamura M, Hirayama K. Clinical subtypes of essential tremor and their electrophysiological and pharmacological differences. Rinsho Shinkeigaku. 1995;35(2):132-136.
  30. Ярыгина Ю.В., Захаров Д.В., Михайлов В.А., и др. Исследование клинического полиморфизма и качества жизни больных эссенциальным тремором // Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. - 2017. - Т. 2. - С. 71-78. [Yarygina YV, Zakharov DV, Mikhaylov VA, et al. Study of clinical polymorphism and the quality of life of patients with essential tremor. Obozreniye psikhiatrii i meditsinskoy psikhologii imeni VM Bekhtereva. 2017;(2):71-78. (In Russ.)]

Supplementary files

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2. Fig. 1. Redistribution of patients with essential tremor between groups with sequential allocation of 4 to 2 clusters

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Copyright (c) 2018 Muruzheva Z.M., Ezhov A.A., Karpenko M.N., Fominceva M.A., Klimenko V.M., Stolyarov I.D.

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