Clinical and electrophysiological heterogeneity of essential tremor
- Authors: Muruzheva Z.M.1, Ezhov A.A.2, Karpenko M.N.1,2, Fominceva M.A.1, Klimenko V.M.1, Stolyarov I.D.3
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Affiliations:
- Institute of Experimental Medicine
- Peter the Great Saint Petersburg Polytechnic University
- N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences
- Issue: Vol 18, No 4 (2018)
- Pages: 64-72
- Section: Clinical research
- Published: 15.12.2018
- URL: https://journals.eco-vector.com/MAJ/article/view/11687
- DOI: https://doi.org/10.17816/MAJ18464-72
- ID: 11687
Cite item
Abstract
This study aimed to identify clinical and electrophysiological signs that determine the phenotypic heterogeneity of essential tremor using a cluster analysis. Seventy-five patients with essential tremor were examined. To identify the heterogeneity of the disease, a cluster analysis was applied (k-means method). Clustering was performed according to clinical and electromyographic parameters. The heterogeneity of essential tremor is justified by amplitude characteristics, topography of tremor, duration disease, and severity of impaired of daily activity. Detecting heterogeneity in essential tremor can broaden understanding of pathogenesis disease and justify heterogeneity of the pharmacological response in patients with essential tremor.
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About the authors
Zamira M. Muruzheva
Institute of Experimental Medicine
Author for correspondence.
Email: zamira.muruzheva@mail.ru
Research Worker, Pavlov Department of Physiology
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376Aleksey A. Ezhov
Peter the Great Saint Petersburg Polytechnic University
Email: a.a.ezhow@gmail.com
student of the Department of Biophysics
Russian Federation, 29, Polytechnitcheskaya street, St.-Petersburg, 195251Marina N. Karpenko
Institute of Experimental Medicine; Peter the Great Saint Petersburg Polytechnic University
Email: mnkarpenko@mail.ru
PhD in Biology, Associate Professor, Senior research scientist, Pavlov Department of Physiology; Associate Professor of the Department of Biophysics
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376; 29, Polytechnitcheskaya street, St.-Petersburg, 195251Marina A. Fominceva
Institute of Experimental Medicine
Email: marina.fominceva@inbox.ru
Functional diagnostics specialist
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376Victor M. Klimenko
Institute of Experimental Medicine
Email: klimenko_victor@mail.ru
MD, PhD, Professor, Head of the Pavlov Department of Physiology
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376Igor D. Stolyarov
N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences
Email: sid@ihb.spb.ru
MD, PhD, Professor, Head of the Laboratory of Neuroimmunology
Russian Federation, 197376, Saint-Petersburg, Ac. Pavlova street, 9References
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