Email this article Effectiveness of cell therapy with autologous bone marrow mononuclear cells in complex treatment of patients with coronary artery disease
- Authors: Sedov V.М.1, Nemkov A.S.1, Afanasyev В.V.1, Zverev О.G.2, Belyj S.A.1, Rigkova D.V.2
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Affiliations:
- Pavlov State Medical University
- Central Research Institute of Roendgenology and Radiology
- Issue: Vol 7, No 1 (2007)
- Pages: 112-116
- Section: New technologies in diagnostics and treatment of atherosclerosis
- Published: 15.02.2007
- URL: https://journals.eco-vector.com/MAJ/article/view/692628
- ID: 692628
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Abstract
The effectiveness of intracoronary and intramyocardial delivery of autologous bone marrow stem cells (ABMSC) in patients with non-acute ischemic heart disease still remains unclear.
Methods: Autologous transplantation of bone marrow stem cells was performed in 80 patients. In 70 patients ABMSC were injected intracoronary during coronary angiography. Intramyocardial delivery was used in 8 patients as adjunctive therapy to coronary artery bypass grafting (CABG), and in 2 patients - intracoronary during angioplasty.
Results: Patients were followed for 3-24 months. We observed clinical improvement in 63 patients. A significant reduction in the number of angina episodes and nitroglycerin consumption was noted. Single-photon emission computer tomography (SPECT) study revealed significant improvements in the previously non- or hypoperfused myocardium. Positron emission tomography scanning demonstrated improvement in myocardial viability. Echocardiography revealed dimension of end-diastolic and end-systolic volume of left ventricle (LV) and augmentation of global LV ejection fraction in patients with previously dilated LV. Five patients died. 2 patients had only clinical improvement without changing in SPECT study.
Conclusions: autologous bone marrow cell therapy is a feasible, safe and useful approach for the restoration of damaged myocardium as adjunctive therapy to CABG, coronary angioplasty or medical treatment for human ischemic heart disease.
Keywords
About the authors
V. М. Sedov
Pavlov State Medical University
Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg
A. S. Nemkov
Pavlov State Medical University
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg
В. V. Afanasyev
Pavlov State Medical University
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg
О. G. Zverev
Central Research Institute of Roendgenology and Radiology
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg
S. A. Belyj
Pavlov State Medical University
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg
D. V. Rigkova
Central Research Institute of Roendgenology and Radiology
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).