Peculiarities of anemic syndrom in patients with rheumatoid arthritis and system lupus erythematosus

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Abstract

Hematological abnormalitis develop quite often it the patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Anaemia is the most frequent hematological syndrome. The anaemia was diagnosed in 49,1% RA cases and 48,8% hard SLE. The essential pathogenetic differences were revealed between an iron deficiency anaemia and anaemia in a chronic disease, prevailing at the patients RA and SLE. The anaemia at RA and SLE was characterized by normal or low level of iron, low percent iron transferrin saturation at high levels of a serum transferrin, gaptoglobin and ferritin reduced production of erythrocytes in an bone marrow at presence of adequate iron reserves, and also essential elevation of serum erythropoietin. Thus erythropoietin level mostly depended on the activity of a main disease, than from of an expression of an anaemia symptoms.

About the authors

V. I. Mazurov

Medical Academy of Postgraduate Studies

Author for correspondence.
Email: shabanov@mail.rcom.ru

Член-корреспондент РАМН

Russian Federation, St. Petersburg

A. M. Lila

Medical Academy of Postgraduate Studies

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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