The role of sensitization in migraine

Abstract


The review provides recent knowledge on the contribution of peripheral and central sensitization to neurobiology of migraine. Mechanism underling development of sensitization, methods of induction and study of the phenomenon are described. A correlations between neurophysiological consequences of sensitization occurred in various anatomic structures and clinical manifestations of the disease are set up.

A Y Sokolov

Valdman Institute of Pharmacology, St. Petersburg Pavlov State Medical University, St. Petersburg

Email: leshasokolov1@rambler.ru

O A Lyubashina

Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

Y D Ignatov

Valdman Institute of Pharmacology, St. Petersburg Pavlov State Medical University, St. Petersburg

A V Amelin

Valdman Institute of Pharmacology, St. Petersburg Pavlov State Medical University, St. Petersburg

S S Panteleev

Valdman Institute of Pharmacology, St. Petersburg Pavlov State Medical University, St. Petersburg; Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

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