Endogenous digitalis-like substances and alcohol dependence



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Endogenous digitalis-like substances (EDLS) and Na/K-ATPase are involved into water-salt homeostasis, regulation of cardiovascular system functions and pathogenesis of arterial hypertension. Na/K-ATPase activity is modified also by ethanol. Experiments conducted by authors showed the ability of EDLS, in particular, marinobufagenin, to suppress motivational-and-reinforcing properties of this psychoactive agent. "Na/K-ATPase- EDLS" system is supposed to contribute to individual vulnerability to alcohol dependence, while centrally acting selective inhibitors of Na/K-ATPase are potential medications for the treatment of alcoholism. Data are presented also demonstrating the involvement of EDLS into the pathogenesis of arterial hypertension in alcohol withdrawal and in neurotoxic properties of this agent.

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V A Kashkin

Valdman Institute of Pharmacology, Pavlov Medical University

E E Zvartau

Valdman Institute of Pharmacology, Pavlov Medical University

A Ya Bagrov

Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg

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