THE INFLUENCE OF DYSLIPIDEMIA ON PARAMETERS OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH STABLE ANGINA PECTORIS



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Abstract

Study objective: To determine the features of cellular and humoral immune responses in patients with stable angina pectoris (SA) having different degrees of coronary vascular bed impairments. Materials and methods: In a group comprising 67 SA patients aged 60,1±10,1 years, coronary angiography and clinical blood tests were performed, lipid profile was determined, and cellular and humoral immune responses were studied. Results: Increased blood lipid atherogenicity index (BLAI) is associated with increased circulatory immune complexes (CIC) at p<0,05. In IHD patients having myocardium antigen titer score (MATS) from 3 to 8, BLAI is significantly higher than in IHD patients whose MATS is 1 to 2 (p<0,05). Myocardium antigen level increases with increasing blood tryglycerides (p<0,05). Increased LDP and total cholesterol were associated with increased leucocyte migration inhibition index (LMI) (r=0,35 at р<0,05 and r=0,41 at р<0,05, respectively). Lipid profile normalization helps to decrease MATS (p<0,05) and ILMI (p<0,05). Conclusion: The data suggest that dyslipidemia adversely influences IHD by activating inflammatory responses of both types, cellular and humoral.

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About the authors

D S Shcheglov

City Mariinsky hospital

Email: dmshcheglov@mail.ru
St. Petersburg, Russia

I P Dudanov

City Mariinsky hospital

Email: ipdudanov@gmail.com
St. Petersburg, Russia

L V Shcheglova

City Mariinsky hospital; St. Petersburg State Pediatric Medical University

Email: shcheglovalar@mail.ru
St. Petersburg, Russia

M V Avdeeva

St. Petersburg State Pediatric Medical University; North-Western State Medical University named after I. I. Mechnikov

Email: Lensk69@mail.ru
St. Petersburg, Russia

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Copyright (c) 2016 Shcheglov D.S., Dudanov I.P., Shcheglova L.V., Avdeeva M.V.

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