Vol 14, No 2 (2014)

Lung cancer in 13,7-51,4% cases complicated with paracancerous changes in the thoracic cavity. Computed tomography allows to detect the true size of the tumor and final stage T (tumor) of oncological process as well in preoperative period. The accuracy of computer tomography in the evaluation of the regional spread of the tumor process is 90%. Combination of tumor and inflammation (paracancerous changes in the thoracic cavity) in the lungs is difficult to detect the true margins of the tumor by CT. Because of this combination evaluation of regional spread is incorrect. The accuracy of CT in determining the regional spread complicated by lung cancer is 77%. Patients with paracancerous changes in the thoracic cavity need to undergo MRI in preoperative period to evaluate the grade of local invasion of tumor. Post contrast T1-MRI gives the opportunity to visualize the margins of tumor, and also to differentiate it from the lymph nodes.

Short-term effects of colloidal silver taken orally (150 μg once a day for 3 days) on the function of the blood neutrophilic granulocytes have been studied in healthy volunteers (n=30). Total white blood cell (WBC) count and WBC differential count (Wright staining of the blood smears) have been analysed, as well as myeloperoxidase (MPO) activity and total lysosomal cationic proteins (LCP) level as assessed by semi-quantitative cytochemical evaluation. Total WBC and absolute neutrophil count were found to be elevated already in 2 hr after the silver intake, the values registered on the days 2 and 3 of the study being higher than those of each previous day (p<0,05). MPO activity (assessed by mean cytochemical coefficient) increases after the intake of colloidal silver. MPO values on the day 3 of the study, both before and after silver intake, are found to be higher (p<0,05) than the basal value of the day 1. Total LCP content after the silver intake does not differ (p>0,05) from basal values on each of the study days. However, the count of the neutrophils with low (1+) MPO activity or LCP content decreases (p<0,05), while the amount of those with high (3+) MPO activity or LCP content increases (p<0,05) after the intake of silver. Thus, colloidal silver, when taken orally at a small dose for a short period, can stimulate both oxygen-dependent and oxygen-independent microbicidal mechanisms of blood neutrophils. This may account for systemic beneficial effects of colloidal silver in infectious diseases.

Duration of main clinical attributes and frequency of recurrent and chronic forms occurrence during the use of wobenzym in complex therapy were analyzed in 87 patients with fixed diagnosis of Lyme disease. It was established that their duration shortened in 2,2 times (р<0,05). Accounting the data received the usage of wobenzym which potentiates the effect of antibiotics in complex therapy of Lyme disease was validated.

Tuberculosis epidemic process is characterized by decreasing in the basic epidemiological indexes which is possible the favorable tendency. Inside the process gradual and steady changing from drug sensitive on drug resistant Mycobacterium tuberculosis population has taken place that has the consequence various organizational and medical complexities of therapy of the patients. Simultaneously population of tuberculosis patients is also change with increasing the proportion of patients with a combination of tuberculosis and HIV-infection. Lacks of HIV early detection, growth of HIV patients with prolonged stages of HIV and wide spreading of tuberculosis contamination among population become the reason of fast transformation latent tuberculous infection to disease. Antiviral therapy actively appointed to HIV patients does not render influence on this process yet.