Vol 4, No 4 (2022)

In our opinion, the ability to prevent or avoid negative impact on the environment by pharmaceutical industry organizations in normal situations fully depends on the environmental management system of the quality management system of the production enterprise. During the work, according to the set goals and objectives, an analysis of the accounting and reporting documentation of pharmaceutical manufacturers was carried out based on environmental international and domestic regulatory acts and documents in the paradigm of sustainable development. We have proposed a Conceptual project of an environmental management system in the form of a block diagram of nature conservation documentation for category II hazardous waste facilities of pharmaceutical biotechnology enterprises. Individual documents and document templates were developed in such a way as to cover the most common accounting and reporting documents filled out by a pharmaceutical industry production enterprise based on principles of social responsibility in environmental protection. It is necessary to note the relevance of introducing and balancing non-financial and financial reporting in the quality management system of pharmaceutical production enterprises, taking into account their social responsibility and personnel work. The results obtained can be used in the quality management system of pharmaceutical industry organizations - drug manufacturing enterprises using biological and chemical technologies when implementing projects during the development of nature conservation documentation for environmental management system projects with the aim of developing a project for social responsibility and non-financial reporting, not just for public joint-stock companies.

In our study, the following are modern information about the structural and functional organization of cell membranes, the internal apparatus, as well as the cell organelle. The features of the functioning of the structural and dynamic genome are shown, including the main epigenetic mechanisms of gene expression regulation. The cell pathology section describes the main pathological processes that occur in cells after reversible and irreversible damage. The mechanisms and signaling pathways of the phenomenon, markers of cellular aging are highlighted, as well as the significance of this phenomenon in normal and pathological conditions. The main mechanisms of hypoxic and free-radical necrobiosis are described. The mechanisms, signaling pathways, and significance for the norm and pathology of two types of programmed cell death, autophagy and apoptosis, are discussed in detail. The prospect of using fundamental knowledge about the molecular mechanisms of life activity to improve the treatment of the most urgent types of pathology is shown.

Nowadays, feeding honeybees is not only considered a way to provide them with energy, but also as a factor that affects the normal functioning of all the bee’s body systems and the prevention of various diseases. This study investigated the quality of natural and artificial carbohydrate feed for honeybees, as well as presented data on their digestibility in the conditions of the northwestern region of the European part of Russia. A correlation was found between the digestibility of carbohydrate feeds and the weight of the rectum of worker bees at the end of the wintering period before the first flight. The methodology for conducting the research was also presented. The authors concluded on the prospects of studying the digestibility of carbohydrate feed, as well as determining the amount of honeydew and the speed of honey crystallization, as important components of the organization and planning of wintering of honeybees and improving beekeeping technology.

The lecture describes the morphofunctional organization of the sound-conducting and sound-receiving structures of the auditory analyzer. The most common types of pathology that lead to impaired functions of the hearing organ are described. Causes and mechanisms of development of two main types of hearing impairment – conductive and sensorineural hearing loss are highlighted. Modern hardware complexes and operational technologies are shown, which are used for the diagnosis and treatment of conductive hearing disorders. Causes and mechanisms of sensorineural hearing loss are highlighted. Microelectronic devices (cochlear implants) and the technology of their transplantation into the affected hearing organ are described. The characteristics of hearing aids, which are most often recommended by experts to patients of various ages with hearing impairment, are given.

Approaches to sustainable development of food production and agriculture are being considered, taking into account ecological, social, and economic aspects. Special attention is paid to the development of beekeeping on post-agricultural lands in the North-West Federal District of Russia and its potential in solving the problems raised in the General Assembly of the United Nations on sustainable development and the Strategy for Improving the Quality of Food Products in the Russian Federation until 2030. Developing beekeeping is an important factor in the sustainable development of food production and agriculture, contributing to regional development and solving the problems raised in the General Assembly of the United Nations on sustainable development. In our opinion, the development of beekeeping and related industries on abandoned agricultural lands can solve many problems at the regional, national, and global levels. These problems are related to sustainable deve lopment, ensuring food security, environmental sustainability, and social issues.

The present essay is dedicated to one of the most famous evolutionary biologists of recent decades, Thomas Cavalier-Smith, one of the founders of eukaryotic megasystematics. His theoretical work was devoted to various aspects of the origin of the cell and the evolution of the genome, and the main thing was the improvement of eukaryotic megasystematics. Cavalier-Smith’s thinking style was characterized by a detailed elaboration of data from various disciplines, including cell biology, biochemistry, molecular evolution, protistology, microbiology, and paleontology. He had an encyclopedic outlook, a lively mind and was alien to dogmatism. His peculiar cognitive method was to put forward and then test extravagant evolutionary hypotheses. The theoretical heritage of Cavalier-Smith has influenced several generations of researchers and the landscape of modern theoretical biology. The life of Cavalier-Smith is a perfect example of endless dedication and a sense of professional duty.