Pharmacy Formulas

A periodical scientific publication, the journal " Formulas of Pharmacy "(hereinafter-the publication), for publishing the main scientific results of dissertations for the degree of candidate of Sciences, for the degree of doctor of Sciences; presents high-quality, peer-reviewed research and interactive clinical content.

Our journal is focused on clinical pharmacologists, specialists of expert organizations, workers centers preclinical and clinical trials of medicinal products; employees of regulatory and Supervisory organizations and institutions in the field of pharmaceutical industry and Russian Ministry of health; researchers, medical and pharmaceutical workers of the organisations and institutions of the Ministry of health; experts of the scientific organizations of RAS and other researchers in the field of environmental security.

The topics of published materials are limited to two branches of science - medical and biological - and they correspond to groups of scientific specialties (03.02.00 General biology, 14.03.00 Biomedical sciences, 14.04.00 Pharmaceutical sciences) in accordance with the order of the Ministry of Education of the Russian Federation dated October 23, 2017 No. 1027 "On the approval of the nomenclature of scientific specialties for which science degrees are awarded" and by order of the Ministry of Education and Science of the Russian Federation of December 12, 2016 No. 1586 (revised March 27, 2018) "On the approval of the rules for forming the list of peer-reviewed scientific publications."

The publication complies with modern rules and requirements of domestic and foreign legislation for peer-reviewed scientific publications.

Journal strategy

When preparing each issue, members of the editorial Board intend to take into account modern requirements for the order of qualified review, information openness and bibliometric indicators in assessing the publication activity of authors, along with other factors of the journal.

To this end, the editorial team uses rigorous: editorial, expert, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance; policies and practices that ensure that authors disclose all relevant financial associations and that such associations do not in any way affect the content published by the journal.

When developing the strategy and layout of the publication, we studied and analyzed the professional materials available to us from information resources of publishers and owners of bibliographic and abstract databases-leaders of international citation systems for relevant branches of science and groups of scientific specialties.

In the course of this work, three groups of scientific specialties were identified, which, in our opinion, made it possible to create a publication's rubricator and determine its name: "Pharmacy Formulas". At the same time, we took into account the definition of pharmacy as the entire life cycle of medicines, including the creation, preclinical and clinical research, production technology, organization of pharmaceutical business, as well as issues of control and analytical research, food and environmental safety. In turn, the word "formulas" means directions, trends, trends in the development of scientific and practical areas that make up pharmacy.

We believe that through our efforts, the journal will keep healthcare and pharmaceutical industry professionals at the forefront of medical and pharmaceutical knowledge, help them deepen their understanding of new areas of interest, and provide valuable insights into scientific and practical medical and pharmaceutical activities.

Authors and readers

To present the results of high-quality scientific research to the reader, we are ready to be responsible for preparing the manuscript to meet the requirements of the journal, quality review of manuscripts , preparing the article for publication, providing opportunities and scientific communications of the founders of the publication to promote the article.

The journal's website meets all the requirements of the international bibliographic database. Full electronic document flow for authors, reviewers, scientific and literary editors is carried out on our own platform.

To promote the article, authors will be able to use the personal website of the publication; assignment of the DOI identifier of the author's manuscript immediately after uploading to the site; unique author ID ORCID; professional social networks Google Scholar, ResearchGate; repositories; open electronic archives; bibliography management system; social media; registration of the scientist as a reviewer; assistance in preparing the use of media (materials for press releases, interviews).

The publishing house of the journal has direct channels for transmitting information to the RSCI and international databases: Scopus, Web of Science, PubMed, CNKI.

When developing all the tasks facing the members of the editorial Board and editorial Board of the journal "Formulas of Pharmacy", we share a common goal: to promote and actively participate in scientific communications on the declared groups of scientific specialties in the biomedical field and pharmacy, from the idea to the release of medicines to the consumer market and management of their waste and metabolites.

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Current Issue

Vol 5, No 4 (2023)

Pharmaceutical Sciences

The antiarrhythmic activity of amino acid-containing derivatives of 1,4-naphthoquinone
Napalkova S.M., Buyuklinskaya O.V.
Abstract

In recent times, the issue of cardiac arrhythmia disturbances has garnered increasing attention from researchers. Pharmacotherapy continues to be the primary method for treating rhythm disturbances; however, its effectiveness is often limited due to the common side effects associated with many antiarrhythmic drugs, among which negative inotropic action plays a significant role. One direction in the development of antiarrhythmic agents involves the targeted search for new drugs among agents with metabolic effects. The aim of this study was to investigate the antiarrhythmic activity using models of occlusion and reperfusion arrhythmias in cats, aconitine arrhythmias in rats, and calcium chloride ventricular fibrillation in rats of five original amino acid-containing derivatives of 1,4-naphthoquinone, synthesized at the Lviv Polytechnic Institute under the guidance of Ph.D. A.P. Kartoflitska. The conducted research indicated that the studied compounds exhibit antiarrhythmic effects. The enhancement of the antiarrhythmic activity occurred primarily in those arrhythmia models where metabolic disorders play a significant role in the pathogenesis.

Pharmacy Formulas. 2023;5(4):10-15
pages 10-15 views

Biomedical Sciences

The state of cancer care in Russia: age and cancer. Features of the localization structure, quality of accounting and survival of patients with malignant neoplasms of senile age and centenarians (population study). Part 5
Merabishvili V.M., Shakhzadova A.O., Perelygin V.V.
Abstract

In accordance with the World Health Organization (WHO) standard, the elderly population is defined as individuals aged 75 to 89, while long-livers are those aged 90 and older. According to the United Nations, long-livers are individuals who have reached 100 years of age. In the preceding four messages, we explored the specific detailed localization structure of morbidity, mortality, and survival in pediatric, adolescent, young adult, middle-aged, and elderly populations. However, the analysis of these characteristics for individuals in the elderly and long-liver categories is conducted for the first time. Old age is the period of human life characterized by the loss of the body's ability to sustain the species, deterioration of mental capacities, and decline in bodily functions. It represents an age range for individuals nearing the expected life span. Gerontologists are concerned with medical research into the aging process, while diseases affecting the elderly and old age fall under the purview of geriatrics. The discipline of gerontology deals with the technologies for supporting an aging society. The elderly and older adult populations are more susceptible to diseases and injuries. They face economic challenges related to retirement, loneliness, and ageism – age-based discrimination. The WHO's definition of "elderly" encompasses three five-year age groups, including long-livers: - 75-79 years – early old age - 80-84 years – advanced old age - 85-89 years – late old age - 90 years and older – long-livers. We will attempt to examine the specific localization characteristics and the potential effectiveness of specialized oncological care for each of these age groups. Emphasis will also be placed on the quality of primary patient registration whenever possible.

Pharmacy Formulas. 2023;5(4):16-32
pages 16-32 views

Biological sciences

Glucans and heteroglycans of fungi and their potential in cancer immunotherapy
Zmitrovich I.V., Perelygin V.V., Zharikov M.V.
Abstract

The present review is devoted to the oncostatic properties of glucans and heteroglycans produced by higher fungi. These are the most pharmacologically promising substances, since they are produced in large quantities both by artificially grown mycelium and fruiting bodies, do not require complex purification methods, are devoid of toxicity, and, having a complex (immune-mediated and direct) effect on tumors, do not require any complex fractionation procedures. The diversity of β-glucans produced by fungi is shown, the main types of these macromolecules are considered (according to the structural features of the macromolecule, the linear and branched forms of β-glucans are distinguished, first of all). Heteroglycans, a more diverse but less studied group of fungal compounds, have also been characterized. The effects of fungal β-glucans and heteroglycans on immune and cancer cells described in the literature are considered. The long and branched chains of these biopolymers, as well as peptides and lipids covalently bound to them, have fragments that are complementary to the binding sites of the surface receptors of the animal cell and thus act as their agonists or antagonists. They are recognized by the receptors of antigen-representing cells of the immune system as pathogen-associated molecular patterns, what leads to the activation of the cytotoxic component of the immune system; to reduce their tolerogenic and immunosuppressive signaling. Prospects for further study of fungal glucans and heteroglycans are outlined.

Pharmacy Formulas. 2023;5(4):34-45
pages 34-45 views

Actual problems: discussion tribune

The influence of short-term heating on the activity of amylolytic enzymes in honey
Solovyova V.V., Tikhomirov V.A., Filatova K.A., Paramonov S.G.
Abstract

This study presents the results of the analysis of the activity of amylolytic enzymes in honey, depending on short-term heating, simulating the process of adding honey to hot tea. Additionally, a comparison of this activity with similar enzymes present in the pharmaceutical preparation "Festal" was conducted. Regularities in the change of amylolytic enzyme activity were established, contributing to the development of recommendations for honey consumption considering this parameter. The obtained results demonstrate significantly lower activity of amylolytic enzymes in honey compared to the pharmaceutical preparation. However, considering differences in consumption, it is possible to assess them as comparable. It was also revealed that the activity of amylolytic enzymes in honey changes during short-term heating, not decreasing until the temperature reaches 30°C. Based on the in vitro activity analysis, the tested sample corresponds to the pharmaceutical preparation "Festal," allowing for prospects for further research into the impact of honey's amylolytic enzymes on the human body, requiring more precise methods of study. 

Pharmacy Formulas. 2023;5(4):46-51
pages 46-51 views
Microbiological studies of juniper extract to determine sensitivity to strains of microorganisms
Ivanova K.O., Lunegov A.M., Chernykh T.F., Zenkov K.F.
Abstract

Juniper is a widely used resource in the food, cosmetic, and medical industries. However, its application in veterinary medicine represents a less researched area. Literature studies confirm the presence of terpenoid compounds, tannins, ketones, sugars, organic acids, and flavonoids in juniper. Determination of the chemical composition of juniper essential oil revealed the prevalence of terpenes such as α-pinene, β-pinene, ocimene, and α-limonene, with variations depending on the species and habitat of the plant. Analysis of the literature data highlights the significant importance of α-pinene, serving as the primary and most studied terpene in juniper essential oil with notable diuretic properties. Furthermore, juniper essential oil possesses antibacterial, antifungal, anti-inflammatory, and deodorizing properties. The aim of the study was to reassess the antimicrobial and antifungal properties of the extract obtained from common juniper fruits through extraction. The research used extracts of essential oils obtained from common juniper fruits and tested them for antibiotic activity against microorganisms of various taxonomic groups. The experiment was conducted in accordance with sanitary and epidemiological requirements and federal clinical recommendations. The research methodology included serial dilutions, preparation of microbial suspensions, inoculation of nutrient media, incubation, and result assessment. 

Pharmacy Formulas. 2023;5(4):52-56
pages 52-56 views

Heritage

Life path of Leonid Vasilyevich Dmitrenko
Glazova N.V., Berdnikova Y.L.
Abstract

The essay is dedicated to Leonid Vasilyevich Dmitrenko, a Soviet and Russian scientist and specialist in the field of chemical physics, whose scientific, pedagogical, and organizational activities unquestionably laid the foundation for further development in the area of high-molecular compounds and their industrial production. Leonid Vasilyevich was an outstanding scientist and researcher, distinguished by his intellectualism, kind attitude towards colleagues and students, and his concern for people's problems, providing invaluable assistance and support to those in need. Bright memories of Leonid Vasilyevich will forever remain in the hearts and minds of his relatives, coworkers, and students and graduates of the university. This essay is written with the support of Leonid Vasilyevich's daughter, Julia Leonidovna Berdnikova, who was able to provide materials from her family's archives.

Pharmacy Formulas. 2023;5(4):62-69
pages 62-69 views
Half a Century in Service: Professor Leonid Gerasimovich Marchenko (1941–2019)
Flisyuk E.V., Marchenko A.L.
Abstract

This text is a dedication to the Professor Leonid Gerasimovich Marchenko, a graduate of the Leningrad Institute of Chemical-Pharmaceutical Sciences. Throughout his career in education, L.G. Marchenko progressed from being an assistant to eventually heading the Department of Pharmaceutical Technology of Medications. Apart from his teaching activities, he was actively involved in administrative work: serving as deputy dean, and from 1983 to 1986, as the dean of the Pharmaceutical Faculty; from 1986 to 2005, he was the Vice-Rector for Academic Affairs, then from 2005 to 2008, the First Vice-Rector for Academic Affairs, and from 2008 to 2009, an advisor to the rector. The essay draws on family archival materials, thanks to the active support of Ekaterina Anatolievna Marchenko, who carefully preserves the memory of her husband, L.G. Marchenko. For almost half a century, Leonid Gerasimovich's life was inseparably linked to the Saint Petersburg State Chemical-Pharmaceutical University. Here he studied from his student years, continued his education in graduate school, and then worked in the university for more than 40 years. Leonid Gerasimovich embodied the principles of academic integrity and responsibility. He always attached great importance to the quality of his work, sought perfection, and inspired his colleagues to achieve high results.

Pharmacy Formulas. 2023;5(4):70-75
pages 70-75 views


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