Mechanisms of prevention postoperative immunosuppression by regional anesthesia

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The data on the factors of development of postoperative immunosuppression (PI) are presented. Among them, an important role in the development of PI belongs to hyperactivity during operations of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal system. It has been shown that PI is prevented by regional anesthesia, primarily epidural anesthesia and postoperative epidural analgesia, as well as prolonged ganglioplegia. It is concluded that the preventive action of regional anesthesia in relation to the development of PI is largely associated with the sympatholytic component of action.

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About the authors

Oleg N. Zabrodin

Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.

Dr. Sci. (Med.)

Russian Federation, 6-8, Lev Tolstoy str., 197022, Saint Petersburg

Viktor I. Strashnov

Academician I.P. Pavlov First St. Petersburg State Medical University


Dr. Sci. (Med.), Professor

Russian Federation, 6-8, Lev Tolstoy str., 197022, Saint Petersburg


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