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Asymmetry in the content of brain monoamines of BALB/c mice reared in social isolation conditions
- Authors: Karpova I.V.1, Mikheyev V.V.2, Bychkov Y.R.3, Lebedev A.A.3, Shabanov P.D.3
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Affiliations:
- I. P. Pavlov State Medical University
- S. M. Kirov Military Medical Academy
- Institute of Experimental Medicine NWB RAMS
- Issue: Vol 10, No 4 (2012)
- Pages: 42-48
- Section: Articles
- URL: https://journals.eco-vector.com/RCF/article/view/748
- DOI: https://doi.org/10.17816/RCF10442-48
- ID: 748
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Abstract
The effects of long-term social isolation on the content and metabolism of dopamine and serotonin systems were studied in symmetrical brain structures of BALB/c male mice. With HPLC the contents of dopamine (DA), serotonin (5-HT) and their metabolites dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindolacetic acid (5-HIAA) were measured in the cortex, hippocampus and striatum of both the right and the left hemispheres of the brain in mice reared in groups and social isolation. The isolated mice were characterized by reduced level of DA in the left striatum and elevated level of 5-HIAA and ratio 5-HIAA/5-HT in the right striatum. In the hippocampus of isolated mice, the activation of both DA-ergic and 5-HT-ergic systems was observed, that is the high level of DA and DOPAC in the left hippocampus and the elevated level of 5-HT in both hemispheres and of 5-HIAA in the right hippocampus were registered. On the other hand, the reduction of both DA-ergic and 5-HT-ergic systems activity was shown to be in the right hemisphere. The decreased concentration of DOPAC and ratio DOPAC/DA in the right cortex were observed as well. As to 5-HT-ergic system, the reduced level of 5-HT in the both cortex of the hemispheres as well as 5-HIAA in the right hemisphere of isolated mice was determined. The phenomenon of interhemispheric asymmetry was revealed in the hippocampus only, which was characterized by the increased DA-ergic activity in the left hippocampus but not in the striatum and the cortex.
About the authors
Inessa Vladimirovna Karpova
I. P. Pavlov State Medical University
Email: inessa.karpova@gmail.com
PhD (Physiology), Assistant Professor, Dept. of Normal Physiology
Vladimir Vladimirovich Mikheyev
S. M. Kirov Military Medical Academy
Email: vmikheev58@gmail.com
Doctor of Biol. Sci. (Pharmacology), Assistant Professor, Dept. of Pharmacology
Yevgeniy Rudolfovich Bychkov
Institute of Experimental Medicine NWB RAMSPhD (Pathophysiology), Senior Researcher, S. V. Anichkov Dept. of NeuroPharmacology
Andrey Andreyevich Lebedev
Institute of Experimental Medicine NWB RAMS
Email: aalebedev-iem@yandex.ru
Doctor of Biol. Sci. (Pharmacology), Professor, Senior Researcher, S. V. Anichkov Dept. of NeuroPharmacology
Petr Dmitriyevich Shabanov
Institute of Experimental Medicine NWB RAMS
Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor, Head, Dept. of Neuropharmacology
References
- Будилин С. Ю., Мидзяновская И. С., Шеголевский Н. В., Иоффе М. Е., Базян А. С. Асимметрия содержания дофамина в прилежащем ядре и моторное предпочтение у крыс // Журнал высшей нервной деятельности им. И. П. Павлова. — 2007. — Т. 57, № 5. — С. 598–603.
- Лебедев А. А., Бычков Е. Р., Николаев С. В. и др. Влияние фенамина на содержание дофамина, норадреналина, серотонина и их метаболитов в дофаминергических структурах мозга крыс с различным индивидуальным опытом // Наркология. — 2002. — Т. 1, № 12. — С. 2–6.
- Михеев В. В., Бианки В. Л., Пошивалов В. П. Влияние односторонней корковой распространяющейся депрессии на внутривидовую агрессию и общительность изолированных мышей // Журнал высшей нервной деятельности. — 1987. — Т. 37, № 5 — С. 964–960.
- Михеев В. В., Шабанов П. Д. Фармакологическая асимметрия мозга. — СПб: Элби-СПб, 2007. — 384 с.
- Пошивалов В. П. Экспериментальная психофармакология агрессивного поведения // Л.: Наука, 1986. — 178 с.
- Раевский К. С., Сотникова Т. Д., Гайнетдинов Р. Р. Дофаминергические системы мозга: рецепторная гетерогенность, функциональная роль, фармакологическая регуляция // Успехи физиол. наук. — 1996. — Т. 27, № 4. — С. 3–29.
- Шабанов П. Д., Лебедев А. А. Зоосоциальное поведение крыс // Обзоры по клин. фармакол. и лек. терапии. — 2007. — Т. 5, № 3. — С. 2–79.
- Шабанов П. Д., Русановский В. В., Лебедев А. А. Зоосоциальное поведение млекопитающих. — СПб: Элби-СПб, 2006. — 160 с.
- Andersen S. L., Dumont N. L., Teicher M. H. Differences in behavior and monoamine laterality following neonatal clomipramine treatment // Dev. Psychobiol. — 2002. — Vol. 41, N 1. — P. 50–57.
- Berridge C. W., Mitton E., Clark W., Roth R. H. Engagement in a non-escape (displacement) behavior elicits a selective and lateralized suppression of frontal cortical dopaminergic utilization in stress // Synapse. — 1999. — Vol. 32, N 3. — P. 187–197.
- Carlson J. N., Drew S. K. Individual differences in ethanol self-administration following withdrawal are associated with asymmetric changes in dopamine and serotonin in the medial prefrontal cortex and amygdala // Alcohol Clin. Exp. Res. — 2006. — Vol. 30, N 10. — P. 1678–1692.
- Castellano A., Diaz-Palarea M. D., Rodrigues M., Barroso G. Lateralization in male rats and dopaminergic system: evidences of right-side population bias // Physiol. Behav. — 1987. — Vol. 40. — P. 607–612.
- Diaz P., Gonzales M. C., Rodrigues M. Behavioral lateralizationin the T-maze and monoaminergic brain asymmetries // Physiol. Behavior — 1987. — Vol. 40, N 6. — P. 785–789.
- Fabricius K., Steiniger-Brach B., Helboe L., Fink-Jensen A., Wörtwein G. Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia // Int. J. Dev. Neurosci. — 2011. — Vol. 29, N 3. — P. 347–350.
- Glick S. D., Jerussi J. P. Spatial and paw preferences in rats: their relation to rate-dependent effects of d-amphetamine // J. Pharmacol. Exp. Ther. — 1974. — Vol. 188. — P. 714–725.
- Glick S. D., Shapiro R. M. Functional and neurochemical mechanism of cerebral lateralization in nonhuman species // Orlando: Acad. Press, 1985. — P. 57–183.
- Han X., Li N., Xue X., Shao F., Wang W. Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats // Brain Res. — 2012. — Vol. 1447. — P. 38–43.
- Jones G. H., Hernandez T. D., Kendall D. A., Marsden C. A., Robbins T. W. Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry // Pharmacol. Biochem. Behav. — 1992. — Vol. 43, N 1. — P. 17–35.
- Krasnova I. N., Bychkov E. R., Lioudyno V. I., Zubareva O. E., Dambinova S. A. Intracerebroventricular administration of substance P increases dopamine content in the brain of 6-hydrodopamine lesioned rats // Neuroscience. — 2000. — Vol. 95, N 1. — P. 113–117.
- Levin E. D., Rose J. E. Acute and chronic nicotinic interaction with dopamine systems and working memory performance // Ann. NY Acad. Sci. — 1995. — Vol.757 — P. 245–252.
- Nielsen D. M., Crosley K. J., Keller R. W., Glick S. D., Carlson J. N. Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats // Brain Res. — 1999. — Vol. 823, N 1–2. — P. 207–212.
- Packard M. G., White N. M. Dissociation of hippocampus and caudate nucleus memory systems by post-training intracerebral injection of dopamine agonists // Behav. Neurosci. — 1991. — Vol. 105. — P. 295–306.
- Sullivan R. M., Dufresne M. M. Mesocortical dopamine and HPA axis regulation: role of laterality and early environment // Brain Res. — 2006. — Vol. 1076, N 1. — P. 49–59.
- White N. M., Packard M. G., Seamans J. Memory enhancement by post-training peripheral administration of low doses of dopamine agonists: possible autoreceptor effect // Behav/Neural Biol. — 1993. — Vol. 55. — P. 230–241.
- White N. M., Viaud M. Localized intracaudate dopamine D2 receptor activation during the post-training period improves memory for visual or olfactory conditioned emotional responses in rats // Behav. Neural Biol. — 1991. — Vol. 55. — P. 255–269.
