Vol 10, No 3 (2012)

With the goal to study peculiarities of functional asymmetry of the brain hemispheres in alcohol dependence, there has been done an analysis of current research data from Russian and foreign studies. It has been shown that alcohol is a neurochemical modulator of interhemispheric relations, it affects functional asymmetry of the brain hemispheres, perception processes, changes emotional background, influences motor asymmetry, the brain cortex functional activity. Alcohol intoxication is described by the right hemisphere lateralization and a laterodeviation of the brain hemispheres’ functional asymmetry to the left hemisphere. Studies of adolescents with beer alcoholization have shown left sided laterodeviation of functional asymmetry with dominating left-sided lateralization of motor signs, increased delta activity of the brain biorhythms. The received data indicate a substantial breach of functional asymmetry in alcohol users, in what connection the breach involve the motor and sensory levels.

In experiments on mice undergone to an acute hypercapnic hypoxia and an acute hypobaric hypoxia a screening of antihypoxants among new selenium containing metal complex substances was performed after their intra-abdominal and oral introductions. It was found that substances πQ1983 and πQ2170 on both models of hypoxia make the defensive effects surpassing actions well-known antihypoxants such as amthizole and bemythil. It was shown that antihypoxiс affects of studied substances depend on their caused hypothermia. For the first time the protective action of selenium containing metal complex compounds was demonstrated after their introduction per os.

A brief review of the N. V. Lazarev school study of the pharmacological properties of the classical phytoadaptogens. As the result of this research was creation a theory of state nonspecific body increased resistance induced by phytoadaptogens, and the discovery of their stress-limiting properties. Presented own data of first time comparative evaluation of anti-stress action of phytoadaptogens in the model of immobilization stress. Revealed in own clinical studies a high efficiency of polycomponent phytotherapy, including a large number of phytoadaptogens in the treatment of patients with multiple sclerosis.

As clinical test material we studied the blood serum taken from clinically healthy animals (the control group) and animals with chronic inflammation of the connective tissue in an ankle joint (the experimental group). To study the antioxidant protection system enzyme component condition in cows we examined the following: catalase and glutathione peroxidase activity (as a substrate we used hydrogen dioxide and glutathione reductase), ferroxidase activity of ceruloplasmin, superoxide dismutase activity. A spectrocolorimeter «Specol 210» was used to determine the solutions absorbancy. The results shows the breakdown of membrane-bounded enzymes activity (such as glutathione reductase and superoxide dismutase). These enzymes characterize the antioxidant protection system condition. It is essential to examine the antioxidant protection system condition in animals with chronic inflammation of the connective tissue in an ankle joint to enrich our knowledge about the mechanism of metabolic disorder at this type of pathology, as well as to treat and correct possible complications.