ESTROGEN LEVEL AND RISK OF CARDIOVASCULAR EVENTS IN OLDER WOMEN



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Abstract

Introduction: Estrogens play an important role in the physiology of the reproductive, cardiovascular, skeletal and central nervous systems. However, there is limited literature data on the correlation between estrogen levels and the risk of cardiovascular events in the elderly.re contradictory.

Objective: To evaluate the effect of estrogen levels on the incidence of myocardial infarction (MI) and stroke in older women.

Materials and methods: A population-based cross - sectional cohort Crystal study of community-dwelling individuals 65+ (n=280). Main study parameters: survey and analysis of medical records for data on non-communicable chronic diseases, laboratory tests (estradiol, thyroid-stimulating hormone, glycated hemoglobin, total protein, albumin, lipid panel, C-reactive protein, complete blood count test, creatinine).

Results: A history of stroke was recorded in 18.9% (n=54) and MI – in 11.9% (n=34). In study participants with estradiol levels above the 4th quintile (>55 pmol/l), after adjustment for age and HDL levels, stroke was recorded 2.5 times more often [odds ratio (95% confidence interval) 2.480 (1.180 - 5.211)], and MI was recorded 2 times more often [odds ratio (95% confidence interval) 2.003 (1.088 - 3.687)].

Conclusion: Estradiol level >55 pmol/l is an independent risk factor for the development of stroke and МШ in women aged 65 years and older

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About the authors

Anna Turusheva

I.I. Mechnikov North-Western State Medical University, St. Petersburg

Author for correspondence.
Email: anna.turusheva@gmail.com
ORCID iD: 0000-0003-3347-0984
SPIN-code: 9658-8074

PhD, MD, DSc, Professor of Department of Family Medicine

Russian Federation

Ksenia Anatolyevna Panchishina

The North-Western State Medical University named after I.I. Mechnikov" St. Petersburg, Russia

Email: panchishina00@mail.ru
ORCID iD: 0000-0003-2489-4048
SPIN-code: 5778-9251

1st year resident of the Department of Family Medicin

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