Perspectives of micronuclear test in human lymphocytes cultivated in cytogenetic block conditions. Part 1: Cell proliferation



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Cultivation of human blood lymphocytes under the conditions of cytokinetic block with cytochalasin B creates unique opportunity to analyze the total spectrum of the changes describing genome instability. The main task of the present publication is the analysis of a modern state, opportunities and outlooks of the micronuclear test on human blood lymphocytes. The special attention is given those directions of researches which are rather seldom present in the literature - to laws of cellular proliferation, to existence of physiological conditionality and genetic predisposition to development of effects of genome instability; to effects of emotional stress and the adaptive response to action of ionizing irradiation, etc. The material is presented in 2 consecutive publications. It is finished with discussion of methodical features of statement of culture, results of the microscopic analysis and ideology of creation of the conclusions of the study.

About the authors

Faina I Ingel

A.N. Sysin Scientific Research Institute of Human Ecology and Hygien of Environment, Moscow, RF

Email: fainaingel@mail.ru

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