Obstetric and perinatal risks after new coronavirus infection
- Authors: Medyannikova I.V.1, Kuklis Y.C.2, Savelyeva I.V.1, Beznoshchenko G.B.1, Galyanskaya E.G.1, Tsygankova O.Y.1, Prodanchuk E.G.1, Bukharova E.A.1, Nosova N.V.1, Davydov P.V.1
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Affiliations:
- Omsk State Medical University
- Infectious Disease Clinical Hospital No. 2
- Issue: Vol 72, No 5 (2023)
- Pages: 49-60
- Section: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/303667
- DOI: https://doi.org/10.17816/JOWD303667
- ID: 303667
Cite item
Abstract
BACKGROUND: Numerous studies indicate that pregnant women are at risk for severe morbidity, adverse gestational outcomes, and mortality following COVID-19. These patients have a higher frequency of miscarriage at various stages of gestation, premature birth, preeclampsia, cesarean section, and birth of children with low body weight. Other publications have suggested that the clinical characteristics of the disease detected in pregnant women with confirmed COVID-19 are similar to those in the general population.
AIM: The aim of this study was to determine obstetric and perinatal risks in women who have had COVID-19 during pregnancy.
MATERIALS AND METHODS: We conducted an open prospective continuous cross-sectional study in which 114 patients were examined after suffering from COVID-19. Depending on the severity of the new coronavirus infection, they were divided into groups: group I (n = 36) included patients with mild disease, group II (n = 56) – with moderate disease, group III (n = 22) – with heavy. The control group consisted of 93 pregnant women who were hospitalized during the specified period without COVID-19 and signs of acute respiratory viral infection.
RESULTS: Gestational diabetes mellitus is associated with a risk of the moderate and severe new coronavirus infections during pregnancy. Placental deficiency is significantly more often recorded in moderate and severe COVID-19 cases. Severe COVID-19 in pregnant women determines a high probability of fetal growth restriction. Preeclampsia complicates pregnancy in all patients with either mild, moderate, or severe COVID-19. The risk of premature birth with a high probability is determined by the moderate and severe courses of the disease. Only moderate COVID-19 during pregnancy is associated with the risk of induced labor. The risk of operative delivery by cesarean section is significantly increased in moderate and severe COVID-19. Moderate and severe courses of the underlying disease during pregnancy determine a high probability of low body weight of children at birth. The risk of hospitalization in the resuscitation unit is associated with moderate and severe COVID-19 during pregnancy.
CONCLUSIONS: Maternal mortality among women with COVID-19 who were hospitalized in an obstetric hospital was 3,636 per 100,000 live births. Perinatal mortality in patients who suffered a new coronavirus infection during pregnancy was 52.6‰.
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About the authors
Irina V. Medyannikova
Omsk State Medical University
Email: mediren@gmail.com
ORCID iD: 0000-0001-6892-2800
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, OmskYulia Ch. Kuklis
Infectious Disease Clinical Hospital No. 2
Email: miss.kuklis@mail.ru
ORCID iD: 0000-0003-4155-0597
MD
Russian Federation, MoscowIrina V. Savelyeva
Omsk State Medical University
Email: savelyeva_iv_omsk@mail.ru
ORCID iD: 0000-0001-9342-7342
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, OmskGalina B. Beznoshchenko
Omsk State Medical University
Email: akusheromsk@rambler.ru
ORCID iD: 0000-0002-6795-1607
MD, Dr. Sci. (Med.), Professor
Russian Federation, OmskElena G. Galyanskaya
Omsk State Medical University
Email: galaynskaya@mail.ru
ORCID iD: 0000-0002-9603-7363
MD, Cand. Sci. (Med.)
Russian Federation, OmskOlga Yu. Tsygankova
Omsk State Medical University
Email: olts74@mail.ru
ORCID iD: 0000-0002-3553-055X
MD, Cand. Sci. (Med.)
Russian Federation, OmskEvgeny G. Prodanchuk
Omsk State Medical University
Email: ompeg@mail.ru
ORCID iD: 0000-0003-4498-5836
MD, Cand. Sci. (Med.)
Russian Federation, OmskElena A. Bukharova
Omsk State Medical University
Email: buxarova88@mail.ru
ORCID iD: 0000-0002-6093-3721
MD
Russian Federation, OmskNatalya V. Nosova
Omsk State Medical University
Email: natalya-nosova-85@mail.ru
ORCID iD: 0000-0002-2362-5367
MD
Russian Federation, OmskPavel V. Davydov
Omsk State Medical University
Author for correspondence.
Email: pavada2@mail.ru
ORCID iD: 0000-0001-6867-7024
MD
Russian Federation, OmskReferences
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