Clinical features of labor and morphological aspects of the myometrium receptor profile in obese women
- Authors: Seryogina D.S.1, Mozgovaya E.V.1,2, Tral T.G.1,3, Tolibova G.K.1,4, Sotnikova L.K.1
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Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- Saint Petersburg State University
- Saint Petersburg State Pediatric Medical University
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 70, No 5 (2021)
- Pages: 73-82
- Section: Original Research
- Submitted: 17.03.2021
- Accepted: 15.09.2021
- Published: 02.11.2021
- URL: https://journals.eco-vector.com/jowd/article/view/63529
- DOI: https://doi.org/10.17816/JOWD63529
- ID: 63529
Cite item
Abstract
BACKGROUND: Obesity is currently considered as one of the most significant social chronic diseases. It has been proven that obese pregnant women are more likely than women with normal body weight to experience complications of pregnancy and labor. The most frequent complications of labor in obese women are weakness and discoordination, which are probably associated with a decrease in the sensitivity of the myometrium to oxytocin, due to suppression of oxytocin receptor expression.
AIM: The aim of this study was to explore the clinical features of labor and morphological aspects of the myometrium receptor apparatus in obese women.
MATERIALS AND METHODS: We performed a prospective assessment of labor activity in women with obesity, with a combination of obesity and gestational diabetes mellitus and in healthy women. We also conducted a morphological study of myometrium biopsies obtained during cesarean section.
RESULTS: Obese patients are more likely to experience various complications of pregnancy and labor, which is the reason for the higher frequency of operative delivery. Patients with obesity showed lower expression of oxytocin receptors in the lower segment of the uterus, which, apparently, is the cause of abnormal contractility of the myometrium during labor and the lack of effect from drug correction of this condition.
CONCLUSIONS: The presence of obesity in women before pregnancy contributes to frequent complications of pregnancy and labor, abnormal uterine contractility related to the decreased oxytocin receptor expression, and a high incidence of surgical delivery.
Full Text
About the authors
Darya S. Seryogina
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Author for correspondence.
Email: d.sereogina2010@yandex.ru
ORCID iD: 0000-0002-6496-586X
SPIN-code: 2852-3281
MD
Russian Federation, Saint PetersburgElena V. Mozgovaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State University
Email: elmozg@mail.ru
ORCID iD: 0000-0002-6460-6816
SPIN-code: 5622-5674
MD, Dr. Sci. (Med.)
Russian Federation, Saint PetersburgTatyana G. Tral
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: ttg.tral@yandex.ru
ORCID iD: 0000-0001-8948-4811
SPIN-code: 1244-9631
Scopus Author ID: 37666260400
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgGulrukhsor Kh. Tolibova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
Email: gulyatolibova@yandex.ru
ORCID iD: 0000-0002-6216-6220
SPIN-code: 7544-4825
Scopus Author ID: 23111355700
ResearcherId: Y-6671-2018
MD, Dr. Sci. (Med.)
Russian Federation, Saint PetersburgLyudmila K. Sotnikova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: sotnikova1996@yandex.ru
Russian Federation, Saint Petersburg
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