Clinical features of labor and morphological aspects of the myometrium receptor profile in obese women

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Abstract

BACKGROUND: Obesity is currently considered as one of the most significant social chronic diseases. It has been proven that obese pregnant women are more likely than women with normal body weight to experience complications of pregnancy and labor. The most frequent complications of labor in obese women are weakness and discoordination, which are probably associated with a decrease in the sensitivity of the myometrium to oxytocin, due to suppression of oxytocin receptor expression.

AIM: The aim of this study was to explore the clinical features of labor and morphological aspects of the myometrium receptor apparatus in obese women.

MATERIALS AND METHODS: We performed a prospective assessment of labor activity in women with obesity, with a combination of obesity and gestational diabetes mellitus and in healthy women. We also conducted a morphological study of myometrium biopsies obtained during cesarean section.

RESULTS: Obese patients are more likely to experience various complications of pregnancy and labor, which is the reason for the higher frequency of operative delivery. Patients with obesity showed lower expression of oxytocin receptors in the lower segment of the uterus, which, apparently, is the cause of abnormal contractility of the myometrium during labor and the lack of effect from drug correction of this condition.

CONCLUSIONS: The presence of obesity in women before pregnancy contributes to frequent complications of pregnancy and labor, abnormal uterine contractility related to the decreased oxytocin receptor expression, and a high incidence of surgical delivery.

 

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About the authors

Darya S. Seryogina

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott

Author for correspondence.
Email: d.sereogina2010@yandex.ru
ORCID iD: 0000-0002-6496-586X
SPIN-code: 2852-3281

MD

Russian Federation, Saint Petersburg

Elena V. Mozgovaya

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State University

Email: elmozg@mail.ru
ORCID iD: 0000-0002-6460-6816
SPIN-code: 5622-5674

MD, Dr. Sci. (Med.)

Russian Federation, Saint Petersburg

Tatyana G. Tral

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University

Email: ttg.tral@yandex.ru
ORCID iD: 0000-0001-8948-4811
SPIN-code: 1244-9631
Scopus Author ID: 37666260400

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Gulrukhsor Kh. Tolibova

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov

Email: gulyatolibova@yandex.ru
ORCID iD: 0000-0002-6216-6220
SPIN-code: 7544-4825
Scopus Author ID: 23111355700
ResearcherId: Y-6671-2018

MD, Dr. Sci. (Med.)

Russian Federation, Saint Petersburg

Lyudmila K. Sotnikova

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott

Email: sotnikova1996@yandex.ru
Russian Federation, Saint Petersburg

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Supplementary files

Supplementary Files
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2. Fig. 1. Indications for surgical delivery in the main group. PRM: premature rupture of membranes; PE: preeclampsia

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3. Fig. 2. Indications for surgical delivery in the comparison group

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4. Fig. 3. Indications for surgical delivery in the control group

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5. Fig. 4. Functional hypertrophy of the myometrium of the uterine lower segment. Staining with hematoxylin and eosin. ×200

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6. Fig. 5. Vascularization of the hypertrophied myometrium of the uterine lower segment. Staining with hematoxylin and eosin. ×200

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7. Fig. 6. Intermuscular hemorrhages in the myometrium of the uterine lower segment. Staining with hematoxylin and eosin. ×200

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8. Fig. 7. Expression of oxytocin receptors in the myometrium of patients in the main group (a), comparison group (b), and control group (c). Immunohistochemistry, ×400

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9. Fig. 8. Expression of progesterone receptors in the myometrium of patients in the main group (a) and control group (b). Immunohistochemistry, ×400

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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