Vol 62, No 1 (2013)

Articles
K 85-letiyu so dnya rozhdeniya akademika RAMN, zasluzhennogo deyatelya nauki RF, professora SAVEL'EVOY GALINY MIKhAYLOVNY
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Abstract
Journal of obstetrics and women's diseases. 2013;62(1):3-4
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To what classification of gestosis (preeclampsia) should adhere a doctor in daily work?
Savelyeva G.M., Krasnopolskiy V.I., Strizhakov A.N., Radzinskiy V.Y., Shalina R.I., Kurtser M.A.
Abstract
The present-day designation of gestosis as preeclampsia and eclampsia excludes the notion of “pre-eclampsia” as a period immediately preceding the attack of eclampsia what leads to the untimely and inadequate therapy. The authors suggest in the everyday work of obstetricians to use terminology that includes gestosis of various degree, pre-eclampsia and eclampsia.
Journal of obstetrics and women's diseases. 2013;62(1):5-9
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Demographic situation and development of perinatal psychology in Russia today
Ailamazyan E.K., Dobryakov I.V.
Abstract
The problem of low birth rates requires a complex solution. The actions that taken now in Russia, directed to one side: the material stimulation to increase birth rate and improving obstetric and gynecological care. The untapped resource is the development of perinatal psychology, organization perinatal psychological and psychotherapeutic assistance available to the population.
Journal of obstetrics and women's diseases. 2013;62(1):10-15
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EFFICACY OF GONADOTROPIN-RELEASING HORMONE AGONISTS TREATMENT OF THE SIMPLE ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE WITH OBESITY
Artymuk N.V., Shakirova Y.A.
Abstract
A prospective, randomized, open, comparative study. There were 105 women of reproductive age with obesity and simple endometrial hyperplasia without atypia (EH) included into the study. 13 patients had left the study.31 patients took an agonist of gonadotropin-releasing hormone (aGnRH) Buserelin at the dose of 3.75 mg intramuscularly every 28 days. 33 patients took 10 mg of norethisteron per day. 28 patients took combined estrogen-gestagen drugs (30 mkg of ethinylestradiol + 150 mkg of desogestrel). The base therapy of obesity (a balanced diet and a physical activity)had been administered to all of the patients. Treatment in all groups lasted 6 months. The results of this study showed that usage of aGnRH in management of endometrial hyperplasia in patients of reproductive age with obesity is most effective and safe.
Journal of obstetrics and women's diseases. 2013;62(1):16-21
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The tocography variants of uterine activity hyperstimulation
Voskresenskiy S.L., Tesakova M.L., Shilkina Y.V.
Abstract
We performed an analysis of 85 histories of labor. Depending on perinatal outcome and application of uterotonics all stories of labor were divided into 3 groups. We present typical signs and shapes of uterine activity hyperstimulation in the application of uterotonic in labor. We established that with the appearance of any signs of hyperstimulation, it is necessary to limit or suspend the infusion of drug or to revise the plan of labor conduction in favor of the Cesarean section.
Journal of obstetrics and women's diseases. 2013;62(1):23-31
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CURRENT STATE OF THE PROBLEM OF THE LABORATORY DIAGNOSTICS OF UROGENITAL TRICHOMONIASIS
Grigoryev A.N.
Abstract
The laboratory diagnostics of urogenital trichomoniasis is an actual problem of modern microbiology of infections of the reproductive tract. In the review, literature data on methods of microbiological diagnostics of trichomoniasis are presented, which include microscopy of wet mount and stained preparations, culture techniques, immunological methods and nucleic acid amplification tests.
Journal of obstetrics and women's diseases. 2013;62(1):32-41
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ROLE OF MYOMECTOMY IN INFERTILITY TREATMENT
Dolinskiy A.K.
Abstract
The Up to now, the role of uterine fibroids in the genesis of infertility and IVF failures is the subject of debate.Analysis of literature demonstrated that surgical strategy in patients with uterine myoma and infertility should be individualized. Along with the classic indications for myomectomy in women with infertility there are additional indications:
Journal of obstetrics and women's diseases. 2013;62(1):42-47
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Perinatal outcomes after ART with transfer of cryopreserved embryos
Kravchuk Y.N., Kalugina A.S.
Abstract
The number of children born after ART, which includes cryopreservation methods, is steadily rising worldwide. Data on perinatal outcomes after transfer of cryopreserved embryos is presented in the article. Analysis of the influence of fertilization method — IVF/ICSI, embryo cryopreservation method — slow freezing method and vitrification is composed.
Journal of obstetrics and women's diseases. 2013;62(1):48-54
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Diagnosis and a choice of tactics of patients with Dysplastic changes squamous epithelium of the cervix
Protasova A.E., Bezhenar V.F., Tsypurdeeva A.A., Antonova A.L., Dzyubiy T.I.
Abstract
The paper considers modern approaches to the study of the method of cytological changes of Dysplastic squamous epithelium of the cervix, definition of pathogenetic treatment with the aim of preventing invasive cervical cancer: reducing morbidity and mortality
Journal of obstetrics and women's diseases. 2013;62(1):55-63
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Combined therapy of extensive genital endometriosis with aromatase inhibitors
Yarmolinskaya M.I., Molotkov A.S., Durnova A.O., Polyakova V.O., Kvetnoy I.M., Bezhenar V.F.
Abstract
The article represents our experience in evaluation of aromatase activity in endometriotic lesions. We revealed that the most important parameter in evaluating aromatase activity is the area of its expression. Increased activity of this enzyme in the foci of endometriosis was identified, which proved the prescription of aromatase inhibitors in postoperative period for 68 patients of reproductive age with genital endometriosis. It was shown that the combined therapy of endometriosis-aromatase inhibitors and progestagens (19-nortestosterone derivatives) is effective, safe and well tolerated way of treatment of the disease, but, undoubtedly, this scheme requires further research
Journal of obstetrics and women's diseases. 2013;62(1):64-70
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Endometriosis as systemic genetic problem
Baranov V.S.
Abstract
Current data contributing to the origin and development of endometriosis (E) — sever common disease of reproductive age women are reviewed. Numerous theories and hypothesis as well as basic pathological mechanisms underlying E are briefly outlined. Whole gene-net and particular groups of candidate genes involved in E are presented. The later include genes of detoxification system, sex hormones and their receptors, cytokines gene, onco- suppressors the genes contributing to embryonic development of female reproductive organs and cell proliferation Major molecular genetic data imply epigenetic impact in the origin of disease which results from progressive disregulation of endometrium genome functions provoked by unfavorable combinations of candidate genes of some signaling pathways and defects in their expression due to abnormal methylation pattern. Histone modifications and the faults of miRNA content. In line with systemic genetic concept initial stages of E could be provoked by different genetic, epigenetic and even external factors which outcome is the same pathophysiological and pathomorphological damages clinically classified as E. Two feasible molecular genetic routs of E. are suggested. Both are relying on unscheduled expression of early embryonic genes such as WNT4, HOX10, HOX11, GALT provoking the changes in genetic program of endometriotic cells (metaplasia) and their subsequent progression as the lesions of ectopic endometrium
Journal of obstetrics and women's diseases. 2013;62(1):71-78
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Modern aspects of pregnancy planning in women with diabetes
Grigoryan O.R., Andreyeva Y.N.
Abstract
Pregnancy is a complex metabolic state, which includes dramatic changes in hormone secretion, amid growing demand for energy-rich compounds necessary for growth and development of the fetus. Women with diagnosed diabetes is always a greater risk of obstetric complications, which can be prevented by knowing the risk factors for diabetes, the criteria for early diagnosis, an algorithm of pregnancy, careful management of the postpartum period.
Journal of obstetrics and women's diseases. 2013;62(1):79-89
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The modern approach to the problem of adhesive disease in women of reproductive age
Shatova Y.S.
Abstract
Whatever reasons of adhesions are, ones are a major cause of pelvic pain, infertility and ovarian failure. Though the researches of the pathophysiological mechanisms of growth of adhesions are going on the attempts to determine effective methods to prevent adhesions do not rule to expected results. Advances in molecular biology identify number of biologically active molecules that regulate the inflammatory response, angiogenesis and tissue reconstruction. Those are crucial for normal peritoneal wound healing or for growth of tissue fibrosis.
Journal of obstetrics and women's diseases. 2013;62(1):90-101
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