The oxygen-induced retinopathy as an experimental model of retinopathy of prematurity

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Abstract

The experimental model of retinopathy of prematurity was developed on the base of an oxygen-induced retinopathy in newborn. Wistar rats. This model was meant to investigate histopathological and functional manifestations of the disease. The study was performed on 60 newborn Wistar rats. The main experimental group included 34 animals with induced retinopathy of prematurity, the control group — 26 experimental animals. The predominating morphological manifestations of the oxygen-induced retinopathy were photoreceptor apoptosis, and the development of pathological intraretinal vascularization. Histological and electrophysiological changes were also detected even before the formation of clinical signs of retinopathy. There was a significant impairment of immature retina architectonic after induced hyperoxia.

About the authors

Olga Aleksandrovna Konikova

St-Petersburg State Pediatric Medical University

Email: olgakonikova@gmail.com
department of ophthalmology

Vladimir Vsevolodovich Brzheskiy

St-Petersburg State Pediatric Medical University

Email: vvbrzh@yandex.ru
head of department of ophthalmology

Yelena Pavlovna Fedotova

St-Petersburg State Pediatric Medical University

Email: kris6060@mail.ru
department of ophthalmology

Ruslan Abdulayevich Nasyrov

St-Petersburg State Pediatric Medical University

head of department of pathological anatomy

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Copyright (c) 2013 Konikova O.A., Brzheskiy V.V., Fedotova Y.P., Nasyrov R.A.

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