Otsenka gipotenzivnogo effekta preparata «GLAUMAKS»

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Abstract

When choosing a medication, a physician has to be sure of its efficacy and safety for the patient. Carrying out of multiple post-clinical studies of different aspects of medication use is intended to help clinicians to correctly appreciate the capacities of proposed medications. The objective of this study is to evaluate the pressure-lowering effect of latanoprost 0.005 % - “Glaumax” according to the data of different tonometry methods at different baseline IOP levels and to compare the IOP-lowering effects of timolol 0.5 % and Glaumax. The pressure lowering effect in the Glaumax group significantly exceeds that of the timolol 0.5 % group regardless of IOP measurement method, at comparable baseline IOP level. In the group with higher baseline IOP level, the IOP decrease in % from baseline was higher. Mean IOP-lowering effect for Glaumax in the present study is comparable to the data of multicenter studies and meta-analyses carried out for the original “Xalatan” medication.

About the authors

Yury Sergeevich Astakhov

I. P. Pavlov State Medical University

Email: astakhov73@mail.ru
MD, doctor of medical science, professor, head of the department. Department of Ophthalmology

Vitaly Olegovich Sokolov

Diagnostic center N 7 (ophthalmological) for adults and children

Email: tavvos50@rambler.ru
candidate of medical science, ophthalmologist, head of the center

Natalia Vladimirovna Morozova

Diagnostic center N 7 (ophthalmological) for adults and children

Email: morozova_dc@mail.ru
candidate of medical science, deputy head of the center

Denis Pavlovich Novikov

Diagnostic center N 7 (ophthalmological) for adults and children

ophthalmologist

References

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  2. Егоров Е. А., Астахов Ю. С., Щуко А. Г. Национальное руководство по глаукоме.
  3. Егоров Е. А. Латанопрост (Ксалатан) в лечении глаукомы.
  4. Шмырева В. Ф., Петров С. Ю., Антонов А. А., Данилов С. С. Исследование суточных колебаний офтальмотонуса у пациентов с первичной открытоугольной глаукомой при монотерапии тимололом, латанопростом и травопростом.
  5. Camras C., Alm A., Watson P. Glaucoma treatment for 1 year with latanoprost, a prostaglandin analog, in the USA, Scandinavia and UK. American Academy of Ophthalmology, Annual Meeting: Atlanta. — 1995. — P. 89.
  6. Sihota R., Saxena R., Agarwal H. C., Pandey R. M., Gulati V. Peak pressures: crossover study of timolol and latanoprost // Eur. J. Ophthalmol. — 2003. — Vol. 13 (6).
  7. Watson P., Stjernschantz J. The latanoprost Study Group in United Kingdom: A six month randomized, double-masked study comparing latanoprost to timolol in open angle glaucoma and ocular hypertension. Ophthalmology. — 1995. — Vol. 103. — P. 126–137.

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Copyright (c) 2013 Astakhov Y.S., Sokolov V.O., Morozova N.V., Novikov D.P.

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