ERG assessment of the functional activity of the retina in following the surgical closure of idiopathic macular holes

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Abstract

Twenty patients with stage 3 or 4 idiopathic macular holes were evaluated with standard cone ERG, photopic flicker ERG at 8,3-30-Hz, to study the function of cone photoreceptors, bipolar cells, and Muller cells after the surgical correction of their macular hole. The correlations between the ERG parameters and the microperimetry and optical coherent tomography data were evaluated. IMH has been associated with the general reduction in the function of the cone photoreceptors and bipolar cells and with the sharp increase in the activity of Muller cells and their functional relationships with some bipolar cells. The nature of the changes in photopic standard and flicker ERGs demonstrated the dependence of the central retinal function on the dynamics of cone bipolar cells’ recovery. In the early period after the surgery of IMH, a sharp reduction in the flicker ERG at 24 Hz was found, to be followed by a progressive increase, which indicated a pronounced reduction in the bipolar cell function with the formation of the IMH and its substantial decrease after the vitreoretinal surgery. A significant increase in the glial index for flicker ERG at 24 Hz may be associated with a compensatory overreaction of retinal Muller cells in the preoperative and in the recovery period after the closure of IMH.

About the authors

Vladimir Vladimirovich Neroev

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: info@igb.ru
MD, professor, doctor of medical science, head of Moscow Helmholtz Research Institute

Marina Vladimirovna Zueva

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: visionlab@yandex.ru
professor, doctor of biological science, head of S. V. Kravkov Laboratory of clinical physiology of vision

Pavel Alexandrovich Bichkov

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: dr.bichkov@mail.ru
MD, ophthalmologist of retina pathology department

Irina Vladimirovna Tsapenko

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: sunvision@mail.ru
candidate of biological science, Senior Researcher of S. V. Kravkov Laboratory of clinical physiology of vision

Ol'ga Ivanovna Sarygina

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: info@igb.ru
MD, candidate of medical science, Leading Researcher and head of clinic in retina pathology department

Pavel Andreevich Ilyukhin

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: info@igb.ru
MD, candidate of medical science, research associate of retina pathology department.

Natalija Alekseevna Semenova

Federal State Budgetary Institution “Moscow Helmholtz Research Institute of Eye Diseases” of the Ministry of Healthcare of Russian Federation

Email: info@igb.ru
research assistant of S.V. Kravkov Laboratory of clinical physiology of vision

References

  1. Алпатов С. А., Щуко А. Г., Малышев В. В. Патогенез и лечение идиопатических макулярных разрывов. - Новосибирск: Наука, 2005. - 136 с.
  2. Зуева М. В., Нероев В. В., Цапенко И. В. и др. Топографическая диагностика нарушений ретинальной функции при регматогенной отслойке сетчатки методом ритмичекой ЭРГ широкого спектра частот // Рос. офтальм. журнал. - 2008. - № 2. - С. 18-22.
  3. Зуева М. В., Цапенко И. В. Структурно-функциональная организация клеток Мюллера: роль в развитии и патологии сетчатки /Клиническая физиология зрения. п/ред. Шамшиновой А. М. - МБН: М., - 2006. - С. 144-205.
  4. Нероев В. В., Зуева М. В., Бычков П. А., Цапенко И. В., Сарыгина О. И., Илюхин П. А., Семенова Н. А. Мультифокальная электроретинография при успешном хирургическом лечении идиопатических макулярных разрывов // Российский офтальмологический журнал. - 2014. - № 1. - (в печати).
  5. Чарльз С., Калькада Х., Вуд Б., под ред. Самойлова А. Н. Микрохирургия стекловидного тела и сетчатки. - М.: МЕДпресс-информ, 2012. - 400 с.
  6. Brooks H. L. Jr. Macular hole surgery with and without internal limiting membrane peeling // Ophthalmology. - 2000. - Vol. 107, N 10. - P. 1939-1948.
  7. Gass J. D. M. Idiopathic macular hole. It’s early stages and pathogenesis // Arch. Ophthalmol. - 1988. - Vol. 106, N 5. - P. 629-639.
  8. Gass J. D. M. Reappraisal of biomicroscopic classification of stages of development of a macular hole // Am. J. Ophthalmol. - 1995. - Vol. 119, N 6. - P. 752-759.
  9. Johnson R. N., Gass J. D. M. Idiopathic macular holes. Observations, stages of formation, and implications for surgical intervention. Ophthalmology. - 1995. - Vol. 95, N 7. - P. 917-924.
  10. Kokame G. T. Ultrastructural features of tissue removed during idiopathic macular hole surgery // Amer. J. Ophthalmol. - 1997. - Vol. 123. - P. 425-426.
  11. Kondo M., Sieving P. A. Primate photopic sine-wave flicker ERG: vector modeling analysis of component origins using glutamate analogs // Invest. Ophthalmol. Vis. Sci. - 2001. - Vol. 42, N1. - P. - 305-312.
  12. Marmor M. F., Fulton A. B., Holder G. E. et al. ISCEV Standard for full-field clinical electroretinography (2008 update) // Doc. Ophthalmol. - 2009. - Vol. 118, N 1. - P. 69-77.
  13. Peyman G. A., Cheema R., Conway M. D., Fang T. Triamcinolone acetonide as an aid to visualization of the vitreous and the posterior hyaloid during pars plana vitrectomy // Retina. - 2000. - Vol. 20. - P 554-555.
  14. Scott I. U., Moraczewski A. L., Smiddy W. E., Flynn H. W. Jr. et al. Long-term anatomic and visual acuity outcomes after initial anatomic success with macular hole surgery // Am. J. Ophthalmol. - 2003. - Vol. 135, N 5. - P. 633-640.
  15. Shah G. K., Rosenblatt B. J., Blinder K. J. et al. Triamcinolone-assisted internal limiting membrane peeling // Retina. - 2005. Vol. 26. - P. 972-975.
  16. Sugita S., Miyake Y. The focal macular electroretinogram in idiopathic macular hole [in Japanese] // J. Jpn. Ophthalmol. Soc. - 1994. - Vol. 98. - P. 609-615.
  17. Terasaki H., Miyake Y., Nomura R. et al. Focal Macular ERGs in eyes after removal of macular ILM during macular hole surgery // Invest. Ophthalmol. Vis. Sci. - 2001. - Vol. 42, N 1. - P. 229-234.
  18. Tewari A., Almony A., Shah G. K. Macular hole closure with triamcinolone-assisted internal limiting membrane peeling // Retina. - 2008. - Vol. 28. - P. 1276-1279.
  19. Yooh H. S., Brooks H. L. Jr., Capone A. Jr. et al. Ultrastructural features of tissue removed during idiopathic macular hole surgery // Amer. J. Ophthalmol. - 1996. - Vol. 122, N 1. - P. 67-75.
  20. Zueva M., Neroev V., Tsapenko I., Bychkov P., Sarygina O. Functional activity of retinal neurons and Muller cells in idiopathic full-thickness macular holes//Acta Ophthalmologica. - 2012. - Vol. - 90, Special Issue “EVER 2012 Abstract book”. - P. 266.
  21. Zueva M., Tsapenko I., Pak N., Vaskov S. What does the flicker ERG reflect in rabbit retina? // Symposium of ISCEV, 42nd: Abstracts. - Puerto-Rico, 2004. - P. 54.

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Copyright (c) 2013 Neroev V.V., Zueva M.V., Bichkov P.A., Tsapenko I.V., Sarygina O.I., Ilyukhin P.A., Semenova N.A.

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