Vol 19, No 4 (2011)

Articles
Comparative histochemical characteristic of different parts of cerebral cortex in rats after irradiation
Ilicheva V.N.
Abstract
The activity of energetic metabolism enzymes was studied in neocortex, archicortx and paleocortex of male-rats in experiment after their irradiation in a doze of 1,0 Gy. The comparison of histochemical indicators in the studied parts of brain has been carried out.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):8-12
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Great scientist and the genius of medical sciences: the 130-anniver-sary of the death of N.I. Pirogov
Mnikhovich M.V., Kaktursky L.V., Huminski Y.I., Fominа L.V., Vernigorodsky S.V., Kaminska N.A., Miglyas V.G.
Abstract
In an article on the 130th anniversary of the death of N.I. Pirogov, analysis of works N.I. Pirogov, which formed the foundation for the development of the modern fields of medicine. Works N.I. Pirogov covered a broad range of issues critical surgery, clinical, theoretical and experimental medicine, anatomy, general pathology, pathological anatomy, such as clinical and biological analysis of inflammation, abscesses, bone disease, infectious diseases and their control. Much attention N.I. Pirogov gave experimental studies on the development of collateral circulation, pathology of wound healing, shock, on plastic surgery. N.I. Pirogov – the creator of topographic (surgical) anatomy, pathology, policy makers, scientist, thinker and teacher.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):13-27
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Gene pharmacotherapy Inoperable patients with chronic lower limb ischemia
Shvalb P.G., Kalinin R.E., Deev R.V., Gryaznov S.V., Mzhavanadze N.D., Kiselev S.L., Isaev A.A.
Abstract
The article presents the results of the comparative six-month surveillance inoperable patients with atherosclerosis of lower extremities with clinical manifestations in the form of intermittent claudication (IIa-III century. AVPokrovskii to Fontaine), which are composed of conservative therapy received the drug genterapevtichesky "Neovaskulgen", a plasmid with the gene structure of vascular endothelial growth factor. The study included 50 patients (35 – in the clinical group and 15 – in the control group). The drug was administered intramuscularly, as close as possible to areas of ischemia, twice, at doses of 1.2 mg, with an interval of 14 days. Patients kontralirovlai: the length of pain-free walking distance, ankle-brachial index, transcutaneous oxygen napryazhdenie determined, the linear velocity of blood flow in the affected segment. It is established that in the clinical group were significantly increasing the length of pain-free walking distance, the linear velocity krovtoka. To a lesser extent the other indicators are growing. In the control group had deterioration of patients. The obtained results show the effectiveness of the drug "Neovaskulgen."
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):28-37
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Pharmacokinetic of simvastatin at experimental hypothyreosis
Yakusheva E.N., Popova N.M.
Abstract
In article data of the research devoted to studying of pharmacokinetic of simvastatin at experimental hypothyreosis are resulted. It is shown changes of pharmacokinetic parameters of main metabolite of drug – β-hydroxyacid of simvastatin, which says about decrease of bioavailability and correlation of these changes with level of T4.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):38-42
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Physiological aspects of adaptation of cadets of academy FSIN of Russia to physical activities
Voronin R.M.
Abstract
In this article some aspects of adaptation to physical activities of cadets of Academy FSIN of Russia are considered. 98 cadets with high (48 cadets) and low (50 cadets) success of physical training have been surveyed. In order to analyze the heart rate variability a complex "Varicard" and ISKIM-6 software have been used. Results of research specify in distinctions of mechanisms of adaptation in groups.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):43-48
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Influence of the thyroxine on the functional activity of the р-glycoprotein in the experiment
Yakusheva E.N., Byryukova A.S., Shchulkin A.V., Nikiforova L.V.
Abstract
In the research on the rabbits influence of a L-thyroxine on the activity of the protein- transporter Р-glycoprotein (Pgp) was studied. Activity of the Pgp was investigated on the pharmacokinetics of its marker substrate fexofenadine. It was established that introduction of a L-thyroxine within 14 days lead to dose-dependent rising of Рgp activity.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):49-53
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Current issues in health organization care in the penal colonystrict mode
Medvedevа O.V., Ermolaeva T.V., Yusufov R.S.
Abstract
The paper presents an analysis of the activities of the medical service of penal colonies. The major issues of a complex therapeutic and preventive measures against prisoners with different levels of health.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):54-57
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Estimation doctors of material base of the departmental hospital
Laktionova L.V.
Abstract
The article presents the results of sociological survey of doctors in one of the FMBA hospitals of Russia concerning an estimation of its material and technical base (MTB) are resulted. Features of estimations MTB are revealed by doctors-heads and doctors-experts.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):58-60
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The comparative hygienic analysis of the vehicle density in Ryazan districts
Lyapkalo А.А., Dementiev А.А., Tsurgan А.М.
Abstract
The articles includes the results of observation of the vehicle density and a comparative analysis of the transport conditions on weekdays and at weekends in warm and cold seasons in Ryazan districts. The maximum traffic load was observed in the city centre and the minimum one was in Moscowsky district of Ryazan.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):61-66
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Functions and operation procedure of the distance advisory centers with visiting anesthesiology-reanimation brigades
Misyakov V.B., Konovalov O.E., Fomina A.V.
Abstract
In article the organization of work of the remote advisory centers with exit anesteziologo-reanimatsionnymi obstetric and neonatal brigades of the first help, organized in the Penza region on the basis of the Perinatal center is analyzed. Functional problems of the remote advisory centers are in detail considered. For transfer of women and newborns indications are presented to the center.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):67-70
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Organizational-functional model of monitoring of health and quality of life of employees of law-enforcement bodies
Pozdnjakova M.A., Danilov V.A., Tamojkin A.V., Jashkov A.A.
Abstract
In article approaches to construction of organizational-functional model of mediko-sociological monitoring of health and quality of life of employees of law-enforcement bodies are described. Separate modules of model, and also information sources about health and quality of life of the given contingent are in detail considered.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):71-73
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The health of children-orphans and children, In difficult life situations (based on materials Ryazan region)
Petrovа E.I.
Abstract
The paper presents an analysis of health status residing in institutions for orphans and children in difficult situations on the basis of clinical examination, which aims tomonitor the health status of effectiveness of therapeutic and corrective measures.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):74-77
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The complex analysis of a personnel maintenance of children's out-patient-polyclinic establishments of Ryazan
Chvireva N.V.
Abstract
In article the results of the analysis of a personnel potential on an example of children's out-patient-polyclinic establishments of Ryazan are resulted. The author had been studied the basic problems complicating activity of establishments of a primary link, and precisely – the provision by paediatricians, experts in the conditions of deficiency of financing under the given item of expenses, the dynamics of the quotient of pluralism, the level of a professional trainings of a medical personnel.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):78-81
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Peculiarities of ventilation disorders in the patients with inner organs pathology
Rakita D.R., Kuspanaliyeva D.S.
Abstract
Hyperventilation syndrome is a very acute problem of general medicine. It can be seen in patients with inner organs pathology. The aim of our investigation was to reveal the peculiarities of ventilation disorders in the patients with bronchial asthma, arterial hypertension and GIT pathology. 70 people were examined. It was established that patients with arterial hypertension were revealed ventilation disorders more often. These patients also had breathing pattern disorders.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):82-86
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Predictors of poor prognosis in chronic heart failure
Smirnova E.A.
Abstract
he estimation of prognosis and identification of mortality predictors in CHF patients are one of the important clinical goals. 4-year survival rate in 167 patients with verified CHF NYHA I-IV, revealed by screening of representative sample in Ryazan region, is 76,6%. The main factors impairing prognosis in population are age and functional class of CHF.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):87-92
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Influence of metabolic syndrome on the course of bronchial asthma
Sysoevа M.S., Solovievа A.V., Nikiforov A.А., Rakita D.R.
Abstract
To estimate how metabolic syndrome influences the course of bronchial asthma we investigated 46 patients, 35 of them were diagnosed with metabolic syndrome. We established that in the patients with association of asthma and metabolic syndrome respiratory function and asthma control were significantly lower than in patients without metabolic syndrome. Also we established the inverse relation between the degree of obesity, abdominal type of obesity, the degree of arterial hypertension, fasting glycemia, atherogenous disturbances and the presence of diabetes. Hypocapnic disturbances were also found 2 times more frequently in asthmatic patients having metabolic syndrome.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):93-98
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Evaluation of quality of life and correlation carbohydrate metabolism, hormonal spectrum of patients with diabetes type 2 primary hypothyroidism, complicated distal neuropathy
Dubininа I.I., Uryasev O.M., Karapysh T.V.
Abstract
The aim of the study was to study the dynamics of the quality of life, carbohydrate metabolism, hormonal spectrum, and their degree of correlation in patients with type 2 diabetes in combination with primary hypothyroidism complicated by distal neuropathy. We examined 62 patients with distal neuropathy. The study found that the fasting glucose level is high inverse correlation with the parameter self-assessment of mental health in patients with type 2 diabetes in combination with primary hypothyroidism. Compensation under the influence of hypothyroidism hormone replacement therapy improves quality of life of most patients with combined pathology: pain intensity, physical functioning, general health, vitality and self-assessment of mental health.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):99-103
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The role of antibodies to tireoperoksidaze when autoimmune orbitopathy
Lihvantseva V.G., Sviridenko N.Y., Rudenko E.А., Gontyurova O.А., Vygodin V.A.
Abstract
The authors studied the role of antibodies to tireoperoksidaze when autoimmune orbitopathy in patients with Graves disease. It is shown that the presence at the TPO from HIV-positive patients with autoimmune thyroid closely correlates with higher rank the severity and intensity (amplitude) autoimmune inflammation in orbit. Findings allowed authors to ascribe the AL to SLIP risk factors increase the severity and activity of autoimmune orbitopathy in patients with Graves disease.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):104-110
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Clinical condition and quality of life sick of a psoriasis, as criteria of efficiency phytoecdysteroides in complex therapy of a dermatosis
Terentyev S.J., Yermoshina N.P., Darmograj V.N.
Abstract
The analysis of influence of preparations phytoecdysteroides in complex treatment sick of a psoriasis on their clinical condition and quality of life is presented. Thus there is an expressed decrease in a psoriasis area and severity index and a dermatological index of a scale of symptoms, and also substantial increase of life quality of patients.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):111-115
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Immunological indices in patients with colorectal cancer during in-patient treatment
Semionkin E.I., Bublikov I.D.
Abstract
In the investigation immunological status assessment was made in patients with colorectal cancer of the III stage before and after operation. Cellular and humoral immunity was investigated, and psychovegetative status. We revealed immunosuppression in patients, they are in serious stress situation with prevalence of sympathetic regulation of peripheral nervous system.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):116-119
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The life quality of the patients who have sustained the partial gastrectomy concerning the peptic ulcer
Tarasenko S.V., Zaitsev O.V., Kopeykin A.A., Rahmaev T.S., Natalsky A.A., Bakonina I.V.
Abstract
A life quality comparative studying on scale SF-36 of three groups of patients is made: 1st – peptic ulcer disease patients (n=44), 2nd and 3rd – the respondents who have sustained, accordingly, a partial gastrectomy by Bilrot-I (n=75) and Bilrot-II (n=34). A life quality of the patients who have sustained a partial gastrectomy both on Bilrot-I, and on Bilrot-II, has appeared authentically above quality of a life of the patients, suffering a peptic ulcer. A life quality of the patients who have sustained a partial gastrectomy by Bilrot-I, on scales of physical functioning and the general health is authentic above quality of a life of the patients who have sustained a partial gastrectomy by Bilrot-II. Comparative studying of quality of a life of the respondents who have sustained a partial gastrectomy by Bilrot-I in tubular and classical variants has not taped authentic differences on one scale SF-36.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):120-124
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Economical effective and social significance of simultaneous correction in organs of the abdominal cavity and pelvic minor with obesity
Ivanov V.V.
Abstract
In the preformed research is studied the economical efficiency and social significance of simultaneous operative invasions in the surgery and gynecology. It is shown that the rational usage of miniinvasion technologies leads to the decreasing of the stationary hospital period of the patients the summary period of his disability here are also reduced the expenses per day of the patient's disability social insureness, the expenses for postoperative observations and narcosis. It is very actual for the treatment of the patients with different obesity degrees. By the way there are made the circumstances for more rational operating of the expensive high-technological equipment. All this facts play a bigger role under the circumstances of the reformation of the healthcare system.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):125-129
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Investigation of clinical effectiveness of fluorine-containing filling materials for treatment of secondary caries of permanent teeth
Gluhova E.A., Morozova S.I.
Abstract
There is comparative characteristic of effectiveness of use of fluorine-containing filling materials on the base of results of clinical investigation of treatment of tooth with secondary caries of 120 patient at the age of 18-55 years. There is found dependence of secondary caries from filling materials. There are good results of adaptation and safety of fillings afber fillings of carious cavities with fluorine containing materials. The least percent of complications in these groups is caused by containing of fluorides in its composition, which help in remineralization of hard dental tissues.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):130-134
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The results of the research of the action of the toothpastes «Lacalut Brilliant White» on the state of oral cavity of the adolescents after the orthodontic treatment
Tabolina E.S., Landinova V.D., Morozova S.I., Ogneva A.N., El Uazzani M.
Abstract
In the article represents the results of clinical research of the toothpastes «Lacalut Brilliant White» applied by the adolescents after the orthodontic treatment with the use inremovable orthodontic equipment. It’s detected the reduction of the inflammatory phenomenons of the gingival tissues, and also improvement of the hygienic state of the oral cavity by the use of the toothpastes «Lacalut Brilliant White».
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):135-140
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Method for the quantative determination of β-hydroxysimvastatin in blood plasma
Popova N.M.
Abstract
Article is devoted working out of an original HPLC method of quantitative determination of β-hydroxysimvastatin in the blood plasma. In work the HPLC system "Stayer" with the spektro-photometric detector was used. Analysis was achieved on the reversed phase column «Beckman Coulter». Separation of β-hydroxysimvastatin from the blood plasma carried out a method liquid Extraction
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):141-146
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Environmental factors and healthstatus of population
Berestenko E.D., Grigoriev Y.I.
Abstract
The article provides an overview of publications on the influence of environmental factors on health status of population.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):147-153
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Modern views on the relationship of the upper and lower respiratory tract in allergic rhinitis and asthma
Gusсhin M.Y., Barkhina T.G., Golovanova V.E., Polner S.A.
Abstract
Research presented in a modern perspective on the problem of cellular-humoral and immunological interactions of the upper and lower airways in allergic rhinitis and bronchial asthma. The mechanisms of hyper-nasal mucous membranes and bronchial tubes in the tissue, cellular and subcellular levels. The correlation between damage to the epithelial and stromal cells and early debut of the disease and the severity of the pathological process.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):154-160
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Peculiarities of regression of limb ischemia after ligation operation in drug-addicted patients with post-injection pseudoaneurysms of peripheral arteries in the long-term period
Karpov V.V., Shvalb A.P., Gryaznov S.V.
Abstract
We performed a comprehensive analysis of the state of limb circulation after the extended ligation of main arteries of iliofemoral segment in drug-addicted patients with post-injection pseudoaneurysms in the long-term period (1-3 years). We used both clinical and instrumental methods. We observed that 92% of patients with limb salvage in the short-term period show stable regression of ischemia in the long-term period.
I.P. Pavlov Russian Medical Biological Herald. 2011;19(4):161-166
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