Vol 17, No 1 (2009)

Articles
THE CLASTER ANALYSIS, AS A METHOD OF AN ESTIMATION OF THE INFLUENCE OF PERSONAL TYPOLOGICAL CHARACTERISTICS ON SUCCESS OF A PERSONAL ACTIVITY*
Lapkin M.M., Karasev R.P., Trutneva E.A., Grigorenko T.M.
Abstract

The expediency of use of methods of multivariate statistics, in particular of the claster analysis, for revealing of the individual personal properties influence of the person nervous system on productivity of his purposeful activity is proved.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):141-147
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THE TREATMENT OF THE CHRONIC INFLAMMATORY DISEASES OF INTESTINE WITH THE USE OF IMMUNOSUPRESSANT BIOLOGICAL DRUGS
Schwarz V.J., Nogaller A.M.
Abstract

Prevalence, gravity of current, complexity of treatment of chronic inflammatory diseases of intestine - the illnesses of Crone and the ulcer of colitis - cause the value of this problem in modern gastroenterology. Despite of intensive researches, its pathogenesis remains not clear. It influences develop owing the combination of many negative factors at the leading part of the during the treatment of genetic factors and the factors of an environment.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):147-156
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THE LITTLE-KNOWN FACTS FROM A LIFE OF THE I. P. PAVLOV
Zagrina N.A.
Abstract

In work the little-known facts from a life of academician I.P.Pavlov are discovered.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):156-159
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Biochemistry, physiology, biophysics, pathological physiology
OCCURRENCE DISCRETE TYPES OF CONSTITUTION IN GENETICALLY UNTIED POPULATIONS LIVING IN NORTHERN REGION
Molchanova T.N., Ragozina O.V.
Abstract

 The purpose of research - a comparative estimation of populations radical and outside the population on frequency of occurrence discrete types of constitution. It is revealed, that under influence of factors of the North authentic deviations in distribution somatothypes, and with expressed sexual dimorphism, not only at natives of the North, but also migrants the second, third generations are observed. Authentically higher percent of occurrence of lefthanders among aboriginals is found out. At men occurrence lefthanders, than among women authentically is higher. At aboriginals of the North more often occurrence evening chronotypes is observed. At women the rhythmic organization is expressed more precisely, in comparison with men.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):18-26
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THE INFLUENCE OF AN ULTRADISPERSE POWDER OF COBALT ON BIOLOGICAL ACTIVITY OF POLYSACCHARIDES OF THE POLYGONUM AVICULARE
Churilov G.I., Ivanycheva Y.N., Polyshyk S.D.
Abstract

The article presents the results of pharmaceutical activity of polysaccharide complex investigation, got out of the Polygonum aviculare, the seeds of which were influenced by ultradisperse powder of cobalt before planting.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):26-33
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Morphology and pathological anatomy
MORFOLOGICAL CHARACTERISTIC OF IMMUNE SYSTEM OF BALB/C MICE AFTER CORRECTION MICROFLORA DISTURBANCES BY «ENTEROCINE» AND «COLIBACTERINE» PROBIOTICS
Ovcharova A.N., Mikhailova L.p., Serebryakov S.N., Makarova O.V., Kozlovsky Y.E., Matevosyan K.S., Tikhonova N.B.
Abstract

Normalization of intestinal microflora disturbances by probiotics «Enterocine» and «Colibacterine» treatment has been revealed after experimental dysbiotical condition, induced by antibiotics. The «Enterocine» is much more effective then «Colibacterine», because of higher content of E.coli and increasing number of Enterococci in intestinal microflora of «Enterocine» treated mice. Both probiotics lead to normalization of thymus and spleen morphology and function.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):8-18
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Microbiology, immunology, infectious diseases
CLINICO-MORPHOLOGICAL AND ETHIOLOGICAL STRUCTURE OF NOZOCOMIAL INFECTIONS AT PATIENTS IN THE DEPARTMENT OF REANIMATION AND INTENSIVE THERAPY
Vorobjeva O.N., Kamaleeva M.F., Zhilina N.M., Chechenin G.I., Chelpanova L.I.
Abstract

During the period 2006-2007 there were allocated and analysed 457 clinical shtamms of activators of heavy nozocomial infections. The leaders of pathogens at various forms of intrahospital complications are the specimens of gramm negative microflorae - Acinetobacterses spp. (16,63 %) and Pseudomonas aeruginosa (14,44 %), the enterococcus were allocated in 13,35 % of cases, the clebsiels – in 11,6 %, the intestinal stick and coagulazo-positive staphylococcus were met practically with identical frequency (9,63 % and 8,75 % accordingly). It is necessary to note enough the high densities of mushrooms of sort Candida (6,35 %). It was noted the statistically significant prevalence of microbic associations among the bacteria grammpositive and grammnegative, the hospital infectious process was confirmed. The seasonal prevalence of shtamms allocation is analysed: the peak of purulent – septic complications in ОRIT is in years months - June (17,3 %) and August (10,0 %), and also for April and October (9,8 % and 9,5 % accordingly); the minimal diseases is registered in winter months. It is more often the nozocomial infection among the young men and women of the most efficient age (20-45 years).

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):33-39
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THE ACTIVITIES OF CELLULAR AND HUMORAL IMMUNITY IN THE PATIENTS WITH PEPTIC ULCER, ASSOCIATED WITH HELICOBACTER PYLORI
Stepchenko A.A.
Abstract

The article are presented results study of some immunological activities in the patients with peptic ulcer associated with different culture of Helicobacter pylori. They are established the reduction of phagocytic activity of neutrofils and IgG, disbalances of subpopulation of T-lymphocytes (increasing CD4+ and decreasing CD8+) in blood of the patients with peptic ulcer associated with toxigenic culture of Helicobacter pylori. It is revealed the increasing of level of proinflammatory cytokines (TNFα, IL- 1β, IL-8 and INFγ) and antiinflammatory cytokines IL-4, IL-10, transformed growth factor β1 (TGF- β1) strongly pronounced at the patients with peptic ulcer associated with toxigenic culture of Helicobacter pylori.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):39-49
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Pharmacology, clinical pharmacology
THE CONTRASTIVE VALUATION OF ANGIOGENIC EFFICACY OF THE L-ARGININE AND VASCULAR ENDOTHELIAL GROWTH FACTOR FOR TENTATIVE LIMB ISCHEMIA
Artyushkova E.B., Pashkov D.V., Tsokolayeva Z.I., Pokrovskiy M.V., Pokrovskaya T.G., Artyushkova E.V.
Abstract

The tentative research was made in 24 rats, Wistar line. The microcirculation level was evaluated in Laser-Doppler flowmetry method and by immunohystochemical visualization of the vessels in the muscles. The chronic ischemia was modeling by cutting out of the femoral artery. The intramuscular introduction of VeGF and intraperitoneal introduction of L-arginine 200 mg/kg were used for treatment. The isotonic solution of NaCl was used in control group. The results were valued in 14-th day. The vessels number increased in groups treated by VeGF and L-arginine. It was statistical difference in microcirculation level between control group and group that was treated by L-arginine.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):46-52
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THE USE OF TAMOXIFEN IN THE TREATMENT OF DIFFUSE FORMS OF THE MASTOPATHY
Donskov A.K., Kulikov E.P., Chumachenko P.A.
Abstract

Indications on the application of tamoxifen during the treatment of the mastopathy have appeared in the literature in 70th years of the last century. These facts were considerably various concerning dozes, terms of application of a preparation. On the basis of experimental and clinical researches the conclusion about efficiency of an application of tamoxifen during the treatment of the diffuse forms of mastopathy was made.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):52-58
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EXPERIMENTAL BASIS OF CELL CARRIERS USING FOR DIRECTED TRANSPORT OF ANTIBIOTICS AND FLUOROQUINOLONE IN NON-OBSTRUCTIVE PYELONEPHRITIS
Lazarev A.I., Siplivyi G.V., Kukureka A.V., Siplivaya L.E.
Abstract

It was shown in investigations on rats that introduction of aminoglycoside antibiotics or fluoroquinolone, included into erythrocyte or leukocyte carriers in pyelonephritis, decreased amount of leukocyte accumulation centers in kidneys increased or normalized the level of enzymes in the organ, excretory function of kidneys, impaired immunometabolic parameters.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):58-63
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STUDY OF THE DOSE-DEPENDANT CARDIOPROTECTIVE EFFECTS OF MACROLIDES
Chernomortseva E.S., Pokrovskaya T.G., Artushkova E.B., Pokrovskiy M.V., Gureev V.V., Legkova Y.V.
Abstract

In laboratory animals is carried out a study of the dose-dependant cardioprotective effects of the group of modern macrolides with the simulation of the coronaroocclusional myocardial infarction. The preparations being investigated effectively decrease lethality and decrease the zone of the necrosis of left ventricle after coronaroocclusion. The dose-dependant effects are expressed in groups of 14- and 15- member macrolides.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):63-68
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Hygiene, ecology, epidemiology, healthcare organization, history of medicine
INFORMATIONAL-EDUCATIONAL WORK AMONG MENTAL PATIENTS’ RELATIVES AS A PART OF SOCIAL REHABILITATION
Petrov D.S., Konovalov O.E.
Abstract

In the article the questions of development of educational programs for mental patients’ families have been studied. We present the results of questioning of people, whose relatives have been admitted to Ryazan district clinical psychiatric hospital for inpatient treatment. The results obtained show the level of relatives’ awareness of treatment modes, techniques of prevention of exacerbations, and their role in the treatment process of the patient. The importance of estimation of awareness of mental patients’ relatives and working out of special psychoeducational programs for optimization and improvement of rehabilitation actions have been emphasized.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):68-73
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Internal medicine
THE INFLUENCE OF AFOBASOL ON THE PATIENTS LIFE QUALITY DURING THE SYSTEM PATHOLOGY
Agarkov N.M., Zhidkih B.D., Kolomiets I.V., Markelov M.J.
Abstract

85 patients (43 with a stomach ulcer of a duodenal gut and 42 with a syndrome of the angry intestines) are surveyed. At 20 of patients in everyone nosology to group to standard therapy it was in addition appointed afobazol in a doze of 30 mg day within 10 days of hospitalization. Quality of a life was compared by means of test SF-36. As a result of use parameters of test SF-36 have authentically increased in treatment afobazol at sick of a stomach ulcer on scales a pain, the general health, viability, social functioning, mental health, and at patients with a syndrome of the angry intestines – a pain, viability, mental health that testifies to positive influence of the given preparation on quality of a life. The rate of therapy afobazol within 10 days on a background of standard therapy allows to receive authentic improvement of quality of a life (a physical and psychological component) at gastroenterology patients at the most widespread nosology forms.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):73-80
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DEPRESSIONS, ANXIETY AND QUALITY OF LIFE AT PATIENTS WITH FIBRILLATION OF AURICLES
Evsina O.V., Jakushin S.S.
Abstract

In study anxiety and depression in 112 patients with different types of atrial fibrillation determined that 55,4 % patients have this condition, including 13,4 % mild and moderate depression (in aggregate with anxiety – 10,7%), subclinical depression – 15,2% (in aggregate with anxiety – 10,7%), anxiety – 26,8%. This condition dominates in patients with persistent atrial fibrillation, makes worse clinical history of the disease, leads to recurrence attack, reduces quality of life.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):80-88
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GASTROESOPHAGEAL REFLUX DISEASE AT RESIDENTS OF RYAZAN (ACCORDING TO EPIDEMIOLOGICAL RESEARCH)
Maslennikova E.V., Butov M.A.
Abstract

Research is lead within the limits of Multicentral investigation “Epidemiology of gastroesophageal reflux disease in Russia”. In questioning have taken part 1299 person. Attributes of gastroesophageal reflux disease (GERD) are revealed at 13 % respondents. Most often attributes of GERD meet among persons young and advanced age.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):88-93
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THE STUDY OF ACUTE CHRONIC HEART DISEASE PREVALENCE AND MORTALITY IN RYAZAN BY THE EXAMPLE OF ZHELEZNODOROZHNIY REGION
Nikulina N.N.
Abstract

The fatal and nonfatal cases of acute CHD were actively revealed among 81 841 population for 6 months by review of medical out-patient cards, hospital medical histories, ambulance reports, acts of civil status, autopsy reports and premortal symptoms. The specified cardiovascular mortality amounted 57.4% of adults (≥18years) mortality (vs statistical level of 61.1%, р>0.05). CHD as cause of death was not confirmed in 29.1% cases (р<0.01). As a result of detection of acute CHD induced out-ofhospital deaths the specified acute CHD death-rate exceeded the statistic level in 2.4 times (р<0.001) and out-of-hospital mortality mounted to 61.1% (statistic rate - 19.0%).

The study results revealed the overdiagnosis of CHD as cause of death with significant depreciation of acute CHD death-rate, especially in out-of-hospital death cases.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):93-99
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FREQUENCY AND STRUCTURE OF RHYTHM DISORDERS IN THE PATIENTS WITH ASTHMA, BASED ON THE DATA OF HALTER MONITORING
Uryasyev O.M., Varvarin V.M.
Abstract

Different types of rhythm and conduction disorders in the patients with persistent bronchial asthma. In Halter monitoring of electrocardiography in 96% of cases arrhythmias were revealed. Supraventricular and ventricular arrhythmias were predominant. Complex arrhythmias were revealed in 81% of patients.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):99-104
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Psychology, clinical psychology, neurology, psychiatry, narcology
THE APPLICATION OF THE ANTIGOMOTOXICAL PREPARATIONS IN THE REGENERATIVE TREATMENT OF VERTEBRONEUROLOGICAL PATIENTS AFTER INTERVERTEBRAL ECTHOMIE
Budanov A.A., Burshinov A.O.
Abstract

The paper the results of clinical and instrumental and multimodality treatment of 85 patients with radiculopathy and radiculomyeloishemic syndroms of lumbar osteochondrosis. Based on the data available in the literature and their own findings, the authors analyze the clinical sympatology. From the pathogenetic points of view, the outline spesific indications for new potentialities of medical treatment by homtopathic drugs.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):104-110
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NEUROPSYCHOPHYSIOLOGICAL FEATURES OF PATIENTS WITH DIFFERENT FORMS OF PARKINSON’S DISEASE
Starikov A.S., Butova V.M.
Abstract

An extent of alteration of motor unit potentials (MUP) in Parkinson’s disease directly depends on the form of the disease. In patients with the shaking-rigid form a decrease in duration of MUP is mostly observed and more common is increase in the amplitude of MUP. All patients with different forms of the disease equally regard their disease as a psychotraumatic factor that impairs their quality of life and restricts their role in the society.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):110-115
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Surgery
THE PROBLEMS OF REHABILITATION OF THE PATIENTS AFTER THE EXTREMITY AMPUTATION
Shvalb P.G., Baranov C.B.
Abstract

Quality of a life of patients with a chronic critical ischemia of the lower extremities and an ineffectual attempt of the restoration of a blood-groove before amputation, after amputation and at a stage of prosthetics with the help of own questionnaire with special specificity is analysed.

The indications to the amputation and reamputation the of the lower extremity are formulated.

It is shown, that the duly and correctly executed amputation without the general and local complications in the postoperative period though results to the disablement (invalidisation), but as it is paradoxical sounds, it improves some aspects of quality of a life of the patient. Therefore the amputation is one of regular, though also undesirable methods of treatment of patients in a stage of a critical ischemia.

The conclusion is made, that process of rehabilitation of patients in a stage of a critical ischemia with ineffectual attempt of restoration of a blood-groove after the extremity amputation depending on a way of movement proceeds during 2 periods.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):115-121
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Clinical and experimental oncology
EFFECTIVENESS OF THE SYSTEMATIC MEDIASTINAL BILATERAL LYMPH DISSECTION IN THE SURGICAL TREATMENT OF LUNG CARCINOMA
Tchernyh A.V.
Abstract

The systematic lymph dissection, a drastic treatment procedure in the surgical treatment of lung carcinoma, is declared to be an operative procedure helping to assess the true extent of a neoplastic [tumor] process. From the 300 operative interventions the 150 (50,0%) came to “expanded” operations which were followed by a systematic lymph dissection from principal considerations. The other 150 (50,0%) patients were operated typically without any systematic mediastinal lymph dissection. The general five-year probability of survival (equal to 30%), while the postoperative lethality is equal to 6,7%, speaks for a surgical assistance of a good quality in the clinical hospital. To present day 254 (85,0% from the 300) patients have been watched over.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):121-127
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EFFECTIVENESS OF BODY-SECTION RADIOGRAPHY IN DETERMINATION OF LYMPHOGENIC SPREAD OF RECTAL CANCER
Kolesnikova N.O., Khubezov D.A.
Abstract

For choice of optimal volume of resection in rectal cancer we need to clearly realize the degree of local tumor’s invasion (T-criteria), and also presence or absence of lymphogenous dissemination of tumor (N-criteria). MRI was done in 60 patients , suffered from rectal cancer. Use of MRI allows reliably to find the degree of lateral and lymphogenous dissemination of the process and to evaluate the optimal volume of resection. In evaluation of local tumor’s invasion (T-criteria) MRI had sensitivity 91.2 %, specificity 96.7 %, in metastases in lymphnodes evaluation (N-criteria) sensitivity 78.3 %, specificity 95 %.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):127-134
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Dentistry
INTERNAL IMAGE OF DISORDER IN PRACTICE OF STOMATOLOGIST: STUDY OF SPECIAL FEATURES AND ELUCIDATION OF PSYCHOLOGICAL CAUSES OF LOW DIAGNOSTIC EFFECTIVENESS
Shlykov M.V., Wagner V.D., Sirota N.A.
Abstract

On the bases of studying special attitude to stomatological disorder and its treatment the necessity of psychological correction of internal image of disorder of the majority of the patients who need stomatological rehabilitation is substantiated. It has been elucidated low effectiveness of diagnostic by stomatologist. It was shown that one of the factors of efficient express-diagnoses of internal image of disorder in stomatological practice is to raise stomatologists’ communicative competence to the proper level.

I.P. Pavlov Russian Medical Biological Herald. 2009;17(1):134-141
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