The role of androgenous deficiency in the development of urolitiasis in experimental ethylenglycol rat model

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract


In spite of high incidence of urolitiasis there is still no integral concept explaining all its causing factors and conditions as well as mechanisms of its development. Judging by the clinical observations one may suppose the androgenous deficiency might boost the formation of stones in the kidneys however there are no decisive proofs of androgenous deficiency role in concrement formation in kidney. These proofs may be yielded by means of a crude experimental model. 60 albino male rats were studied in “ethylenglycol” rat model reproducing urolithiasis for the assessment of androgenous deficiency effect on the development of this disease. “Ethyleneglycol” model of urolithiasis consisted of adding 1 % ethylene glycol solution to drinking water for 4 weeks. Androgenous deficiency was reproduced by castration. The experimental model has successfully produced urolithiasis with considerable disturbances in the structure and function of kidneys including microconcrement formation. Androgenous deficiency (castration) was shown to considerably boost the development of urolitiasis caused by ethylene glycol. In spite of similar morphological signs of urolitiasis in both experimental groups the androgenous deficiency caused by castration has been demonstrated to speed up and worsen the development of the disease. The microconcrements by the papilla of kidney in castrated rats with androgenous deficiency formed earlier and were multitudinous and larger in size than in experimental animals receiving 1 % ethylene glycol solution to drinking water for 4 weeks but without castration.

Full Text

Restricted Access

About the authors

Nair Sabirovich Tagirov

St. Petersburg City Hospital of St. Elisabeth

Email: ruslana73nair@mail.ru
MD, PhD, doctor. Urologiс Department

Alexander Petrovich Trashkov

St. Petersburg State Pediatric Medical University

Email: trashkov@gmail.com
MD, PhD, Associate Professor. Department of Pathophysiology and Immunopathology

Lev Dmitrievich Balashov

St. Petersburg State Pediatric Medical University

Email: levbalashov@mail.ru
MD, PhD, Associate Professor. Department of Pathophysiology and Immunopathology

Nikita Alexeevich Balashov

St. Petersburg State Pediatric Medical University

Email: levbalashov@mail.ru
six year student. Department of Pathophysiology and Immunopathology

References

  1. Васильев А. Г., Комяков Б. К., Тагиров Н. С., Мусаев С. А. Чрескожная нефролитотрипсия в лечении коралловидного нефролитиаза. Профилактическая и клиническая медицина. 2009; 4: 183-186.
  2. Жариков А. Ю., Зверев Я. Ф., Брюханов В. М. и др. Механизм формирования кристаллов при оксалатном нефролитиазе. Нефрология. 2009; 13 (4): 37-50.
  3. Тагиров Н. С., Назаров Т. Х., Васильев А. Г., Лихтшангоф А. З., Лазаренко И. Б., Маджидов С. А., Ахмедов М. А. Опыт применения чрескожной нефролитотрипсии и контактной уретеролитотрипсии в комплексном лечении мочекаменной болезни. Профилактическая и клиническая медицина. 2012; 4: 30-33.
  4. Трашков А. П., Васильев А. Г., Дементьева Е. А. и др. Сравнительная характеристика нарушений работы плазменного компонента системы гемостаза крыс при развитии экспериментальных опухолей различного гистологического типа. Вестник Российской военно-медицинской академии. 2011; 1: 148-153.
  5. Indridason O. S., Birgisson S., Edvardsson V. O. et al., Scand. J. Urol. Nephrol. 2009; 40 (3), 215-220.
  6. Romero V., Akpinar H., Assimos D. G., Rev. Urol. 2010; 12 (2-3), 86-96.

Statistics

Views

Abstract - 431

PDF (Russian) - 396

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions


Copyright (c) 2015 Tagirov N.S., Trashkov A.P., Balashov L.D., Balashov N.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies