Temperature imbalance and fever

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The ability to have a body temperature that is independent of environment temperature is evolutionary acquisition. Thanks to him, organisms can control the intensity of metabolism to increase body temperature. Homoiothermic animals can maintain an optimum body temperature via the heat transfer into the environment. An optimal level of temperature is necessary for activity of most enzymes, the implementation of metabolic reactions in cells. The viscosity of blood and extracellular fluids, the surface tension of the surfactant, swelling colloids of the interstitial space depend on the temperature inside. The excitation of cells, muscle contraction, secretion, absorption, locomotor activity and phagocytic properties of neutrophils also depend on the temperature of the tissues. Fever is pathological process a temporary increasing of body temperature for homoiothermal animals and humans. The process starts due to cytokines exogenous and endogenous origin. Cytokines rebuild the system of thermoregulation. Fever is protective response to damaged but may be redundant. Tachycardia at a fever promotes arrhythmias and may be complicated by the development of acute heart failure. Critical temperature decrease with profuse sweating can cause collapse. Fever in pregnant women in the early stages of placentation provokes violations and defects of the neural tube of the embryo. Fever leads to accumulation of ketonic substances in the blood due to incomplete lipolysis. Ketoacidosis with fever in young patients is the cause of hyperthermic convulsions. The negative effects of fever forced to resort to antipyretic therapy and measures to increase heat dissipation.

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About the authors

Lidiya Ivanovna Kalyuzhnaya

Saint Petersburg State Pediatric Medical University

Email: terrestra@mail.ru
MD, PhD, Dr Med Sci, Associate Professor. Department of Pathologic physiology courses immunopathology and Medical Informatics

Dmitriy Alekseevich Zemlyanoy

Saint Petersburg State Pediatric Medical University

Email: zemlianoj@mail.ru
Assistant Professor. Department of General Hygiene


  1. Ветров В. П., ред. Рациональное применение антипиретиков у детей: пособие для врачей. М.: МИА. 2002.
  2. Зайчик А. Ш., Чурилов Л. П. Общая патофизиология. СПб.: ЭЛБИ. 2001.
  3. Судаков К. В. ред. Нормальная физиология: Курс физиологии функциональных систем. М.: МИА. 1999.
  4. Литвицкий П. Ф. ред. Патофизиология. Курс лекций. М.: Медицина. 1995.
  5. Шанин В. Ю. ред. Патофизиология. СПб.: ЭЛБИ-СПБ. 2005.
  6. Тимченко В. Н., Павлова Е. Б. Современные подходы к терапии лихорадки у детей с инфекционной патологией. Лечащий врач. 2008: 8. Доступен по: http://www.lvrach.ru/2008/08/5618933 (дата обращения 02.07.2012).



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Copyright (c) 2015 Kalyuzhnaya L.I., Zemlyanoy D.A.

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