Characteristics of pregnancy as determinants of cardiac oscillator of a baby in the early neonatal period of life

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Abstract


In order to assess the influence of course of pregnancy upon rate and rhythm of heartbeat of a baby in the early neonatal period of life, parameters of babies’ cardiac oscillators were described in terms of power spectral density function calculated for rows of 100-250 consecutive ECG RR-intervals registered during orthodox sleep. Correlation of heart rhythm characteristics, ECG patterns of a baby during first 5 days after delivery and parameters of pregnancy described both in terms of nosology and symptoms (122 parameters in total) were analyzed. 160 newborns were enrolled in the study. Drug abuse, impossi-bility to fill in the query form or informal consent, severe disease of baby, gestational age less than 28 weeks and/or body weight at birth less than 1500 grams were specified as major exclusion criteria. It was shown that preeclampsia during the first half of pregnancy and women’s illness, associated with body temperature higher than 38 degrees Celsius after 8 week of pregnancy are among major determinants of babies’ cardiac oscillator in the early neonatal period of life, but they don’t affect the ECG wave amplitude and the duration of PQ and QT intervals. Pregnancy complicated during the first half promotes bradycardia and high heart rate variability and pregnancy complicated during the second half promotes tachycardia and low heart rate variability in babies during at least 5 days after delivery. Hypothetical spatial models of pacemaker areas were proposed for cases of normal pregnancy, pregnancy complicated in the first half and pregnancy complicated in the second half.

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About the authors

Ahmad Wakah

Independent Hospital

Email: wakah@hotmail.com
MD, PhD, Сardiologist

Irina Vladimirovna Solodkova

Saint Petersburg State Pediatric Medical University

Email: isolodkova@mail.ru
MD, PhD, Associate Professor, Chair of Hospital Pediatrics

Tat’yana Leonidovna Kornishina

Saint Petersburg State Pediatric Medical University

Email: tk.06@mail.ru
Assistant Professor, Chair of Hospital Pediatrics

Elizaveta Viktorovna Malkina

Saint Petersburg State Pediatric Medical University

Email: elizaveta.malkina23@mail.ru
MD, PhD, Assistant Professor, Chair of Hospital Pediatrics

Ol’ga Viktorovna Shadrina

Yakut Research Center for Complex Medical Problems

Email: shadrinaolga@rambler.ru
MD, PhD, Researcher

Andrey Viktorovich Adrianov

Saint Petersburg State Pediatric Medical University

Email: adrianov-av@mail.ru
MD, PhD, Professor, Chair of Hospital Pediatrics

Vyacheslav Grigoryevich Chasnyk

Saint Petersburg State Pediatric Medical University

Email: chasnyk@gmail.com
MD, PhD, Dr Med Sci, Professor, Head of the Department of Hospital Pediatrics

References

  1. Макаров Л. М. Холтеровское мониторирование. М.: Медицина; 2000.
  2. Макаров Л. М. Лекарственная терапия нарушений ритма сердца у детей. Педиатрия. 2003; 2: 61-65.
  3. Мищенко О. П., Климова Н. В., Савченко Е. А. и соавт. Нарушения сердечного ритма в педиатрической практике. Методическое пособие для врачей-педиатров. Благовещенск; 2004.
  4. Часнык В. Г. Клинические основы использования анализа структуры ритма сердца в автоматизированных системах оценки состояния здоровья детей. Автореферат дис… д-ра. мед. наук. СПб.; 1994.
  5. Часнык В. Г., Солодкова И. В., Аврусин С. Л., Дубко М. Ф., Шадрина О. В., Ваках Ахмад. Влияние патологии беременности на характеристики ритмической деятельности сердца ребенка. Экология человека. 2009; 5: 54-9.
  6. Anatoliotaki M., Papagiannis J., Stefanaki S. et al. Accelerated ventricular rhythm in the neonatal period: A review and two new cases in asymptomatic infants with an apparently normal heart. Acta Paediatr. 2004; 93: 1397- 400.
  7. Bendat J., Piersol A. Measurement and analysis of random processes. M.: Mir; 1974.
  8. Bisgaard H., Vissing N. H., Carson C. G., Bischoff A. L., Følsgaard N. V., Kreiner-Møller E., Chawes B. L., Stokholm J., Pedersen L., Bjarnadóttir E., Thysen A. H., Nilsson E., Mortensen L. J., Olsen S. F., Schjørring S., Krogfelt K. A., Lauritzen L., Brix S., Bønnelykke K. Deep phenotyping of the unselected COPSAC 2010 birth cohort study. Clin Exp Allergy. 2013; 43 (12): 1384-94.
  9. Bonnemeier H., Ortak J., Wiegand U. K., et al. Accelerated idioventricular rhythm in the post-thrombolytic era: Incidence, prognostic implications, and modulating mechanisms after direct percutaneous coronary intervention. Ann Noninvasive Electrocardiol. 2005; 10: 179-87.
  10. Bosquet L., Merkari S., Arvisais D., Aubert A. Is heart rate a convenient tool to monitor over-reaching? A systematic review of the literature. Br. J. Sports Med. 2008; 42 (9): 709-14.
  11. Cerutti S., Hoyer D., Voss А. Multiscale, multiorgan and multivariate complexity analyses of cardiovascular regulation. Phil Trans R Soc A. 2009; 367 (1892): 1337-58.
  12. Chang Y.L., Hsieh P. C., Chang S. D., Chao A. S., Liang C.C., Soong Y. K. Perinatal outcome of fetus with isolated congenital second degree atrioventricular block without maternal anti-SSA/Ro-SSB/La antibodies. Eur J Obstet Gynecol Reprod Biol. 2005; 122 (2): 167-71.
  13. Chmurzynska A. Fetal programming: link between early nutrition, DNA methylation, and complex diseases. Nutr.Rev. 2010; 68 (2): 87-98.
  14. Di Rienzo M., Parati G. Radaelli A., Castiglioni P. Baroreflex contribution to blood pressure and heart rate oscillations: time scales, time-variant characteristics and nonlinearities. Phil Trans R Soc A. 2009; 367 (1892):1301-18.
  15. Guyton A. C., Hall. E. Textbook of Medical Physiolopgy. 11th edition. Elsevier Sanders. 2006.
  16. Huikuri H. V., Perkiomaki J. S, Maestri R., Pinna G. D. Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics. Phil Trans R Soc A. 2009; 367 (1892): 1223-38.
  17. Jacobsen S. C., Gillberg L., Bork-Jensen J., Ribel-Madsen R., Lara E., Calvanese V., Ling C., Fernandez A.F., Fraga M. F., Poulsen P., Brøns C., Vaag A. Young men with low birth weight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding. Diabetologia. 2014; 57 (6): 1154-58.
  18. Massina Martial M., Bourguignonta Astrid, Gérardb Paul. Study of Cardiac Rate and Rhythm Patterns in Ambulatory and Hospitalized Children. Cardiology. 2005; 103: 174-79.
  19. Sachdeep S. Rehsia, Dion Pepelassis, Ilan Buffo-Sequeira. Accelerated ventricular rhythm in healthy neonates. Paediatr Child Health. 2007; 12 (9): 777-79.
  20. Scheer F. A., Hilton M. F., Mantzoros C. S., Shea S. A. From the Cover: adverse metabolic and cardiovascular consequences of circadian misalignment. PNAS.2009; 106 (11): 4453-58.
  21. Weinert D. Ontogenetic Development of the Mammalian Circadian System. Chronobiology International. 2005; 22 (2): 179-205.
  22. Ziemssen T., Reimann M., Gasch J., Rudiger H. Trigonometric regressive spectral analysis: an innovative tool for evaluating the autonomic nervous system. J Neural Transm. 2013; 120 Suppl 1: 27-33.
  23. The American Heritage Medical Dictionary. Доступно: http://medical-dictionary.thefreedictionary.com/cardiac+dysrhythmia (цитировано 19.10.2014).

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Copyright (c) 2014 Wakah A., Solodkova I.V., Kornishina T.L., Malkina E.V., Shadrina O.V., Adrianov A.V., Chasnyk V.G.

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