Characteristics of the immune response in children with atopic desoders

Abstract


The study of the immune status of immunopathological reactions and spectral sensitization in children with atopic dermatitis (215 children) and atopic bronchial asthma (197 children) aged 1 month to 17 years. The immune status was investigated by immunological tests of first level, subpopulations of lymphocytes by flow cytome-try, allergodiagnosis, diagnosis of autoimmune antibodies-enzyme-linked immunosorbent assay. Defined heterogeneity of immune system disorders, age-related features of sensitization to the household, food, epidermal and other allergens, the production of IgG autoantibodies to tissue antigens. The study of lymphocyte subpopulations indicates the presence of differences in the cellular immune re-sponse in children with atopic dermatitis and atopic asthma. The allergens that accumulate in the body have a direct effect on the functional activity of phagocytes. The study of the immune status in children with atopic allergic diseases it is necessary to conduct a reasonable individual pathogenic immune to improve the effectiveness of standard therapy, reduced the severity of the disease, frequency of exacerbations, and reduce the frequency and severity of comorbidity. Determination of specific IgE to a wide range of aller-gens, it is recommended to include in the scheme is mandatory labo-ratory examination of patients with atopic allergies. During the ex-amination and treatment of patients suffering from allergic diseases, it is necessary to consider the possibility of the presence of concomitant fungal sensitization. Measures to eliminate significant causal allergens should include correction of the child’s nutrition, control over the environment and the remediation of foci of chronic infection and normalization of the intestinal microflora. Immunore-habilitation children with allergopathology should be carried out taking into account the possible presence and activity of the auto-immune process.

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About the authors

Olga Petrovna Gurina

Saint Petersburg State Pediatric Medical University

Email: ol.gurina@yandex.ru
MD, PhD, Senior Researcher, Head of the Laboratory of Clinical Immunology

Elena Aleksandrovna Dementyeva

Saint Petersburg State Pediatric Medical University

Email: zorra2@yandex.ru
Junior Researcher

Aleksandr Evgenevich Blinov

Saint Petersburg State Pediatric Medical University

Email: alex.blinov@mail.ru
Senior Researcher

Olga Nikolaevna Varlamova

Saint Petersburg State Pediatric Medical University

Researcher

Vera Ivanovna Timokhina

Saint Petersburg State Pediatric Medical University

MD, PhD, Senior Researcher

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Copyright (c) 2014 Gurina O.P., Dementyeva E.A., Blinov A.E., Varlamova O.N., Timokhina V.I.

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