Cytomegalovirus infection in the patients with inflammatory bowel disease

Abstract


Cytomegalovirus infection of the gastrointestinal tract is a relatively common occurrence in patients receiving immunosuppressive drugs, those infected with HIV, or those who are transplantant recepients. CMV infection may be diagnosed if typical intranuclear inclusion bodies are seen on standard hematoxylin and eosin (H&E) stain. However, the sensitivity of H&E exam for CMV infection is low. Immunohistochemistry (IHC) exam performed on colon biopsy specimens is more sensitive than routine histologic exam and has excellent specificity. Currently IHC is considered the gold standard for detecting CMV CMV infection in patients with refractory or complicated IBD should be ruled out before aggressive immunosuppressive therapy for treatment-resistant disease to decrease morbidity and mortality.

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About the authors

Darya Olegovna Markova

Saint-Petersburg State Pediatric Medical University

Email: dashkasobk@mail.ru
Paediatrician

Ruslan Abdullayevich Nasyrov

Saint-Petersburg State Pediatric Medical University

Email: rrmd99@mail.ru
MD, PhD, Professor, Head of the Department of Pathological Anatomy

Mariya Olegovna Revnova

Saint-Petersburg State Pediatric Medical University

Email: revnoff@mail.ru
MD, PhD, Professor, Head of the Сlinical Department

References

  1. Ершов Ф. И., Оспельникова Т. П. Современный арсенал антигерпетических лекарственных средств // Consilium Medicum. — 2001. — Т. 04, № 3.
  2. Никонов А. П., Асцатурова О. Р. Цитомегаловирусая инфекция // Consilium Medicum (Педиатрия). — 2009, № 1.
  3. Румянцев В. Г., Щиголева Н. Е. Болезнь Крона в детском возрасте // Consilium Medicum. — 2002. — Т. 04, № 6.
  4. Самохин П. А. Цитомегаловирусная инфекция у детей: Клинико-морфологические аспекты. — М.: Медицина, 1987. — 159 с.
  5. David A. Bobak. Gastrointestinal Infection Caused by Cytomegalovirus // Current Infectious Disease Reports. — 2003. — Vol. 5. — P. 101–107.
  6. Doherty P. Immunologist. — 1995. — Vol. 3(5). — P. 231–233.
  7. Dubinsky M. C. Serologic and laboratory markers in prediction of the disease course in inflammatory bowel disease // World J. Gastroenterol. — 2010. — Vol. 16(21). — P. 2604–2608.
  8. Haywood L., Abernathy B. Infection // Sem Perinatol. — 1998. — Vol. 22(4). — P. 260–266.
  9. Herpesvirus Infections in Pregnancy // The 7th Ann. Meeting of the International Herpes Management Forum /Whitley R. J., Weber T., Pass R. Eds. — 1999. — P. 40–60.
  10. Kaniel A., Lashner B. Cytomegalovirus colitis complicating inflammatory bowel disease // Am. Journal Gastroenterology. — 2006. — Vol. 101. — P. 2857–2865.
  11. Karakozis S., Gongor E., Caceres M. et al. Life-threatening cytomegalovirus colitis in the immunocompetent patient: report of case and review of the literature. // Dis. Colon. Rectum. — 2001. — Vol. 44. — P. 1716–1720.
  12. Klemola E., Kaariainen L. Cytomegalovirus as a possible cause of a disease resembling infections mononucleosis // BMJ. — 1965. — Vol. 2. — P. 1099–1102.
  13. Maha M. Maher, Mahmoud I. Nassar. Acute Cytomegalovirus Infection Is a Risk Factor in Refractory and Complicated Inflammatory Bowel Disease. — Springer Science+Business Media, LLC. — 2008.
  14. Sissons J. G. P., Carmishael A. J. Clinical aspects and management of cytomegalovirus infection // J. Infection. — 2002. — Vol. 44 — P. 78–83.

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Copyright (c) 2013 Markova D.O., Nasyrov R.A., Revnova M.O.

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