Contemporary aspects of pathogenetically substantiated therapy of adenomyosis

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Abstract


The purpose of our study was to assess the effectiveness of the use of drugs containing indole-3-carbinol and epigallocatechin-3 gallate in combination with effective natural methods (TES-therapy and hirudotherapy) depending on the degree of morphological adenomyosis. The study involved 205 women with diffuse adenomyosis. Based on survey data from 205 women surveyed in 67 verified adenomyosis first degree (Group 1), 79 - second degree adenomyosis (group 2), and 59 - third degree adenomyosis (group 3). Doppler results showed that in patients with adenomyosis first degree nizkorezistentny uterine blood flow was observed. Improvement of clinical symptoms of the disease, increasing the numerical values of R & D in the uterine arteries at the first degree adenomyosis indicates pathogenic effects of the proposed treatment. At the same time in patients with adenomyosis II-III degree was observed with highly bloodstream, indicating the deterioration of blood flow in the uterine vascular basin, as evidenced by some of hemostasis. Thus, studies have provided credible evidence pathogenesis mediated relations between the characteristics of the circulation of the uterus, the processes of neoangiogenesis, proliferation in the myometrium and the extent of spread of the disease, which will choose the appropriate methods of conservative treatment. Using drugs and Indinol epigallat affecting the basic pathogenetic mechanisms of adenomyosis, opens a new direction in the treatment of this disease, and effective natural methods - new opportunities in the treatment of adenomyosis.

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About the authors

Arutyun F Arutyunyan

St. Petersburg State Pediatric Medical University

Author for correspondence.
Email: h.harutyunyan76@mail.ru

Russian Federation MD, PhD, Associate Professor

Sergey N Gaydukov

St. Petersburg State Pediatric Medical University

Email: gaiducovsn@rambler.ru

Russian Federation MD, PhD, Dr Med Sci, Professor, Head

Vitaly N Kustarov

Federal Almazov North-West Medical Research Centre

Email: prof.kustarov@gmail.com

Russian Federation MD, PhD, Dr Med Sci, Professor

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Copyright (c) 2016 Arutyunyan A.F., Gaydukov S.N., Kustarov V.N.

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