Diagnosis and treatment of transient neonatal thrombocytopenia (Draft clinical recommendations for discussion by specialists)

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Transient neonatal thrombocytopenia occurs with a frequency of 0.7–0.9% and is divided by etiological factor into primary (alloimmune and transimmune) and secondary (symptomatic) thrombocytopenia, according to the time of occurrence of thrombocytopenia is divided into early and late. The main clinical manifestation of thrombocytopenia is hemorrhagic syndrome of varying severity, which occurs in 20–30% of newborns with thrombocytopenia, in other newborns thrombocytopenia is asymptomatic. The most severe clinical symptom is intracranial hemorrhages, which occur in 10–30% of cases. The most common types of bleeding of the platelet-vascular type are petechiae, ecchymoses, nosebleeds, melena, hematuria, cephalohematoma and other types of bleeding. In dynamics, symptoms of posthemorrhagic anemia may appear with massive bleeding (pallor, tachycardia, tachypnea, decreased blood pressure). The main criterion for the diagnosis of transient neonatal thrombocytopenia is a decrease in the number of platelets below the reference values for a given gestational and chronological age of a newborn child. To diagnose the type of thrombocytopenia, a thorough collection of maternal anamnesis is necessary, examination of parents if they suspect the immune nature of the disease, diagnosis of the disease as a result of which thrombocytopenia has developed, if it is secondary. Correction of thrombocytopenia, if indicated, is carried out by intravenous administration of platelet concentrate. If the immune nature of thrombocytopenia with severe thrombocytopenia is suspected and/or the presence of moderate and higher hemorrhagic syndrome, the administration of normal human immunoglobulin is recommended. If immunoglobulin therapy for immune thrombocytopenia is ineffective, glucocorticoids are prescribed.

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作者简介

Dmitry Ivanov

Saint Petersburg State Pediatric Medical University

Email: delopro@gpmu.org.ru
ORCID iD: 0000-0002-0060-4168
SPIN 代码: 4437-9626

MD, PhD, Dr. Sci. (Medicine), Professor, Chief neonatologist of the Ministry of Health of the Russian Federation, Head of the Department of Neonatology with Сourses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education, Rector

俄罗斯联邦, Saint Petersburg

Galina Chumakova

Saint Petersburg State Pediatric Medical University

编辑信件的主要联系方式.
Email: zelchum-neo@yandex.ru
ORCID iD: 0000-0001-5353-4610
SPIN 代码: 1821-0198

MD, PhD, Dr. Sci. (Medicine), Professor of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Ekaterina Balashova

Research Center for Obstetrics, Gynecology and Perinatology

Email: katbal99@gmail.com
ORCID iD: 0000-0002-3741-0770
SPIN 代码: 1335-1489

MD, PhD, Assistant of the Department of Neonatology

俄罗斯联邦, Moscow

Tamara Belousova

Novosibirsk State Medical University

Email: belousovatv03@yandex.ru
ORCID iD: 0000-0002-4234-9353
SPIN 代码: 9651-0155

MD, PhD, Dr. Sci. (Medicine), Professor, Honored Doctor of Russia, Head of the Department of Pediatrics and Neonatology

俄罗斯联邦, Novosibirsk

Elena Bem

Saint Petersburg State Pediatric Medical University

Email: e.bohm@inbox.ru
ORCID iD: 0009-0008-9337-5667
SPIN 代码: 2811-5938

MD, PhD, Assistant of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Anastasia Kazantseva

Saint Petersburg State Pediatric Medical University

Email: enotz@inbox.ru
ORCID iD: 0000-0002-1234-9416
SPIN 代码: 7175-8776

Hematologist, Oncohematology Department

俄罗斯联邦, Saint Petersburg

Marina Levadneva

Saint Petersburg State Pediatric Medical University

Email: m-lev11@yandex.ru
ORCID iD: 0000-0001-6716-7567
SPIN 代码: 2780-6674

Head of the Department of Newborn Physiology at the Perinatal Center, Assistant of the Department of Neonatology with Сourses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Irina Myznikova

Saint Petersburg State Pediatric Medical University

Email: irinayurko2014@yandex.ru
ORCID iD: 0000-0002-8624-1854

Head of the Department of Pathology of Newborns and Young Children of the Perinatal Center, Assistant of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Svetlana Pavlova

Saint Petersburg State Pediatric Medical University

Email: svetlanapav.spb@mail.ru
ORCID iD: 0000-0001-5423-0950
SPIN 代码: 1761-4768

Assistant Professor of the Department of Neonatology with courses of Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Aleksandra Panchenko

Saint Petersburg State Pediatric Medical University

Email: sashawomen18@mail.ru
ORCID iD: 0000-0003-2313-3941
SPIN 代码: 9552-2350

MD, PhD, Dr. Sci. (Medicine), Professor of the Department of Neonatology with Courses of Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Ksenia Pshenichnaya

Saint Petersburg State Pediatric Medical University

Email: kpshenichnay@yandex.ru
ORCID iD: 0009-0001-7172-7931
SPIN 代码: 8603-5705

MD, PhD, Dr. Sci. (Medicine), Professor of the Professor I.M. Vorontsov Department of Children’ Diseases of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Larisa Romanova

Saint Petersburg State Pediatric Medical University

Email: l_romanova2011@mail.ru
ORCID iD: 0000-0003-0828-352X
SPIN 代码: 6460-5491

MD, PhD, Associate Professor of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Nina Subora

Saint Petersburg State Pediatric Medical University

Email: matchenkova@inbox.ru
ORCID iD: 0000-0001-9153-3803
SPIN 代码: 6943-3382

Hematologist, Oncohematology Department

俄罗斯联邦, Saint Petersburg

Larisa Fedorova

Saint Petersburg State Pediatric Medical University

Email: arslarissa@rambler.ru
ORCID iD: 0000-0001-9747-762X
SPIN 代码: 5474-0902

MD, PhD, Associate Professor of the Department of Neonatology with courses in Neurology and Obstetrics and Gynecology of Faculty of Retraining and Additional Professional Education

俄罗斯联邦, Saint Petersburg

Ekaterina Yakovleva

Saint Petersburg State Pediatric Medical University

Email: eeiakovleva@mail.ru
ORCID iD: 0000-0002-0270-0217
SPIN 代码: 6728-7340

MD, PhD, Head of the Department of Clinical Pharmacology, Associate Professor of the Department of Pharmacology with the course of Clinical Pharmacology and Pharmacoeconomics

俄罗斯联邦, Saint Petersburg

参考

  1. Borovkova EI, Romanovskaya VV, Koblova AA, Timoshchuk ED. Neonatal alloimmune thrombocytopenia: difficulties in diagnosis and therapy. Topical Issues of Women’s Health. 2022;(1):26–31. EDN: DJWXNC doi: 10.46393/2713122Х_2022_1_26
  2. Clinical Guidelines — Idiopathic thrombocytopenic purpura (ITP) in adults. Moscow. 2021. 36 p.
  3. Maschan AA, Rumyantsev AG, Kovaleva LG, et al. Guidelines of Russian expert council on diagnostic and therapy of patients with primary immunne thrombocytopenia. Oncohematology. 2010;5(3): 36–45. EDN: NCMPZR
  4. Melikyan AL, Pustovaya EI, Tsvetaeva NV, et al. National clinical guidelines for the diagnosis and treatment of primary immune thrombocytopenia (idiopathic thrombocytopenic purpura) in adults. Russian Journal of Hematology and Transfusiology. 2015;60(1): 44–56. EDN: TRKDHD
  5. Volodin NN, Degtyarev DN, editors. Neonatology: national guide: in 2 vol. Moscow: GEOTAR-Media; 2023. 743 c. (In Russ.)
  6. Ostroumova OD, Kravchenko EV, Kochetkov AI. Drug-induced thrombocytopenia. Clinical Pharmacology and Therapy. 2019;28(4): 56–64. EDN: VLSMHY doi: 10.32756/0869-5490-2019-4-56-64
  7. Rumyantsev AG. Main characteristics of intravenous immunoglobulin preparations and indications for their use. Pediatric Hematology / Oncology and Immunopathology. 2011;10(2):39–50. EDN: OIMIMF
  8. Tretiakova OS, Sukhareva IA, Vasilenko SA, et al. Immune thrombocytopenia in children: steroid hormones or intravenous immunoglobulins? Pediatrics. Eastern Europe. 2015;(2):130–137. EDN: TYORDH
  9. Khaspekova SG, Shustova ON, Golovkina LL, Mazurov AV. Diagnostic markers and predictors of neonatal immune thrombocytopenia. Russian Journal of Hematology and Transfusiology. 2019;64(2): 198–210. EDN: JSFJUE doi: 10.35754/0234-5730-2019-64-2-198-210
  10. Shabalov NP. Neonatology: textbook. Vol. 2. Moscow: GEOTAR-Media; 2020. 752 p.
  11. Agapakis DI, Massa EV. A case of fenofibrate-induced immune thrombocytopenia: first report. P R Health Sci J. 2015;34(3):170–173.
  12. Alan T. Nurden and Paquita Nurden Inherited thrombocytopenias: history, advances and perspectives. Haematologica. 2020;105(8):2004–2019. doi: 10.3324/haematol.2019.233197
  13. Al-Nouri ZL, George JN. Drug-induced thrombocytopenia: an updated systematic review, 2012. Drug Saf. 2012;35(8):693–694. doi: 10.2165/11633310-000000000-00000
  14. Althaus J, Weir EG, Askin F, et al. Chronic villitis in untreated neonatal alloimmune thrombocytopenia: an etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy. Am J Obstet Gynecol. 2005;193(3 Pt 2):1100–1114. doi: 10.1016/j.ajog.2005.06.043
  15. uptodate.com [Internet]. Arnold DA. Drug-induced immune thrombocytopenia. UpToDate. 2020. [Cited: 2024 Oct 09]. Available from: https://www.uptodate.com/contents/drug-induced-immunethrombocytopenia.
  16. Aster RH. Drug-induced immune thrombocytopenia: an overview of pathogenesis. Semin Hematol. 1999;36(1):2–6.
  17. Aster RH. Immune thrombocytopenia caused by glycoprotein IIb/IIIa inhibitors. Chest. 2005;127(2 Suppl):53S-59S. doi: 10.1378/chest.127.2_suppl.53S
  18. Ault KA, Knowles C. In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Exp Hematol. 1995;23(9):996–1001.
  19. Ault KA, Rinder HM, Mitchell J, et al. The significance of platelets with increased RNA content (reticulated platelets). A measure of the rate of thrombopoiesis. Am J Clin Pathol. 1992;98(6): 637–646. doi: 10.1093/ajcp/98.6.637
  20. Baer VL, Lambert DK, Henry E, Christensen RD. Severe thrombocytopenia in the NICU. Pediatrics. 2009;124(6):e1095–e100. doi: 10.1542/peds.2009-0582
  21. Baker JM, Shehata N, Bussel J, et al. International collaboration for transfusion medicine guidelines (ICTMG). Postnatal intervention for the treatment of FNAIT: a systematic review. J Perinatol. 2019;39(10):1329–1339. doi: 10.1038/s41372-019-0360-7
  22. Batton E, Leibel SL. Immune-mediated neonatal thrombocytopenia. Neoreviews. 2022;23(7):e462–e471. doi: 10.1542/neo.23-7-e462
  23. Beiner ME, Simchen MJ, Sivan E, et al. Risk factors for neonatal thrombocytopenia in preterm infants. Am J Perinatol. 2003;20(1): 49–54. doi: 10.1055/s-2003-37948
  24. Berger M. Adverse effects of IgG therapy. J Allergy Clin Immunol Pract. 2013;1(6):558–566. doi: 10.1016/j.jaip.2013.09.012
  25. Bhat R, Kumar R, Kwon S, et al. Risk factors for neonatal venous and arterial thromboembolism in the neonatal intensive care unit — a case control study. J Pediatr. 2018;195:28–32. doi: 10.1016/j.jpeds.2017.12.015
  26. Boskabadi H, Mafinezhad S, Bagher F, Bozorgnia Y. Incidence of thrombocytopenia in idiopathic hyperbilirubinemic newborns. OA Maced J Med Sci. 2014;2(2):261–264. doi: 10.3889/oamjms.2014.043
  27. Bougie D, Aster R. Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood. 2001;97(12):3846–3850. doi: 10.1182/blood.v97.12.3846
  28. British committee for standards in haematology general haematology task force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol. 2003;120(4):574–596. doi: 10.1046/j.1365-2141.2003.04131.x
  29. Bussel JB, Berkowitz RL, Hung C, et al. Intracranial hemorrhage in alloimmune thrombocytopenia: stratified management to prevent recurrence in the subsequent affected fetus. Am J Obstet Gynecol. 2010;203(2):135.e1–14. doi: 10.1016/j.ajog.2010.03.011
  30. Chakraborty S, Roberts IAG. Platelets (Third Edition). Chapter 45 — Thrombocytopenia in the newborn. Michelson AD, editor. Elsevier: Academic Press, 2013. P. 929–952. doi: 10.1016/B978-0-12-387837-3.00045-6
  31. Chalmers EA. Neonatal thrombosis. J Clin Pathol. 2000;53(6): 419–423. doi: 10.1136/jcp.53.6.419
  32. Chiurazzi F, Villa MR, Rotoli B. Transplacental transmission of EDTA-dependent pseudothrombocytopenia. Haematologica. 1999;84(7):664.
  33. Christensen RD, Baer VL, Yaish HM. Thrombocytopenia in late preterm and term neonates after perinatal asphyxia. Transfusion. 2014;55(1):187–196. doi: 10.1111/trf.12777
  34. Christensen RD, Baer VL, Henry E, et al. Thrombocytopenia in small for gestational age infants. Pediatrics. 2015;136(2):e361–e370. doi: 10.1542/peds.2014-4182
  35. Christensen RD, Sola MC, Rimsza LM, et al. Pseudothrombocytopenia in a preterm neonate. Pediatrics. 2004;114(1):273–275. doi: 10.1542/peds.114.1.273
  36. Christensen RD. Platelet transfusion in the neonatal intensive care unit: benefits, risks, alternatives. Neonatology. 2011;100(3): 311–318. doi: 10.1159/000329925
  37. Conley EL, Coley KC, Pollock BG, et al. Prevalence and risk of thrombocytopenia with valproic acid: experience at a psychiatric teaching hospital. Pharmacotherapy. 2001;21(11):1325–1330. doi: 10.1592/phco.21.17.1325.34418
  38. Cremer M, Sola-Visner M, Roll S, et al. Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. Transfusion. 2011;51(12): 2634–2641. doi: 10.1111/j.1537-2995.2011.03208.x
  39. Curley A, Stanworth SJ, Willoughby K, et al. Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med. 2019;380(3):242–251. doi: 10.1056/NEJMoa1807320
  40. Curtis BR. Drug-induced immune thrombocytopenia: incidence, clinical features, laboratory testing, and pathogenic mechanisms. Immunohematology. 2014;30(2):55–65.
  41. de Vos TW, Winkelhorst D, Árnadóttir V, van der Bom JG, et al. Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective, cohort study. Lancet Haematol. 2022;9(11):e844–e853. doi: 10.1016/S2352-3026(22)00243-5
  42. de Vos TW, Winkelhorst D, de Haas M, et al. Epidemiology and management of fetal and neonatal alloimmune thrombocytopenia. Transfus Apher Sci. 2020;59(1):102704. doi: 10.1016/j.transci.2019.102704
  43. Del Vecchio A, Sola MC, Theriaque DW, et al. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion. 2001;41(6):803–808. doi: 10.1046/j.1537-2995.2001.41060803.x
  44. Del Vecchio A. Evaluation and management of thrombocytopenic neonates in the intensive care unit. Early Hum Dev. 2014;90(Suppl 2): S51–S55. doi: 10.1016/S0378-3782(14)50014-X
  45. Donato H. Neonatal thrombocytopenia: A review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia. Arch Argent Pediatr. 2021;119(3):e202–e214. doi: 10.5546/aap.2021.eng.e202
  46. Ferrer-Marin F, Chavda C, Lampa M, et al. Effects of in vitro adult platelet transfusions on neonatal hemostasis. J Thromb Haemost. 2011;9(5):1020–1108. doi: 10.1111/j.1538-7836.2011.04233.x
  47. Fustolo-Gunnink SF, Vlug RD, Smits-Wintjens VEH, et al. Early-onset thrombocytopenia in small-for-gestational-age neonates: a retrospective cohort study. PLOS ONE. 2016;11(5):e0154853. doi: 10.1371/journal.pone.0154853
  48. Fustolo-Gunnink SF, Huisman EJ, van der Bom JG, et al. Are thrombocytopenia and platelet transfusions associated with major bleeding in preterm neonates? A systematic review. Blood Rev. 2019;36:1–9. doi: 10.1016/j.blre.2018.10.001
  49. Garcia MG, Duenas E, Sola MC, et al. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol. 2001;21(7):415–420. doi: 10.1038/sj.jp.7210566
  50. George JN, Raskob GE, Shah SR et al. Drug-induced thrombocytopenia a systematic review of published case reports. Ann Intern Med. 1998;129(11):886–890. doi: 10.7326/0003-4819-129-11_part_1-199812010-00009
  51. Goel R, Josephson CD. Recent advances in transfusions in neonates/infants. F1000Res. 2018;7:F1000 Faculty Rev-609. doi: 10.12688/f1000research.13979.1
  52. Gomella TL, Cunningham MD. Gomella’s Neonatology. 8th edition. McGraw Hill; 2020. 1472 p.
  53. Haley KM. Neonatal venous thromboembolism. Front Pediatr. 2017;5:136. doi: 10.3389/fped.2017.00136
  54. Hasan R, Saifee NH. Benefits of lower neonatal platelet transfusion thresholds. Transfusion. 2021;61(6):1672–1675. doi: 10.1111/trf.16386
  55. Hauschner H, Rosenberg N, Seligsohn U, et al. Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers. Blood. 2015;126(5):661–664. doi: 10.1182/blood-2014-12-614446
  56. Josephson CD, Su LL, Christensen RD, et al. Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics. 2009;123(1):278–285. doi: 10.1542/peds.2007-2850
  57. Kahn DJ, Richardson DK, Billett HH. Inter-NICU variation in rates and management of thrombocytopenia among very low birth-weight infants. J Perinatol. 2003;23(4):312–316. doi: 10.1038/sj.jp.7210910
  58. Kalagiri RR, Choudhury S, Carder T, et al. Neonatal thrombocytopenia as a consequence of maternal preeclampsia. AJP Rep. 2016;6(1):e42–e47. doi: 10.1055/s-0035-1565923
  59. Kaplan C. Foetal and neonatal alloimmune thrombocytopaenia. Orphanet J Rare Dis. 2006;1:39. doi: 10.1186/1750-1172-1-39
  60. Kauzar M, Salahuddin I, Naveed A. Examine the frequency of thrombocytopenia in newborns with neonatal sepsis. Pakistan Journal of Medical Health Sciences. 2020;14(2):657–659.
  61. Khaspekova SG, Shustova ON, Golubeva NV, et al. Circulating antiplatelet antibodies in pregnant women with immune thrombocytopenic purpura as predictors of thrombocytopenia in the newborns. Platelets. 2019;30(8):1008–1012. doi: 10.1080/09537104.2018.1557615
  62. Koyama S, Tomimatsu T, Kanagawa T, et al. Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura. Am J Hematol. 2012;87(1):15–21. doi: 10.1002/ajh.22178
  63. Kush ML, Gortner L, Harman CR, Baschat AA. Sustained hematological consequences in the first week of neonatal life secondary to placental dysfunction. Early Hum Dev. 2006;82(1):67–72. doi: 10.1016/j.earlhumdev.2005.06.009
  64. Lieberman L, Greinacher A, Murphy MF, et al. Fetal and neonatal alloimmune thrombocytopenia: recommendations for evidence-based practice, an international approach. Br J Haematol. 2019;185(3):549–562. doi: 10.1111/bjh.15813
  65. MacQueen BC, Christensen RD, Henry E, et al. The immature platelet fraction: creating neonatal reference intervals and using these to categorize neonatal thrombocytopenias. J Perinatol. 2017;37(7):834–838. doi: 10.1038/jp.2017.48
  66. Mailman JF, Stigant C, Martinusen D. Moxifloxacin-induced immune-mediated thrombocytopenia in a chronic kidney disease patient receiving hemodialysis. Ann Pharmacother. 2014;48(7):919–922. doi: 10.1177/1060028014529929
  67. Lanzkowsky P. Manual of pediatric hematology and oncology. Elsevier: Academic Press; 2005. 832 p.
  68. Mehta P, Vasa R, Neumann L, Karpatkin M. Thrombocytopenia in the high-risk infant. J Pediatr. 1980;97(5):791–794. doi: 10.1016/s0022-3476(80)80272-1
  69. Mella M, Eddleman K. Neonatal alloimmune thrombocytopenia. Int J ClinTransf Med. 2015;3:29–40. doi: 10.2147/IJCTM.S51926
  70. Ming JY, Kathryn W, Kendall S. Maternal and neonatal idiopathic thrombocytopenic purpura. SOJ Pediatrics Clinical Neonatology. 2020;1(1):1–3. doi: 10.53902/SOJPCN.2020.01.000504
  71. Mishra S, Jaiswar S, Saad S, Tripathi S, et al. Platelet indices as a predictive marker in neonatal sepsis and respiratory distress in preterm prelabor rupture of membranes. Int J Hematol. 2021;113(2):199–206. doi: 10.1007/s12185-020-03025-2
  72. Murphy MF, Riordan T, Minchinton RM et al. Demonstration of an immune mediated mechanism of penicillin-induced neutropenia and thrombocytopenia. BrJ Haematol. 1983;55(1):135–160. doi: 10.1111/j.1365-2141.1983.tb01233.x
  73. Murray NA, Howarth LJ, McCloy MP, et al. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med. 2002;12(1):35–41. doi: 10.1046/j.1365-3148.2002.00343.x
  74. Muthukumar P, Venkatesh V, Curley A et al. Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions. Transfus Med. 2012;22(5):338–343. doi: 10.1111/j.1365-3148.2012.01171/
  75. de Alarcón PA, Werner EJ, Christense RD, Sola-Visner MC, editors. Neonatal hematology, pathogenesis, diagnosis, and management of hematologic problems. 3rd edition. Cambridge University Press. 2021. 490 p.
  76. New HV, Berryman J, Bolton-Maggs PH, et al. British committee for standards in haematology. Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol. 2016;175(5):784–828. doi: 10.1111/bjh.14233
  77. Ohno N, Kobayashi M, Hayakawa S, et al. Transient pseudothrombocytopenia in a neonate: transmission of a maternal EDTA-dependent anticoagulant. Platelets. 2012;23(5):399–400. doi: 10.3109/09537104.2011.624210
  78. Pacheco LD, Berkowitz RL, Moise KJ Jr, et al. Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. Obstet Gynecol. 2011;118(5):1157–1163. doi: 10.1097/AOG.0b013e31823403f4
  79. Parker CW. Hapten immunology and allergic reactions in humans. Arthr Rheum. 1981;24(8):1024–1036. doi: 10.1002/art.1780240808
  80. Peng T, Shan Y, Zhang P, Cheng G. Bleeding in neonates with severe thrombocytopenia: a retrospective cohort study. BMC Pediatr. 2022;22(1):730. doi: 10.1186/s12887-022-03802-4
  81. Perez Botero J, Reese JA, George JN, McIntosh JJ. Severe thrombocytopenia and microangiopathic hemolytic anemia in pregnancy: A guide for the consulting hematologist. Am J Hematol. 2021;96(12):1655–1665. doi: 10.1002/ajh.26328
  82. Peterec SM, Brennan SA, Rinder HM, et al. Reticulated platelet values in normal and thrombocytopenic neonates. J Pediatr. 1996;129(2):269–274. doi: 10.1016/s0022-3476(96)70253-6
  83. Provan D, Stasi R, Newland AC, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010;115(2):168–186. doi: 10.1182/blood-2009-06-225565
  84. Psaila B, Bussel JB. Platelets. Immune thrombocytopenia (ITP). Michelson AD, editor. Elsevier: Academic Press; 2013. P. 819–833.
  85. Ranieri MM, Bradley EF, Simon AB. Meloxicam-induced thrombocytopenia. Pharmacotherapy. 2014;34(2):e14–e17. doi: 10.1002/phar.1372
  86. Rayment R, Brunskill SJ, Soothill PW, et al. Antenatal interventions for fetomaternal alloimmune thrombocytopenia. Cochrane Database Syst Rev. 2011;(5):CD004226. doi: 10.1002/14651858.CD004226.pub3
  87. Reese JA, Nguyen LP, Buchanan GR, et al. Drug-induced thrombocytopenia in children. Pediatric Blood Cancer. 2013;60(12): 1975–1981.
  88. Intechopen.com [Internet]. Resch B. Thrombocytopenia in neonates platelets. IntechOpen; 2020. doi: 10.5772/intechopen.9285
  89. Ribeiro HS, Assunção A, Vieira RJ, Soares P. Platelet transfusions in preterm infants: current concepts and controversies — a systematic review and meta analysis. Eur J Pediatr. 2023;182(8):3433–3443. doi: 10.1007/s00431-023-05031-y
  90. Roberts I, Chakravorty S. Platelets. 44 — Thrombocytopenia in the newborn. 4th edition. Elsevier: Academic Press; 2019. P. 813–831.
  91. Roberts I, Stanworth S, Murray NA. Thrombocytopenia in the neonate. Blood Rev. 2008;22(4):173–186. doi: 10.1016/j.blre.2008.03.004
  92. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed. 2003;88(5): F359–F364. doi: 10.1136/fn.88.5.f359
  93. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113(11): 2386–2393. doi: 10.1182/blood-2008-07-162503
  94. Roganović J. Neonatal thrombocytopenia: a common clinical problem. Central European Journal of Paediatrics. 2015;11(2): 115–125. doi: 10.5457/P2005-114.117
  95. Salamon DJ, Nusbacher J, Stroupe T, et al. Red cell and platelet-bound IgG penicillin antibodies in a patient with thrombocytopenia. Transfusion. 1984;24:395–398. doi: 10.1046/j.1537-2995.1984.24585017827.x
  96. Saxonhouse MA, Manco-Johnson MJ. The evaluation and management of neonatal coagulation disorders. Semin Perinatol. 2009;33(1):52–65. doi: 10.1053/j.semperi.2008.10.007
  97. Sola MC, Slayton WB, Rimsza LM, et al. A neonate with severe thrombocytopenia and radio-ulnar synostosis. J Perinatol. 2004;24(8):528–530. doi: 10.1038/sj.jp.7211134
  98. Sola-Visner M, Leeman KT, Stanworth SJ. Neonatal platelet transfusions: New evidence and the challenges of translating evidence-based recommendations into clinical practice. J Thromb Haemost. 2022;20(3):556–564. doi: 10.1111/jth.15664
  99. Sparger K, Deschmann E, Sola-Visner M. Platelet transfusions in the neonatal intensive care unit. Clin Perinatol. 2015;42(3): 613–623. doi: 10.1016/j.clp.2015.04.009
  100. Sparger KA, Assmann SF, Granger S. Platelet transfusion practices among very-low-birth-weight infants. JAMA Pediatr. 2016;170(7):687–694. doi: 10.1001/jamapediatrics.2016.0507
  101. Stanworth SJ, Clarke P, Watts T, et al; Platelets and Neonatal Transfusion Study Group. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics. 2009;124(5):e826–e834. doi: 10.1542/peds.2009-0332
  102. Stanworth SJ, Mumford AD. How I diagnose and treat neonatal thrombocytopenia. Blood. 2023;141(22):2685–2697. doi: 10.1182/blood.2022018017
  103. Tan MW, Sklar GE. Pentoxifylline-induced thrombocytopenia: a case report. J Pharm Pract. 2015;28(6):572–576. doi: 10.1177/0897190015608274
  104. Morrone K. Thrombocytopenia in the newborn. NeoReviews. 2018;19(1):e34–e41. doi: 10.1542/neo.19-1-e34
  105. Tighe P, Rimsza LM, Christensen RD, et al. Severe thrombocytopenia in a neonate with congenital HIV infection. J Pediatr. 2005;146(3):408–413. doi: 10.1016/j.jpeds.2004.11.024
  106. Ulusoy E, Tüfekçi O, Duman N, et al. Thrombocytopenia in neonates: causes and outcomes. Ann Hematol. 2013;92(7):961–967. doi: 10.1007/s00277-013-1726-0
  107. van den Akker ES, Oepkes D, Lopriore E, et al. Noninvasive antenatal management of fetal and neonatal alloimmune thrombocytopenia: safe and effective. BJOG. 2007;114(4):469–473. doi: 10.1111/j.1471-0528.2007.01244.x
  108. van den Bemt PM, Meyboom RH, Egberts AC. Drug-induced immune thrombocytopenia. Drug Saf. 2004;27(15):1243–1252. doi: 10.2165/00002018-200427150-00007
  109. van der Lugt NM, van Kampen A, Walther FJ, et al. Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura. Vox Sang. 2013;105(3): 236–243. doi: 10.1111/vox.12036
  110. van Ommen CH, Heijboer H, Büller HR, et al. Venous thromboembolism in childhood: A prospective two-year registry in the Netherlands. J Pediatr. 2001;139(5):676–681. doi: 10.1067/mpd.2001.118192
  111. Veneri D, Franchini M, Randon F, et al. Thrombocytopenias: a clinical point of view. Blood Transfus. 2009;7(2):75–85. doi: 10.2450/2008.0012-08
  112. Venkatesh V, Curley A, Khan R, et al. A novel approach to standardised recording of bleeding in a high risk neonatal population. Arch Dis Child Fetal Neonatal Ed. 2013;98(3):F260–F263. doi: 10.1136/archdischild-2012-302443
  113. Visentin GP, Newman PJ, Aster RH. Characteristics of quinine and quinidineinduced antibodies specific for platelet glycoproteins IIb and Illa. Blood. 1991;77(12):2668–2676.
  114. von dem Borne AE, Pegels JG, van der Stadt RJ, et al. Thrombocytopenia associated with gold therapy: a drug-induced autoimmune disease? Br J Haematol. 1986;63(3):509–516. doi: 10.1111/j.1365-2141.1986.tb07528.x
  115. Wade EE, Rebuck JA, Healey MA, Rogers FB. H(2) antagonist-induced thrombocytopenia: is this a real phenomenon? Intensive Care Med. 2002;28(4):459–465. doi: 10.1007/s00134-002-1233-6
  116. Webert KE, Mittal R, Sigouin C, et al. A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura. Blood. 2003;102(13):4306–4311. doi: 10.1182/blood-2002-10-3317
  117. Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol. 2009;29(2):130–136. doi: 10.1038/jp.2008.141
  118. Winkelhorst D, Murphy MF, Greinacher A, et al. Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. Blood. 2017;129(11):1538–1547. doi: 10.1182/blood-2016-10-739656
  119. Winkelhorst D, Oostweegel M, Porcelijn L, et al. Treatment and outcomes of fetal/neonatal alloimmune thrombocytopenia: a nationwide cohort study in newly detected cases. Br J Haematol. 2019;184(6):1026–1029. doi: 10.1111/bjh.15216
  120. Yamada H, Kato EH, Kobashi G, et al. Passive immune thrombocytopenia in neonates of mothers with idiopathic thrombocytopenic purpura: incidence and risk factors. Semin Thromb Hemost. 1999;25(5):491–496. doi: 10.1055/s-2007-994956
  121. Zdravic D, Yougbare I, Vadasz B, et al. Fetal and neonatal alloimmune thrombocytopenia. Semin Fetal Neonatal Med. 2016;21(1):19–27. doi: 10.1016/j.siny.2015.12.004

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2. Fig. 1. Platelet Count in newborns in the first 3 days of life at gestational age from 22 to 42 weeks [117]

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3. Fig. 2. MPV in term and late preterm infants during the first 90 days after birth [117]

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4. Fig. 3. Immature platelet fraction (IPF %) on the day of birth depending on the gestational age [65]

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