Staphylococcal-scalded skin syndrome, a clinical case
- Authors: Milyavskaya I.R.1, Revnova M.O.1, Leina L.M.1, Felker E.Y.1, Mineeva O.K.1, Bolshakova E.S.1
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Affiliations:
- St. Petersburg State Pediatric Medical University
- Issue: Vol 13, No 2 (2022)
- Pages: 99-107
- Section: Clinical observation
- URL: https://journals.eco-vector.com/pediatr/article/view/109262
- DOI: https://doi.org/10.17816/PED13299-107
- ID: 109262
Cite item
Abstract
Staphylococcal scalded skin syndrome (SSSS) is the most severe form of staphyloderma in newborns and young children. The disease is associated with the production of exfoliatin toxin by Staphylococcus aureus, which breaks down desmoglein 1 in the cells of the granular layer of the epidermis, which leads to the formation of superficial blisters. The differential diagnosis is with toxic epidermal necrolysis (Lyell’s syndrome, TEN). The development of TEN is more often associated with the use of drugs such as sulfonamides, anticonvulsants, antibiotics, etc. As an illustration of the difficulty of differential diagnosis, we present our clinical observation of a 1-year-old girl. The girl was admitted in serious condition to the intensive care unit with a diagnosis of Lyell’s syndrome. At the admission, extensive skin lesions were noted in the form of multiple flaccid blisters and erosions. At the same time, the mucous membranes were not affected. The department was diagnosed with staphylococcal scalded skin syndrome. Thus, the differential diagnosis of the syndrome of SSSS and TEN presents certain difficulties. When making a diagnosis, it is necessary to take into account the anamnesis, clinical manifestations, paying special attention to the defeat of the mucous membranes.
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About the authors
Irina R. Milyavskaya
St. Petersburg State Pediatric Medical University
Email: imilyavskaya@yandex.ru
MD, PhD, Associate Professor Department of Dermatovenerology
Russian Federation, Saint PetersburgMaria O. Revnova
St. Petersburg State Pediatric Medical University
Email: revnoff@mail.ru
MD, PhD, Dr. Med. Sci., Professor, Head of the A.F. Tur Department of Pediatrics
Russian Federation, Saint PetersburgLarisa M. Leina
St. Petersburg State Pediatric Medical University
Email: larisa.leina@mail.ru
MD, PhD, Associate Professor Department of Dermatovenerology
Russian Federation, Saint PetersburgEvgeny Yu. Felker
St. Petersburg State Pediatric Medical University
Email: felkeru@gmail.com
MD, PhD, Head of the Department of Anesthesiology and Intensive Care
Russian Federation, Saint PetersburgOlga K. Mineeva
St. Petersburg State Pediatric Medical University
Email: o-mine@ya.ru
Dermatovenereologist
Russian Federation, Saint PetersburgElena S. Bolshakova
St. Petersburg State Pediatric Medical University
Author for correspondence.
Email: 1kozgpmu@gmail.com
Head of Dermatovenerology Department
Russian Federation, Saint PetersburgReferences
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