Prognostic potential of hematological inflammatory indexes for in vitro fertilization

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Abstract

The problem of infertility now is relevant and has high social significance both for the Russian Federation and for many other countries, due to its widespread occurrence. Overcoming infertility with in vitro fertilization (IVF) is still a difficult task: only about a third of women achieve pregnancy with this type of treatment. Reliable tools are needed to predict the success of the onset and development of pregnancy after IVF. The indicators used to predict the IVF effectiveness do not assess the inflammatory status of patients, which can significantly contribute to the receptivity of the endometrium, and, consequently, to the achievement of implantation. In recent years, enough information about the possible use of hematological indexes as parameters of a systemic inflammatory response, especially with a subclinical nature, when other inflammatory markers remain within normal values, has been accumulated. Inflammatory hematological indexes are calculated as the ratio of different populations of blood cells: NLR (Neutrophil-lymphocyte ratio), PLR (Platelet-lymphocyte ratio), LMR (Lymphocyte-monocyte ratio), SII (Systemic inflammatory index), SIRI (Systemic inflammatory response index) and others. They can potentially serve as simple and cost-effective predictive markers for the IVF success. Further study of the prognostic role of inflammatory hematological indexes in infertility associated with subclinical inflammation and their validation in prospective studies will improve treatment algorithms and increase the IVF effectiveness in such patients.

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About the authors

Dmitry O. Ivanov

Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: doivanov@yandex.ru
ORCID iD: 0000-0002-0060-4168
SPIN-code: 4437-9626

MD, PhD, Dr. Sci. (Medicine), Professor, Chief Freelance Specialist Neonatologist of Ministry of Health of the Russian Federation, Rector, Head of the Department of Neonatology with Courses in Neurology and Obstetrics-Gynecology of the Faculty of Postgraduate and Additional Professional Education

Russian Federation, Saint Petersburg

Tatiana A. Krivolesova

Saint Petersburg State Pediatric Medical University

Email: Krivolesova.ta@mail.ru
ORCID iD: 0000-0003-3559-4876
SPIN-code: 3863-9689

Head of the Department of Assisted Reproductive Technologies

Russian Federation, Saint Petersburg

Lidia P. Sigareva

Saint Petersburg State Pediatric Medical University

Email: sigaryowa@yandex.ru
ORCID iD: 0000-0002-4371-1510
SPIN-code: 9318-9050

Junior researcher of Experimental Medicine Laboratory at Scientific Research Center, PhD student

Russian Federation, Saint Petersburg

Vitaly A. Reznik

Saint Petersburg State Pediatric Medical University

Email: vitaliy-reznik@mail.ru
ORCID iD: 0000-0002-2776-6239
SPIN-code: 9761-6624

MD, PhD, Dr. Sci. (Medicine), Chief Physician of the Clinic, Assistant Professor of the Department of Neonatology with Courses in Neurology and Obstetrics-Gynecology of the Faculty of Postgraduate and Additional Professional Education

Russian Federation, Saint Petersburg

Olga E. Savelieva

Saint Petersburg State Pediatric Medical University

Email: olga_chechina@mail.ru
ORCID iD: 0000-0002-0301-8455
SPIN-code: 9633-9449

MD, PhD, Dr. Sci. (Medicine), Head of Experimental Medicine Laboratory at Scientific Research Center, Professor of Biological Chemistry Department

Russian Federation, Saint Petersburg

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