Erythema nodosum in Gianotti–Crosti syndrome associated with cytomegalovirus infection: a case report
- 作者: Pronskaya O.A.1,2, Bogomazov A.D.1, Bets O.G.1, Tynnikova V.V.1
-
隶属关系:
- Kursk State Medical University
- Zhiveli Paediatrics Centre
- 期: 卷 15, 编号 2 (2024)
- 页面: 93-100
- 栏目: Clinical observation
- URL: https://journals.eco-vector.com/pediatr/article/view/636254
- DOI: https://doi.org/10.17816/PED15293-100
- ID: 636254
如何引用文章
详细
Gianotti–Crosti syndrome and erythema nodosum can be triggered by many different infections. These conditions are rare, especially in combination with each other, and therefore require a competent approach to differential diagnosis and identification of the cause. This article describes a case of a rare combination of atypical nodular erythema and Gianotti–Crosti syndrome with cytomegalovirus infection. A 6-year-old patient was under outpatient treatment for acute respiratory viral infections and exanthema. The child had an aggravated family history of atopy. Acute cytomegalovirus infection was laboratory confirmed. The diagnosis was made: “Cytomegalovirus disease. Infantile papular acrodermatitis (Gianotti–Crosti syndrome)”. After 7 days, the symptoms of acrodermatitis resolved, but papular elements persisted and new hyperemic papular-vesicular rashes appeared. After 3 weeks, nodular erythema developed against the background of the existing elements. The clinical diagnosis was: “Erythema nodosum. Cytomegalovirus infection. Infantile papular acrodermatitis”. The diagnosis was confirmed after consultation with a rheumatologist. The prescribed treatment had no effect on the duration of the disease. Unusuality of erythema nodosum was manifested as absence of symptoms of acute respiratory viral infection, joint and muscle pain the day before. The patient was under paediatric care for 3.5 months, by the end of which the papular acrodermatitis and erythema nodosum resolved almost simultaneously. Paediatricians should consider the possibility of combining Gianotti–Crosti syndrome and erythema nodosum for timely diagnosis.
全文:
作者简介
Olga Pronskaya
Kursk State Medical University; Zhiveli Paediatrics Centre
Email: ms.fedina.olga@mail.ru
ORCID iD: 0009-0008-1733-9090
SPIN 代码: 5291-0430
Assistant Professor, Department of Pediatrics, Paediatrics Centre
俄罗斯联邦, 3 K. Marksa st., Kursk, 305041; KurskAlexey Bogomazov
Kursk State Medical University
Email: bogomazov71@mail.ru
ORCID iD: 0000-0002-4636-1819
SPIN 代码: 4932-4641
MD, PhD, Cand. Sci. (Medicine), Associate Professor, Department of Pediatrics
俄罗斯联邦, 3 K. Marksa st., Kursk, 305041, RussiaOlga Bets
Kursk State Medical University
Email: Bec_olga@rambler.ru
ORCID iD: 0000-0002-3435-0039
SPIN 代码: 2016-3260
Assistant Professor, Department of Pediatrics
俄罗斯联邦, 3 K. Marksa st., Kursk, 305041, RussiaValeria Tynnikova
Kursk State Medical University
编辑信件的主要联系方式.
Email: tynnikovavv@yandex.ru
ORCID iD: 0009-0002-0814-233X
SPIN 代码: 3607-0269
6th year student, Pediatrics Faculty
俄罗斯联邦, 3 K. Marksa st., Kursk, 305041, Russia参考
- Cohen BA. Pediatric dermatology. Moscow: MEDpress-Inform; 2021. 424 p. (In Russ.)
- Nenasheva NM, Chernyak BA, editors. Clinical allergology. Manual for practicing physicians. Moscow: GEOTAR-Media; 2022. 920 p. (In Russ.)
- Rodionov AN, Zaslavsky DV, Sydikov AA. Clinical dermatology. Illustrated guide for doctors. Rodionov AN, editor. Moscow: GEOTAR-Media; 2019. 712 p. (In Russ.)
- Russian Society of Dermatovenerologists and Cosmetologists, All-Russian Public Organization “Association of Rheumatologists of Russia”. Federal clinical recommendations for the management of patients with erythema nodosum. Moscow; 2016. (In Russ.)
- Ufimtseva MА, Nikolaeva KI, Sorokina KN, et al. Gianotti–Crosti syndrome. Clinical Practice in Pediatrics. 2019;14(1):41–45. EDN: NZZUJT doi: 10.20953/1817-7646-2019-1-41-45
- Aydın-Teke T, Tanir G, Bayhan GI, et al. Erythema nodosum in children: evaluation of 39 patients. Turk J Pediatr. 2014;56(2): 144–149.
- Chuh A, Zawar V, Lee A, Sciallis G. Is Gianotti–Crosti syndrome associated with atopy? A case-control study and a postulation on the intrinsic host factors in Gianotti–Crosti syndrome. Pediatr Dermatol. 2016;33(5):488–492. doi: 10.1111/pde.12886
- Laborada J, Cohen PR. Tuberculosis-associated erythema nodosum. Cureus. 2021;13(12):e20184. doi: 10.7759/cureus.20184
- Leung AKC, Sergi CM, Lam JM, Leong KF. Gianotti–Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition. World J Pediatr. 2019;15(6): 521–527. doi: 10.1007/s12519-019-00269-9
- Leung AKC, Leong KF, Lam JM. Erythema nodosum. World J Pediatr. 2018;14:548–554. doi: 10.1007/s12519-018-0191-1
- Molina-Ruiz AM, Requena L. Erythema nodosum. Medicina Clínica (English Edition). 2016;147(2):81–86. doi: 10.1016/j.medcli.2016.03.038
- Nazzaro G, Maronese CA, Passoni E. Ultrasonographic diagnosis of erythema nodosum. Skin Res Technol. 2022;28(2):361–364. doi: 10.1111/srt.13112
- Ozbagcivan O, Akarsu S, Avci C, et al. Examination of the microbial spectrum in the etiology of erythema nodosum: a retrospective descriptive study. J Immunol Res. 2017;2017:8139591. doi: 10.1155/2017/8139591
- Pérez-Garza DM, Chavez-Alvarez S, Ocampo-Candiani J, Gomez-Flores M. Erythema nodosum: a practical approach and diagnostic algorithm. J Clin Dermatol. 2021;22(3):367–378. doi: 10.1007/s40257-021-00592-w
- Spear JB, Kessler HA, Dworin A, Semel J. Erythema nodosum associated with acute cytomegalovirus mononucleosis in an adult. Arch Intern Med. 1988;148(2):323–324. doi: 10.1001/archinte.1988.00380010235026
- Tang H-C, Yen J-T, Kao C-C. Erythema nodosum associated with active cytomegalovirus infection. Chinese Journal of Dermatology. 2004;2(2):129–133.