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Сomparative analysis of acridineacetate-containing compounds’ radio-sensitizing effect during malignant tumor experimental radiotherapy in a metastatic colorectal cancer model in balb/c mice
- Authors: Trashkov A.P.1,2,3, Muzhikyan A.A.1,2, Tsygan N.V.1,2, Ryabtsev A.V.2, Rybakova A.V.1,2, Kvanchiani V.V.2, Kravtsova A.A.4, Vasiliev A.G.4
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Affiliations:
- National Research Centre “Kurchatov Institute”
- B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
- Peter the Great St. Petersburg Polytechnic University
- St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
- Issue: Vol 11, No 6 (2020)
- Pages: 45-53
- Section: Original studies
- URL: https://journals.eco-vector.com/pediatr/article/view/64890
- DOI: https://doi.org/10.17816/PED11645-53
- ID: 64890
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Abstract
Radio-sensitizing compounds are used to increase radiotherapy effectivity and reduce negative pathologic systemic effects of radiation. These radio-sensitizers selectively pile-up in tumor tissue and enhance necrobiotic processes caused by irradiation. Unfortunately, broad introduction of radio-sensitizers into clinical practice is hampered by their low effectivity and substantial negative side effects. This what determines radio-sensitizers effectivity studies high actuality in a colorectal cancer mice model. The study involved 156 male BALB/c mice who had been transplanted with colorectal cancer. After the transplantation they were injected with acridineacetate – containing compounds Cyclopherone and Procitol. A comparative assessment was undertaken of tumor growth dynamics and metastatic rate. A combination of gamma-irradiation with radio-sensitizing compounds produces a more substantial therapeutic effect according to all parameters of the experimental colorectal cancer growth and development than the isolated effect of radiotherapy or antitumor drugs. A considerable slowing down of tumor growth on the 14th and 28th day of the study was revealed as well as a reliable inhibition of lymphogenous and hematogenous metastatic spread of neoplasma during the entire study and a statistically valid increase of lifespan of the experimental animals. The radiosensitizing effect of Procitol in combination with radiotherapy turned out to be more substantial than that of Cyclopherone.
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About the authors
Alexander P. Trashkov
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Peter the Great St. Petersburg Polytechnic University
Author for correspondence.
Email: trashkov_ap@pnpi.nrcki.ru
PhD, MD, Head of Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Head of Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Assoc. Professor, St. Petersburg Polytechnical University
Russian Federation, Moscow; Saint Petersburg; Saint PetersburgArman A. Muzhikyan
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: vetdiagnostics.spb@gmail.com
PhD, Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Russian Federation, Moscow; Saint PetersburgNikolay V. Tsygan
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: tsygan_nv@pnpi.nrcki.ru
PhD, MD, Dr. Sci. (Med.), Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Russian Federation, Moscow; Saint PetersburgAlexander V. Ryabtsev
B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: ryabtsev26@gmail.com
Junior Researcher in Preclinincal and Clinical Studies Center
Russian Federation, Saint PetersburgAnna V. Rybakova
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: rybakova_av@pnpi.nrcki.ru
PhD, Senior Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Senior Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Russian Federation, Moscow; Saint PetersburgVarvara V. Kvanchiani
B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: kvanchiani_vv@pnpi.nrcki.ru
PhD, Senior Researcher in Preclinincal and Clinical Studies Center
Russian Federation, Saint PetersburgAleftina A. Kravtsova
St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
Email: aleftinakravcova@mail.ru
PhD, Associated Professor, Department Pathophysiology and Immunopathology
Russian Federation, Saint PetersburgAndrei G. Vasiliev
St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
Email: avas7@mail.ru
MD, PhD, Dr. Sci. (Med.), Head of Department Pathophysiology and Immunopathology
Russian Federation, Saint PetersburgReferences
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