Сomparative analysis of acridineacetate-containing compounds’ radio-sensitizing effect during malignant tumor experimental radiotherapy in a metastatic colorectal cancer model in balb/c mice

Cover Page

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Radio-sensitizing compounds are used to increase radiotherapy effectivity and reduce negative pathologic systemic effects of radiation. These radio-sensitizers selectively pile-up in tumor tissue and enhance necrobiotic processes caused by irradiation. Unfortunately, broad introduction of radio-sensitizers into clinical practice is hampered by their low effectivity and substantial negative side effects. This what determines radio-sensitizers effectivity studies high actuality in a colorectal cancer mice model. The study involved 156 male BALB/c mice who had been transplanted with colorectal cancer. After the transplantation they were injected with acridineacetate – containing compounds Cyclopherone and Procitol. A comparative assessment was undertaken of tumor growth dynamics and metastatic rate. A combination of gamma-irradiation with radio-sensitizing compounds produces a more substantial therapeutic effect according to all parameters of the experimental colorectal cancer growth and development than the isolated effect of radiotherapy or antitumor drugs. A considerable slowing down of tumor growth on the 14th and 28th day of the study was revealed as well as a reliable inhibition of lymphogenous and hematogenous metastatic spread of neoplasma during the entire study and a statistically valid increase of lifespan of the experimental animals. The radiosensitizing effect of Procitol in combination with radiotherapy turned out to be more substantial than that of Cyclopherone.

Full Text

Restricted Access

About the authors

Alexander P. Trashkov

National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Peter the Great St. Petersburg Polytechnic University

Author for correspondence.
Email: trashkov_ap@pnpi.nrcki.ru

PhD, MD, Head of Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Head of Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Assoc. Professor, St. Petersburg Polytechnical University

Russian Federation, Moscow; Saint Petersburg; Saint Petersburg

Arman A. Muzhikyan

National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Email: vetdiagnostics.spb@gmail.com

PhD, Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Russian Federation, Moscow; Saint Petersburg

Nikolay V. Tsygan

National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Email: tsygan_nv@pnpi.nrcki.ru

PhD, MD, Dr. Sci. (Med.), Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Russian Federation, Moscow; Saint Petersburg

Alexander V. Ryabtsev

B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Email: ryabtsev26@gmail.com

Junior Researcher in Preclinincal and Clinical Studies Center

Russian Federation, Saint Petersburg

Anna V. Rybakova

National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Email: rybakova_av@pnpi.nrcki.ru

PhD, Senior Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Senior Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Russian Federation, Moscow; Saint Petersburg

Varvara V. Kvanchiani

B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”

Email: kvanchiani_vv@pnpi.nrcki.ru

PhD, Senior Researcher in Preclinincal and Clinical Studies Center

Russian Federation, Saint Petersburg

Aleftina A. Kravtsova

St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: aleftinakravcova@mail.ru

PhD, Associated Professor, Department Pathophysiology and Immunopathology

Russian Federation, Saint Petersburg

Andrei G. Vasiliev

St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Email: avas7@mail.ru

MD, PhD, Dr. Sci. (Med.), Head of Department Pathophysiology and Immunopathology

Russian Federation, Saint Petersburg

References

  1. Бойко А.В., Дунаева Е.А., Демидова Л.В., и др. Профилактика и лечение ранних лучевых осложнений гидрогелевым материалом с деринатом у больных со злокачественными новообразованиями женских половых органов // Онкология. Журнал им. П.А. Герцена. – 2016. – Т. 5. – № 6. – С. 5–11. [Boyko AV, Dunaeva EA, Demidova LV, et al. Prevention and treatment of early radiation complications by the hydrogel material with derinat in patients with malignant neoplasms of the female genital organs. P.A. Herzen Journal of Oncology. 2016;5(6): 5-11. (In Russ.)] https://doi.org/10.17116/onkolog2016565-11.
  2. Жариков А.А., Терехов О.В. Онкологическая заболеваемость органов малого таза, лучевые повреждения и их диагностика (обзор литературы) // Радиация и риск. – 2013. – Т. 22. – № 3. – С. 57–64. [Zharikov AA, Terekhov OV. Pelvic cancer, radiation induced injury, diagnostics (review of literature). Radiacija i risk. 2013;22(3):57-64. (In Russ.)]
  3. Малиновская Е.А. Исследование эффективности гепатопротектора лохеина в комплексной терапии экспериментальных злокачественных опухолей // Сибирский онкологический журнал. – 2003. – № 4. – С. 17–21. [Malinovskaya EA. The study of the efficacy of lokhein hepatoprotector in the complex therapy of experimental malignant tumors. Siberian Journal of Oncology. 2003;(4):17–21. (In Russ.)]
  4. Островская Л.А., Корман Д.Б., Варфоломеев С.Д., и др. Полисукцинимид — противоопухолевая активность в эксперименте // Биофизика. – 2015. – Т. 60. – № 2. – С. 371–376. [Ostrovskaya LA, Korman DB, Varfolomeev SD, et al. Polysuccinimide: experimental antitumor activity. Biophysics. 2015;60(2):371-376. (In Russ.)]
  5. Cherdyntseva NV, Kokorev OV, Konovalova NP, Kagiya VT. Radiosensitizer AK-2123 enhances cytotoxic and cytostatic activity of splenocytes and macrophages in lewis lung carcinoma bearing mice treated with cyclophosphamide. Experimental Oncology. 1997;19(4): 333-337.
  6. Ягубов С.А., Аманджолов Б.С., Доненко Ф.В., и др. Влияние метронидазола на биологическое действие доксорубицина // Исследования и практика в медицине. – 2017. – Т. 4. – № 3. – С. 16–22. [Yagubov SA, Amandzholov BS, Donenko FV, et al. Influence of metronidazole on the biological action of doxorubicin. Research’n Practical Medicine Journal. 2017;4(3): 16-22. (In Russ.)] https://doi.org/10.17709/2409-2231-2017-4-3-2.
  7. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567-578. https://doi.org/10.1056/NEJMoa053422.
  8. Crentzberg C, Althol V, de Hoog M, et al. Quality control study of the accuracy of patient positioning in irradiation of pelvic fields. Int J Radiation Oncol Biol Phys. 1996;34(3):697-708. https://doi.org/10.1016/0360-3016(95)02034-9.

Statistics

Views

Abstract: 103

Dimensions

Article Metrics

Metrics Loading ...

PlumX


Copyright (c) 2020 Trashkov A.P., Muzhikyan A.A., Tsygan N.V., Ryabtsev A.V., Rybakova A.V., Kvanchiani V.V., Kravtsova A.A., Vasiliev A.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies