The effectiveness of different regimens of testosterone gel therapy in men with androgen deficiency

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Abstract

The results of androgen replacement therapy with the appointment of a transdermal gel with testosterone in patients with androgen deficiency were presented. 90 men with testosterone deficiency (<12 nmol/L) and impaired erectile function were observed. The average age of patients was 58 ± 5.2 years. Patients were divided into 3 groups. Patients of the 1st (control) group underwent basic behavioral therapy, the 2nd group received basic therapy with testosterone gel for a dose of 50 mg, the 3rd group received basic therapy with testosterone gel at a dose of 100 mg. The duration of treatment was 6 months. The use of testosterone in the form of a transdermal gel led to a significant increase in the content of total testosterone in both patients of the 2nd (50 mg) and 3rd groups (100 mg). A dose-dependent effect was noted, in patients of the 3rd group the level of testosterone was significantly higher than in patients 2nd group. An increase in testosterone was accompanied by a decrease in FSH and LH levels.

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About the authors

Andrey V. Kuzmenko

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: kuzmenkoav09@yandex.ru

Doctor of Medical Science, Professor, Head, Department of Urology

Russian Federation, Voronezh

Timur A. Gyaurgiev

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Email: tima001100@mail.ru

Candidate of Medical Science, Associate Professor, Department of Urology

Russian Federation, Voronezh

Yulia Yu. Bakutina

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Email: yul.bakutina@yandex.ru

Student

Russian Federation, Voronezh

Alena Yu. Zarubayco

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Email: alenazarubaiko@yandex.ru

Student

Russian Federation, Voronezh

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Copyright (c) 2020 Kuzmenko A.V., Gyaurgiev T.A., Bakutina Y.Y., Zarubayco A.Y.

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