The contribution of polymorphism in VDR gene FОKI in the development of osteopenia in pregnancy

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Abstract


The study involved 89 postpartum women and 97 nonpregnant women aged 20 to 35 years. The results of a genetic test compared with the BMD. In parturients in the lumbar spine the highest IPC and the value of the Z-scores were in patients with genotype FF, and the lowest with the genotype ff. Patients with the heterozygous genotype were charac terized by intermediate values of the BMD and Z-scores in the lumbar spine. A similar results was observed in the proximal femur and the distal forearm. The results of the correlation analysis showed a moderate negative correlation between the ff genotype and the level of BMD in lumbar spine (r = –0,44; p < 0.05) and proximal femur (r = –0.37; p < 0.05).


Olga S. Bibkova

Author for correspondence.
sudakkova@yandex.ru
I.P. Pavlov First St Petersburg State Medical University
Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

post-graduate student of Department of general practice

Dmitriy S. Sudakov

suddakovv@yandex.ru
North-Western State Medical University named after I.I. Mechnikov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

assistant professor of the Department of obstetrics and gynecology

Evdokia O. Bogdanova

evdokia.bogdanova@gmail.com
I.P. Pavlov First St Petersburg State Medical University
Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

researcher of the Laboratory of biochemical homeostasis Research institute of Nephrology

Natalia L. Shaporova

shapnl@mail.ru
I.P. Pavlov First St Petersburg State Medical University
Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

professor of the Department of general practice

Irina E. Zazerskaya

zazera@mail.ru
Federal Almazov North-West Medical Research Center
Russian Federation, 2 Akkuratova str., Saint- Petersburg, 197341

deputy director for research activities of Institute of perinatology and pediatrics

Olga V. Galkina

ovgalkina@mail.ru
I.P. Pavlov First St Petersburg State Medical University
Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

head of the Laboratory of biochemical homeostasis Research institute of Nephrology

Yulia R. Dymarskaya

julia_dym@mail.ru
North-Western State Medical University named after I.I. Mechnikov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

assistant professor of the Department of obstetrics and gynecology

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