Susceptibility of carbapenem-resistant strains of Klebsiella pneumoniae isolated from patients with severe trauma
- 作者: Meshkov A.V.1, Ilyina V.N.1, Demidovich G.I.1, Zhidik S.I.1, Datsuk A.O.1
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隶属关系:
- Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation
- 期: 卷 345, 编号 2 (2024)
- 页面: 53-59
- 栏目: Treatment and prophylactic issues
- URL: https://journals.eco-vector.com/0026-9050/article/view/627373
- DOI: https://doi.org/10.52424/00269050_2024_345_2_53
- ID: 627373
如何引用文章
详细
The article presents the results of a study aimed at identifying the mechanisms of resistance to antibiotics of the carbapenem group and determining active antimicrobials against carbapenem-resistant strains of Klebsiella pneumonia isolated from patients with severe trauma. 32 carbapenem-resistant strains of this microorganism were studied. Carbapenemases belonging to three molecular classes have been isolated. The article presents data on the frequency of detection of carbapenemase molecular classes A (groups KPC), D (groups OXA-48) and B (groups NDM), as well as the frequency of detection of strains with the presence of two genes simultaneously (groups OXA-48 and NDM) and spread of strains lacking known genes. Information is presented on the frequency of detection of carbapenemases belonging to different molecular classes depending on the source of isolation. The active antibiotic was determined against all tested strains. The results of the determination of sensitivity to antibiotics used in clinical practice are presented. Differences in the activity of antimicrobial drugs against producers of serine carbapenemases and metallo-β-lactamases were revealed. A comparison of our own results with data from other studies is given.
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作者简介
A. Meshkov
Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: vera_ilyina@rambler.ru
кандидат медицинских наук, полковник медицинской службы
俄罗斯联邦, Krasnogorsk, Moscow regionV. Ilyina
Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation
编辑信件的主要联系方式.
Email: vera_ilyina@rambler.ru
кандидат медицинских наук
俄罗斯联邦, Krasnogorsk, Moscow regionG. Demidovich
Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: vera_ilyina@rambler.ru
заслуженный работник здравоохранения РФ, полковник медицинской службы запаса
俄罗斯联邦, Krasnogorsk, Moscow regionS. Zhidik
Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: vera_ilyina@rambler.ru
полковник медицинской службы запаса
俄罗斯联邦, Krasnogorsk, Moscow regionA. Datsuk
Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: vera_ilyina@rambler.ru
подполковник медицинской службы
俄罗斯联邦, Krasnogorsk, Moscow region参考
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