Susceptibility of carbapenem-resistant strains of Klebsiella pneumoniae isolated from patients with severe trauma

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Abstract

The article presents the results of a study aimed at identifying the mechanisms of resistance to antibiotics of the carbapenem group and determining active antimicrobials against carbapenem-resistant strains of Klebsiella pneumonia isolated from patients with severe trauma. 32 carbapenem-resistant strains of this microorganism were studied. Carbapenemases belonging to three molecular classes have been isolated. The article presents data on the frequency of detection of carbapenemase molecular classes A (groups KPC), D (groups OXA-48) and B (groups NDM), as well as the frequency of detection of strains with the presence of two genes simultaneously (groups OXA-48 and NDM) and spread of strains lacking known genes. Information is presented on the frequency of detection of carbapenemases belonging to different molecular classes depending on the source of isolation. The active antibiotic was determined against all tested strains. The results of the determination of sensitivity to antibiotics used in clinical practice are presented. Differences in the activity of antimicrobial drugs against producers of serine carbapenemases and metallo-β-lactamases were revealed. A comparison of our own results with data from other studies is given.

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About the authors

A. V. Meshkov

Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: vera_ilyina@rambler.ru

кандидат медицинских наук, полковник медицинской службы

Russian Federation, Krasnogorsk, Moscow region

V. N. Ilyina

Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Author for correspondence.
Email: vera_ilyina@rambler.ru

кандидат медицинских наук 

Russian Federation, Krasnogorsk, Moscow region

G. I. Demidovich

Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: vera_ilyina@rambler.ru

заслуженный работник здравоохранения РФ, полковник медицинской службы запаса

Russian Federation, Krasnogorsk, Moscow region

S. I. Zhidik

Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: vera_ilyina@rambler.ru

полковник медицинской службы запаса

Russian Federation, Krasnogorsk, Moscow region

A. O. Datsuk

Branch No. 1 of the A.A.Vishnevsky National Medical Research Center for High Medical Technologies – Central Military Clinical Hospital of the Ministry of Defense of the Russian Federation

Email: vera_ilyina@rambler.ru

подполковник медицинской службы

Russian Federation, Krasnogorsk, Moscow region

References

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Supplementary files

Supplementary Files
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2. Fig.1. Distribution of the studied CRKP strains according to the source of their isolation (n=32)

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3. Рис. 2. Частота обнаружения карбапенемаз различных молекулярных классов (n=32)

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4. Fig. 3. Frequency of registration of enzymes of different molecular classes depending on the source of excretion (n=32), %

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Copyright (c) 2024 Meshkov A.V., Ilyina V.N., Demidovich G.I., Zhidik S.I., Datsuk A.O.


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