Vol 25, No 1 (2014)

The paper presents different variants of the onset and course of the primary biliary cirrhosis- autoimmune hepatitis overlap syndrome and discusses the problems encountered in the diagnosis and treatment of these liver injury forms characterized by a steady progression and unresponsiveness to performed immunosuppressive therapy.

Affective disorders are implicated in the pathogenesis of somatic diseases, such as hypertension, angina pectoris, myocardial infarction, asthma, etc., or aggravate their course. Thus, combination pharmacotherapy with drugs from different groups is used in patients with comorbidity. The CYP3A4 isoenzyme is known to metabolize about 70% of all known drugs. There are many CYP3A4 inhibitors among antidepressants. If a drug substrate is co-administered with a CYP3A4 inhibitor, the metabolism of the substrate slows down and it can be accumulated in the body; this increases the risk of adverse reactions. When comorbidities are treated, drugs should be prescribed with regard to metabolic pathways, which will make it possible to predict a priori undesirable interactions and to enhance the safety of performed combination therapy.

The use of phytoestrogens in women with menopausal syndrome developing in the presence of manifestations of chronic brain ischemia is a safe alternative to traditional hormone replacement therapy. The administration of Inoclim in women with cerebrovascular disease was assessed in an open-label placebo-controlled study.

Demographic, nosological, and pharmacotherapeutic characteristics required to predict a risk of drug interactions and to assess the rationality of combined pharmacotherapy in rheumatic patients have been obtained.

The high efficiency of monotherapy with Vagisept® as vaginal suppositories has been shown in the treatment of nonpregnant women with bacterial vaginosis and vaginitis, which permits the drug to be recommended for use in wide medical practice.

The paper describes the sequels of iron deficiency to a human being and presents the results of clinical studies evaluating the efficacy of iron (III) hydroxide polymaltose complex (Maltofer) used to prevent and treat the above deficiency in pregnant women, nursing mothers, and infants.

The authors assess the clinical and anamnestic characteristics of patients with infertility and peritoneal endometriosis versus NAT2 gene point mutations.

There is evidence that there is an inverse relationship between the level of dehydroepiandrosterone sulfate (DHEA-S) and the age of patients. At the same time, DHEA-S has been found to have an age-independent effect on erectile function. The latter is associated with the low serum level of DHEA-S.

A clinical example is given to show the development of acute psychosis in a patient with erysipelas of the leg. Biochemical interpretation substantiates the development of psychosis as a result of acute hypoproteinemia and hypoalbuminemia.

In Evenkia was demonstrated the prevalence of cholelithiasis in aliens inhabitants compared to Evenks. In both populations of patients with cholelithiasis were determined hyperlipidemia, increasing of deoxycholic and dehydrocholic acids content and decrease reducing of chenodeoxycholic acid concentration in bile. These changes were more pronounced in aliens in comparison with native population.

Important risk factors for insulin resistance (IR) in myocardial infarction (MI), along with insulinemia and glycemia, is to increase the concentration of free fatty acids (FFA) and the imbalance in the system adipokines against deficiency of ghrelin in acute and early recovery periods of the disease. FFA and ghrelin are promising laboratory markers for stratifying the risk of IR in patients with MI