卷 25, 编号 9 (2014)

The paper considers the safety of over-the-counter drugs used to treat influenza and other acute respiratory viral infections, which were the top 10 selling drugs in February-March 2014.

Cardiac fibrosis has recently generated great interest among clinicians and physiologists. Particular attention has been given to the role of fibrosis in the development of diastolic dysfunction and as a consequence in the occurrence of chronic heart failure with preserved ejection fraction. Myocardial biopsy with determination of the interstitial collagen volume fraction is considered to be the gold standard for qualitative and quantitative assessment of myocardial fibrosis. The histological signs of the latter are detectable just in the early stages of hypertension in patients with moderate left ventricular hypertrophy. However, lifetime endomyocardial biopsy is a traumatic diagnostic technique, thus the development of non-invasive readily accessible methods is of great importance. It is no less important to elaborate general criteria for the early diagnosis of diastolic heart failure, as well as methods for its treatment and prevention.

According to the 2000-2008 data, the causes of mortinatality in the Ivanovo Region were placental and umbilical cord abnormalities (70.8%) and fetal hypoxia (87.9%). Placental morphological changes in antenatal mortality were mainly associated with infection and its sequels and with impaired spiral artery remodeling in early pregnancy. A package of organizational measures for prevention of mortinatality has been defined.

The basic principles of multimodality therapy of pain syndrome in lumbosacral spine are discussed in this article. Represented algorithms, including psychoactive drug’ Selank application, have a great potential in a clinical practice of neurologist. A beneficial effect of Selank on the neuropathic component of radiculopathy was established in our study.

The paper presents special tools that can improve the technique of arthroscopic chondroplasty of the femoral condyles, by applying the Chondo-Guide collagen membrane. A hand cutting instrument to create the even margins of a cartilage defect and a ruler to measure its sizes are proposed. The use of the special cutting instrument could accelerate the preparation of the bone bed to implant the membrane by 2.9-fold and that of the ruler could determine the sizes of an implantable collagen membrane flap without employing a template, i.e. without resorting to arthrotomy.

Systemic ozone therapy used during combination treatment shows a significant reduction in the titer of soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1) in the peripheral plasma of patients with local cold injury and arterosclerosis obliterans of the lower extremities.

It has been found that the platelet coagulation hemostatic changes occurring at the onset of type 1 diabetes mellitus (DM1) are steady-state and unrelated to disease duration and their associated alterations in carbohydrate, protein, and lipid metabolic parameters are determined by the duration of DM1.

Long-term continuous ECG registration (for as long as 3 years) using implantable cardiac monitors can establish the cause of childhood syncope of unclear etiology in more than half of cases.

The results of treatment of ischemic heart disease in combination with arterial hypertension using routine methods and using Coronatera in the resort were compared. Preliminary studies have shown that the use of Coronatera during the course (18 days) leads to a decrease in systolic blood pressure on 7,15%, which is the best result. More powerful studies are needed to confirm the result and the formation of methodical recommendations on the application of Coronatera.

The paper presents data on life and labor potential losses due to deaths of the population of an industrial town and the results of practical measures aimed at reducing sociomedical losses.

The given system (using a neurological module as an example) provides support for treatment decision on the basis of guidelines and individual risk factors, generates protocols, and ensures a statistical analysis of data, automatic generation of a registry and an audit that includes quality indicators corrected for an individual risk profile.