Candida biofilm modeling: past and present


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Abstract

Mycoses are often associated with biofilms that are microbial communities encapsulated in a polysaccharide-rich extracellular matrix. Species of yeast-like fungi belonging to the genus Candida are the most common pathogens that cause superficial, deep, and systemic mycoses. Microorganisms that make up the biofilm have recently demonstrated decreased susceptibility to most therapeutic drugs, which contributes to the long-term persistence of infection. At the moment, there is a new branch of preventive and therapeutic medicine, which needs pharmaceuticals to be designed to prevent the formation of biofilms or the destruction of the already formed ones. Recent technological advances have contributed to the elaboration of new approaches to investigating the formation of biofilms and their models and to accumulating extensive knowledge about the influence of different variables on biofilm formation, morphology, and architectonics. There is information on current methods for modeling Candida biofilms and on their advantages or disadvantages in their structure and mechanisms.

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About the authors

Nadezda Pavlovna Sachivkina

Peoples' Friendship University of Russia

Email: sachivkina@yandex.ru
PhD in Biological Sciences, Associate Professor of Microbiology and Virology Department

Ekaterina Mikhailovna Lenchenko

Moscow state University of Food Production

Email: lenchenko.ekaterina@yandex.ru
Doctor of Veterinary Sciences,Professor of Veterinary Medicine Department

Ramziya Timergaleevna Mannapova

Russian State Agrarian University - The Moscow Agricultural Academy n.a. K.A. Timiryazev

Email: ram.mannapova55@mail.ru
Doctor of Biological Sciences,Professor of Microbiology and Immunology Department

AlexanderAnatolievich Anatol'evich Strizhakov

Peoples' Friendship University of Russia

Email: strizhakov-aa@rudn.ru
Doctor of Biological Sciences, Professor of Veterinary MedicineDepartment

Elena Valerievna Romanova

Peoples' Friendship University of Russia

Email: romanova-ev@rudn.ru
PhD inAgricultural Sciences, associate Professor of genetics, crop production and plant protection

Daria Mikhailovna Lukina

Peoples' Friendship University of Russia

Email: tell_tell@mail.ru
head of the Parasitologylaboratory of Veterinary Medicine Department

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