Design and standardization of the composition of suppositories containing antiviral components


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Abstract

Introduction. The antiviral drug Acyclovir is widely used in medical practice. The new antiviral drug Ryamilovir has recently appeared on the Russian pharmaceutical market. Objective: to design suppositories containing 2 antiviral drugs: Acyclovir and Ryamilovir. Methods. The investigation used the following methods: thin layer chromatography (TLC), spectrophotometry, semipermeable membrane dialysis, and statistical processing of the results. Results. The composition of bases and excipients was selected: it is recommended to use cocoa butter and aerosil as a suppository base under pharmacy conditions and polyethylene oxide and glyciram under production-line conditions. Components were identified using TLC and quantified by spectrophotometry, which allows one to determine both components in one sample. Conclusion. The composition of the suppositories containing 2 antiviral drugs Acyclovir and Ryamilovir was designed. A procedure was proposed to identify components using TLC and quantitative spectrophotometric determination.

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About the authors

Anna Yu. Saenko

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: anitakool@mail.ru
teacher of the Department of pharmacy FPO Pyatigorsk medical and pharmaceutical Institute-a branch of the VSTU MOH, candidate of pharmaceutical Sciences

Eleonora F. Stepanova

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: E.F.Stepanova@mail.ru
Professor of pharmaceutical technology and medical biotechnology Department

John S. Lazaryan

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: s.lazaryan@pmedpharm.ru
head of the Department of pharmaceutical and Toxicological chemistry

Alexander Yu. Petrov

Ural state medical University

Email: uniitmp@yandex.ru
Professor of the Department of pharmacy

Irina Ya. Kul

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: irinakool@mail.ru
senior lecturer of the Department of pharmaceutical and Toxicological chemistry

References

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