Licorice (Glycyrrhiza) roots: analysis of the requirements of the pharmacopoeia


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Abstract

Medicines derived from licorice (Glycyrrhiza) roots are used to treat various diseases worldwide. They have a beneficial effect on almost all human organs and systems. More than 1770 medicines based on licorice roots have been currently patented in the world; more than 30 drugs have been registered in the Russian Federation today. The chemical composition of licorice has been studied quite thoroughly; more than 400 compounds have been isolated from various species of licorice. Triterpene saponins and flavonoids are the most valuable biologically active substances for medicine and pharmaceutical industry. A large number of drugs, the production of which uses licorice roots, require that the regulatory documentation of up-to-date methods should be included in the standardization of the original pharmaceutical substance based on the plant licorice roots. The requirements for the quality of raw materials in the pharmacopoeias of various countries are analyzed; the way of improving Russian documentation is shown.

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About the authors

Valentina Alekseevna Ermakova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: ermakova1701@yandex.ru
professor Department of the Pharmaceutical Natural Science, Doctor Pharmaceutical Science Moscow, Russian Federation

Irina Aleksandrovna Samylina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: laznata@mail.ru
professor Department of the Pharmaceutical Natural Science, Doctor Pharmaceutical Science, Correspnding Member of the Russian Academy Sciences. Moscow, Russian Federation

Tatiana Yuryevna Kovaleva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: tatyana_kovaleva_75@inbox.ru
dotsent Department of the Pharmaceutical Natural Science, Candidat Pharmaceutical Science. Moscow, Russian Federation

Bogdan Viktorovich Brovchenko

OOO «AZTFarma K.B.»

Email: b.brovchenko@bk.ru
Deputy Director Moscow, Russian Federation

Ekaterina Anatolyevna Dorovskikh

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: 5ksusha5@mail.ru
postgraduate Student Department of the Pharmaceutical Natural Science Moscow, Russian Federation

Nataliya Vladimirovna Bobkova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: bobkovamma@mail.ru
professor Department of the Pharmaceutical Natural Science, Doctor Pharmaceutical Science. Moscow, Russian Federation

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