Pharmacoeconomic studies of novel antibacterial drugs active against multidrug resistant pathogens


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Abstract

The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacterbaumannii, Pseudomonas aeruginosa, and some Enterobacter species) are a group of the most dangerous multiple antibacterial resistant infectious agents. The choice of effective antibiotic therapy becomes a difficult task for limited state budgets, whereas the discovery of new molecules that can act on resistant pathogens is extremely difficult and requires a lot of resources and time. Therefore, the role of pharmacoeconomic analysis in the rational use of antibacterial drugs is growing significantly in our time. The results of pharmacoeconomic studies of innovative antibacterial drugs are an important tool for determining the feasibility of introducing these drugs into routine clinical practice. The analysis of relevant publications has revealed that the experience of pharmacoeconomic studies of using antibacterial drugs is limited and unreasonably rarely used for economic evaluation of the feasibility for administering novel antibacterial drugs. This study makes it possible to evaluate the experience with pharmacoeconomically analyzing the novel antibacterial drugs that are active against multidrug-resistant pathogens and to identify opportunities for further pharmacoeconomic studies of novel antibacterial drugs.

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About the authors

Dariya Dmitrievna Savintseva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: dariyasavintseva@gmail.com
postgraduate student of the Department of Clinical Pharmacology and Propaedeutics Moscow , Russian Federation

Igor Nikolaevich Sychev

Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation; Clinical Hospital named after S.S. Yudin

Email: sychevigor@mail.ru
Associate Professor of the Department of Clinical Pharmacology and Therapy of Russian Medical Academy of Continuing Professional Education, Head of the Clinical Pharmacology Department of Clinical Hospital named after S.S. Yudin, PhD of Medical Sciences Moscow , Russian Federation

Natalia Borisovna Lazareva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: natalia.lazareva@gmail.com
Professor, Department of Clinical Pharmacology and Propaedeutics Moscow , Russian Federation

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