Farnesol: properties, role, and prospects for use in the regulation of film formation in fungi of the genus Candida


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper describes the nature of farnesol, a secondary metabolite of isoprene substances, and its role as a QS-molecule in fungal intra- and interspecific chemocommunication. It discusses chemosignaling systems that regulate fundamental cellular processes, in which farnesol is involved. The authors analyze and systemize data on the use of farnesol in combination with antimycotic drugs against biofilms of yeast-like fungi of the genus Candida spp.

Full Text

Restricted Access

About the authors

Nadezda Pavlovna Sachivkina

Peoples' Friendship University of Russia

Email: sachivkina@yandex.ru
PhD in Biological Sciences, Associate Professor of Microbiology and Virology Department

Irina Viktorovna Podoprigora

Peoples' Friendship University of Russia

Email: podoprigora-iv@rudn.ru
PhD in Medical Sciences, head of the Microbiology and Virology Department

Anna Igorevna Marakhova

Peoples' Friendship University of Russia

Email: agentcat85@mail.ru
Grand PhD of Pharmaceutical Sciences, professor, Head of the Department of Scientific-educational centre «Nanotechnologies» IBCTN (SEC «Nanotechnologies»)

References

  1. Челпаченко О.Е., Перунова Н.Б., Иванова Е.В. и др. Микробиологические аспекты антимикотической фитотерапии. Проблемы медицинской микологии. 2014; 16 (3): 13-9. [Chelpachenko О.Е., Perunova N.B., Ivanova E.V. et al. Microbiological aspects of antimycotic herbal medicine. Problemy meditsinskoy mikologii. 2014; 16 (3): 13-9 (in Russian)]
  2. Pantira Singkum, Watcharamat Muangkaew, San Suwanmanee et al. Suppression of the pathogenicity of Candida albicans by the quorum-sensing molecules farnesol and tryptophol. J. Gen. Appl. Microbiol. 2019. https://doi.org/10.2323/jgam.2018.12.002
  3. Хайтович А.Б., Мурейко Е.А. Чувство кворума микроорганизмов как фактор патогенности. Таврический медико-биологический вестник. 2018; 21 (1): 206-12. [Khaytovich A.B., Mureyko Е.А. Sense of quorum of microorganisms as a factor of pathogenicity. Tavricheskiy mediko-biologicheskiy vestnik. 2018; 21 (1): 206-12 (in Russian)]
  4. Сачивкина Н.П., Ленченко Е.М., Маннапова Р.Т. и др. Моделирование биопленок Candida: прошлое и настоящее. Фармация. 2019; 68 (3): 18-22. https://doi.org/10/29296/25419218-2019-03-03 [SachivkinaN.P., Lenchenko Е.М., Mannapova R.T. et al. Modeling Candida Biofilms: Past and Present. Farmatsiya. 2019; 68 (3): 18-22. https://doi.org/10/29296/25419218-2019-03-03 (in Russian)]
  5. Сачивкина Н.П., Ленченко Е.М., Марахова А.И. Исследование формирования биопленок Candida albicans и Escherichia coli. Фармация. 2019; 68 (7): 26-30. https://doi. org/10/29296/25419218-2019-07-05 [SachivkinaN.P., Lenchenko Е.М., Marakhova A.I. Study of biofilm formation in Candida albicans and Escherichia coli. Farmatsiya. 2019; 68 (7): 26-30. https://doi. org/10/29296/25419218-2019-07-05 (in Russian)]
  6. Mosel D.D., Dumitru R., Hornby J.M. et al. Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. Appl. Environ. Microbiol. 2005; 71: 4938-40.
  7. Hornby J.M., Jensen E.C., Lisec A.D. et al. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl. Environ. Microbiol. 2001; 67: 2982-92.
  8. Chen H., Fujita M., Feng Q. et al. Tyrosol is a quorum-sensing molecule in Candida albicans. Proc. Natl. Acad. Sci. USA. 2004; 101: 5048-52.
  9. Lingappa B.T., Prasad M., Lingappa Y. et al. Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans. Science. 1969; 163: 192-4.
  10. Chen H., Fink G.R. Feedback control of morphogenesis in fungi by aromatic alcohols. Genes. Dev. 2006; 20: 1150-61.
  11. Савастеева А.В., Перунова Н.Б., Иванова Е.В., Челпаченко О.Е. Изучение влияния фарнезола на биопленкообразование Bifidobacterium spp. и Сandida spp. Успехи медицинской микологии. 2014; 12: 61-3. [Savasteeva A.V., Perunova N.B., Ivanova ЕХ, Chelpachenko О.Е. Study of the effect of farnesol on biofilm formation in Bifidobacterium spp. and Сandida spp. Uspekhi meditsinskoy mikologii. 2014; 12: 61-3 (in Russian)]
  12. Decanis N., Tazi N., Correia A. et al. Farnesol, a fungal quorum-sensing molecule triggers Candida albicans morphological changes by downregulating the expression of different secreted aspartyl proteinase genes. Open Microbiol. J. 2011; 5: 119-26.
  13. Weber K., Schulz B., Ruhnke M. The quorum-sensing molecule E, E-farnesol - its variable secretion and its impact on the growth and metabolism of Candida species. Yeast. 2010; 27: 727-39.
  14. Langford M.L., Hasim S., Nickerson K.W. et al. Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. Antimicrob. Agents Chemother. 2010; 54: 940-2.
  15. Hisajima T., Maruyama N., Tanabe Y. et al. Protective effects of farnesol against oral candidiasis in mice. Microbiol. Immunol. 2008; 52: 327-33.
  16. Navarathna D.H., Nickerson K.W., Duhamel G.E. et al. Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. Infect. Immun. 2007; 75: 4006-11.
  17. Abe S., Tsunashima R., Iijima R. et al. Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. Microbiol. Immunol. 2009; 53: 323-30.
  18. Hargarten J.C., Moore T.C., Petro T.M. et al. Candida, albicans quorum sensing molecules stimulate mouse macrophage migration. Infect. Immun. 2015; 83: 3857-64.
  19. Тапильская Н.И., Гайдуков С.Н. Механизмы формирования резистентности к терапии кандидозного вульвовагинита: пути преодоления и профилактика рецидива. Лечащий врач. 2016; 6: 71-7 [Tapil'skaya N.I., Gaydurov S.N. Mechanisms of the formation of resistance to therapy of vulvovaginal candidiasis: ways to overcome and prevent relapse. Lechashchiy vrach. 2016; 6: 71-7 (in Russian)]
  20. Hornby J.M., Nickerson K.W. Enhanced production of farnesol by Candida albicans treated with four azoles. Antimicrob. Agents Chemother. 2004; 48: 2305-7.
  21. Jabra-Rizk M.A., Shirtliff M., James C. et al. Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. FEMS Yeast Res. 2006; 6: 1063-73.
  22. Katragkou A., McCarthy M., Alexander E.L.et al. In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms. J. Antimicrob. Chemother. 2015; 70: 470-8. https://doi.org/10.1093/jac/dku374
  23. Fernandez-Rivero M. E., Jose L., Amparo V. et al. Activity of Amphotericin B and Anidulafungin Combined with Rifampicin, Clarithromycin, Ethylenediaminetetraacetic Acid, N-Acetylcysteine, and Farnesol against Candida tropicalis Biofilms. J. Fungi. 2017; 3: 16. https://doi.org/10.3390/jof3010016
  24. Cordeiro R.A., Teixeira C.E., Brilhante R.S. et al. Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. Med. Mycol. 2013; 51: 53-9.
  25. Sachivkina N., Lenchenko E., Blumenkrants D. et al. Effects of farnesol and lyticase on the formation of Candida albicans biofilm. Veterinary World. 2020; 13 (6): 1030-6.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies