Development of technology and procedures for analysis of rectal suppositories with phytoconstituents


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Abstract

Introduction. In recent years, suppositories have become increasingly important in medical practice. A special place is occupied by suppositories used in pediatric and geriatric practice, as well as in the long-term treatment of chronic diseases. In these cases, suppositories containing biologically active substances (BAS) of plant origin are of particular importance. Objective: to develop technology for suppositories with the phytoconstituents: rotocan and alcohol extract from bay laurel (Laurus nobilis) leaves. Material and methods. The investigation used aminocaproic acid, rotocan, bay laurel leaves, as well as techniques, such as spectrophotometry, alkalimetry, thin-layer chromatography, statistical processing of experimental results. Results. A technology was developed to prepare alcoholic extract from the leaves of bay laurel and its based suppositories. A technology was proposed to manufacture suppositories containing aminocaproic acid and rotocan. Conclusion. A technology was developed to prepare suppositories with alcohol extract from bay laurel leaves, as well as those with rotocan and aminocaproic acid. Procedures were proposed for their analysis. The designed medicines were standardized; their shelf-lives were established.

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About the authors

Anna Yur'evna Saenko

Pyatigorsk Medical Pharmaceutical Institute Branch Volgograd State Medical University

Email: anitakool@mail.ru
Teacher of the Department of Pharmacy of the Pyatigorsk medical and pharmaceutical Institute 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation

Eleonora Fedorovna Stepanova

Pyatigorsk Medical Pharmaceutical Institute Branch Volgograd State Medical University

Email: s.lazaryan@pmedpharm.ru
Professor of the Department of Pharmaceutical Technology and Medical Biotechnology of the PyatMPhI, Doctor of Pharmaceutical Sciences, Professor. 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation

John Sedrakovich Lazaryan

Pyatigorsk Medical Pharmaceutical Institute Branch Volgograd State Medical University

Email: s.lazaryan@pmedpharm.ru
Head of the Department of Pharmaceutical and Toxicological Chemistry, Doctor of Pharmaceutical Sciences, Professor. 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation

Alexander Yur'evich Petrov

Ural State Medical Academy

Professor of the Department of Pharmacy; Doctor of Pharmaceutical Sciences, Professor. 3, Repin St., Yekaterinburg 620028, Russian Federation

Irina Yakovlevna Kul

Pyatigorsk Medical Pharmaceutical Institute Branch Volgograd State Medical University

Email: irinakool@mail.ru
teacher lecturer of the Department of Pharmaceutical and Toxicological Chemistry of the PyatMPhI, PhD 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation

Oleg Nikolaevich Denisenko

Pyatigorsk Medical Pharmaceutical Institute Branch Volgograd State Medical University

Email: don1945@yandex.ru
Head of the Department of Pharmacy, Doctor of Pharmaceutical Sciences, Professor. 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation

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